A Versatile High-Throughput Screen for Inhibitors of Lipid Kinase Activity: Development of an Immobilized Phospholipid Plate Assay for Phosphoinositide 3-Kinase γ

The family of phosphoinositide 3-kinases (PI3K) regulates fundamental cellular responses such as proliferation, apoptosis, motility, and adhesion. In particular, the PI3K γ isoform plays a critical role in the control of cell migration. Despite the attractiveness of PI3-kinases as drug targets, drug...

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Veröffentlicht in:	Journal of biomolecular screening 2002-10, Vol.7 (5), p.441-450
Hauptverfasser:	Fuchikami, Kinji, Togame, Hiroko, Sagara, Atsuko, Satoh, Tomoko, Gantner, Florian, Bacon, Kevin B., Reinemer, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Androstadienes - pharmacology Biological Assay - instrumentation Biological Assay - methods Class Ib Phosphatidylinositol 3-Kinase Drug Evaluation, Preclinical - methods Enzyme Inhibitors - pharmacology Humans Isoenzymes - antagonists & inhibitors Isoenzymes - genetics Isoenzymes - metabolism Lipid Metabolism Microchemistry - instrumentation Microchemistry - methods Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositols - metabolism Phospholipids - chemistry Phospholipids - metabolism Phosphorus Radioisotopes - chemistry Quercetin - pharmacology Recombinant Proteins - genetics Recombinant Proteins - metabolism Staurosporine - pharmacology
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