Therapeutic Effect and Mechanism of Glabridin Liposome on Imiquimod-induced Mice Psoriasis
Background Glabridin is one of the main components of the isoflavonoids in Glycyrrhiza glabra and possesses anti-inflammatory, anti-bacterial, and anti-cancer effects. Objectives Herein, the therapeutic effects and mechanisms of action of the glabridin liposome (GL) complex were studied in mice with...
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| Veröffentlicht in: | Pharmacognosy Magazine 2024-03, Vol.20 (1), p.72-80 |
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| creator | Lu, Yongjie Cheng, Lushi Ren, Lu Chen, Dongqiu Guan, Shumin Zhu, Siyang Xu, Xian Zhang, Bing Tang, Minghui Zhang, Chijian Ai, Yong Zhang, Lanyue He, Tinggang |
| description | Background
Glabridin is one of the main components of the isoflavonoids in Glycyrrhiza glabra and possesses anti-inflammatory, anti-bacterial, and anti-cancer effects.
Objectives
Herein, the therapeutic effects and mechanisms of action of the glabridin liposome (GL) complex were studied in mice with imiquimod-induced psoriasis.
Materials and Methods
After treatment with GLs, their effectiveness was assessed using parameters, such as Psoriasis Area and Severity Index (PASI) score, histopathology, inflammatory cytokines, and psoriasis-associated proteins.
Results
The results demonstrated that GLs could significantly improve psoriatic symptoms, downregulate mast cell infiltration, and significantly reduce the PASI score of psoriatic mice. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) results showed that GLs significantly decreased IL-23 and STAT3 mRNA expression. The results of immunohistochemistry and the enzyme-linked immunosorbent assay indicated that GLs decreased the expression of tumor necrosis factor-alpha (TNF-α), IL-17, and IL-22.
Conclusion
GLs can alleviate psoriasis by inhibiting the expression of keratinocyte-activating proteins. These results suggest that GLs have great potential for the clinical treatment of psoriasis. |
| doi_str_mv | 10.1177/09731296231198931 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_09731296231198931</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_09731296231198931</sage_id><sourcerecordid>10.1177_09731296231198931</sourcerecordid><originalsourceid>FETCH-LOGICAL-c257t-8fb6a7bc1556a67fcf83f98ff184cef17be2dd45b8239d8f0bdd7f61fd3ad4b23</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EEqXwAez8AykeO4mdJapKQSqCRdmwifwa6qqJi90s-HtSyg6J1VyN7hmNDiG3wGYAUt6xRgrgTc0FQKMaAWdkMu7qomQ1P__JojgWLslVzlvGKgVMTsj7euOT3vvhECxdIHp7oLp39Nnbje5D7mhEutxpk4ILPV2Ffcyx8zT29KkLn0PooitC7wbrRyhYT19zTEHnkK_JBepd9je_c0reHhbr-WOxelk-ze9XheWVPBQKTa2lsVBVta4lWlQCG4UIqrQeQRrPnSsro7honEJmnJNYAzqhXWm4mBI43bUp5pw8tvsUOp2-WmDtUU77R87IzE5M1h--3cYh9eOL_wDf_wVmOw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Therapeutic Effect and Mechanism of Glabridin Liposome on Imiquimod-induced Mice Psoriasis</title><source>Sage Journals GOLD Open Access 2024</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Lu, Yongjie ; Cheng, Lushi ; Ren, Lu ; Chen, Dongqiu ; Guan, Shumin ; Zhu, Siyang ; Xu, Xian ; Zhang, Bing ; Tang, Minghui ; Zhang, Chijian ; Ai, Yong ; Zhang, Lanyue ; He, Tinggang</creator><creatorcontrib>Lu, Yongjie ; Cheng, Lushi ; Ren, Lu ; Chen, Dongqiu ; Guan, Shumin ; Zhu, Siyang ; Xu, Xian ; Zhang, Bing ; Tang, Minghui ; Zhang, Chijian ; Ai, Yong ; Zhang, Lanyue ; He, Tinggang</creatorcontrib><description>Background
Glabridin is one of the main components of the isoflavonoids in Glycyrrhiza glabra and possesses anti-inflammatory, anti-bacterial, and anti-cancer effects.
Objectives
Herein, the therapeutic effects and mechanisms of action of the glabridin liposome (GL) complex were studied in mice with imiquimod-induced psoriasis.
Materials and Methods
After treatment with GLs, their effectiveness was assessed using parameters, such as Psoriasis Area and Severity Index (PASI) score, histopathology, inflammatory cytokines, and psoriasis-associated proteins.
Results
The results demonstrated that GLs could significantly improve psoriatic symptoms, downregulate mast cell infiltration, and significantly reduce the PASI score of psoriatic mice. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) results showed that GLs significantly decreased IL-23 and STAT3 mRNA expression. The results of immunohistochemistry and the enzyme-linked immunosorbent assay indicated that GLs decreased the expression of tumor necrosis factor-alpha (TNF-α), IL-17, and IL-22.
