High-Throughput Screen for Inhibitors of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase by Surrogate Ligand Competition

1-Deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) is a key enzyme in a biosynthetic pathway for isoprenoids that is unique to eubacteria and plants. Dxr catalyzes the rearrangement and NADPH-dependent reduction of 1-deoxy-D-xylulose 5-phosphate to 2-C-methyl-D-erythritol 4-phosphate. The authors...

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Veröffentlicht in:	Journal of biomolecular screening 2003-06, Vol.8 (3), p.332-339
Hauptverfasser:	Gottlin, Elizabeth B., Benson, R. Edward, Conary, Scott, Antonio, Brett, Duke, Kellie, Payne, E. Sturgis, Ashraf, S. Salman, Christensen, Dale J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldose-Ketose Isomerases - antagonists & inhibitors Binding Sites Binding, Competitive Dose-Response Relationship, Drug Drug Design Drug Industry Enzyme Inhibitors - pharmacology Escherichia coli Escherichia coli - enzymology Eubacteria Europium - chemistry Fosfomycin - analogs & derivatives Fosfomycin - pharmacology Inhibitory Concentration 50 Ligands Models, Chemical Multienzyme Complexes - antagonists & inhibitors NADP - chemistry Oxidoreductases - antagonists & inhibitors Peptide Library Peptides - chemistry Spectrometry, Fluorescence Streptavidin - chemistry Time Factors
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