Conclusion
GLs can alleviate psoriasis by inhibiting the expression of keratinocyte-activating proteins. These results suggest that GLs have great potential for the clinical treatment of psoriasis.</description><identifier>ISSN: 0973-1296</identifier><identifier>EISSN: 0976-4062</identifier><identifier>DOI: 10.1177/09731296231198931</identifier><language>eng</language><publisher>New Delhi, India: SAGE Publications</publisher><ispartof>Pharmacognosy Magazine, 2024-03, Vol.20 (1), p.72-80</ispartof><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c257t-8fb6a7bc1556a67fcf83f98ff184cef17be2dd45b8239d8f0bdd7f61fd3ad4b23</citedby><cites>FETCH-LOGICAL-c257t-8fb6a7bc1556a67fcf83f98ff184cef17be2dd45b8239d8f0bdd7f61fd3ad4b23</cites><orcidid>0000-0002-5153-5473</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/09731296231198931$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/09731296231198931$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,21946,27832,27903,27904,44924,45312</link.rule.ids></links><search><creatorcontrib>Lu, Yongjie</creatorcontrib><creatorcontrib>Cheng, Lushi</creatorcontrib><creatorcontrib>Ren, Lu</creatorcontrib><creatorcontrib>Chen, Dongqiu</creatorcontrib><creatorcontrib>Guan, Shumin</creatorcontrib><creatorcontrib>Zhu, Siyang</creatorcontrib><creatorcontrib>Xu, Xian</creatorcontrib><creatorcontrib>Zhang, Bing</creatorcontrib><creatorcontrib>Tang, Minghui</creatorcontrib><creatorcontrib>Zhang, Chijian</creatorcontrib><creatorcontrib>Ai, Yong</creatorcontrib><creatorcontrib>Zhang, Lanyue</creatorcontrib><creatorcontrib>He, Tinggang</creatorcontrib><title>Therapeutic Effect and Mechanism of Glabridin Liposome on Imiquimod-induced Mice Psoriasis</title><title>Pharmacognosy Magazine</title><description>Background
Glabridin is one of the main components of the isoflavonoids in Glycyrrhiza glabra and possesses anti-inflammatory, anti-bacterial, and anti-cancer effects.
Objectives
Herein, the therapeutic effects and mechanisms of action of the glabridin liposome (GL) complex were studied in mice with imiquimod-induced psoriasis.
Materials and Methods
After treatment with GLs, their effectiveness was assessed using parameters, such as Psoriasis Area and Severity Index (PASI) score, histopathology, inflammatory cytokines, and psoriasis-associated proteins.
Results
The results demonstrated that GLs could significantly improve psoriatic symptoms, downregulate mast cell infiltration, and significantly reduce the PASI score of psoriatic mice. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) results showed that GLs significantly decreased IL-23 and STAT3 mRNA expression. The results of immunohistochemistry and the enzyme-linked immunosorbent assay indicated that GLs decreased the expression of tumor necrosis factor-alpha (TNF-α), IL-17, and IL-22.
Conclusion
GLs can alleviate psoriasis by inhibiting the expression of keratinocyte-activating proteins. These results suggest that GLs have great potential for the clinical treatment of psoriasis.</description><issn>0973-1296</issn><issn>0976-4062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><recordid>eNp9kMtOwzAQRS0EEqXwAez8AykeO4mdJapKQSqCRdmwifwa6qqJi90s-HtSyg6J1VyN7hmNDiG3wGYAUt6xRgrgTc0FQKMaAWdkMu7qomQ1P__JojgWLslVzlvGKgVMTsj7euOT3vvhECxdIHp7oLp39Nnbje5D7mhEutxpk4ILPV2Ffcyx8zT29KkLn0PooitC7wbrRyhYT19zTEHnkK_JBepd9je_c0reHhbr-WOxelk-ze9XheWVPBQKTa2lsVBVta4lWlQCG4UIqrQeQRrPnSsro7honEJmnJNYAzqhXWm4mBI43bUp5pw8tvsUOp2-WmDtUU77R87IzE5M1h--3cYh9eOL_wDf_wVmOw</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Lu, Yongjie</creator><creator>Cheng, Lushi</creator><creator>Ren, Lu</creator><creator>Chen, Dongqiu</creator><creator>Guan, Shumin</creator><creator>Zhu, Siyang</creator><creator>Xu, Xian</creator><creator>Zhang, Bing</creator><creator>Tang, Minghui</creator><creator>Zhang, Chijian</creator><creator>Ai, Yong</creator><creator>Zhang, Lanyue</creator><creator>He, Tinggang</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-5153-5473</orcidid></search><sort><creationdate>202403</creationdate><title>Therapeutic Effect and Mechanism of Glabridin Liposome on Imiquimod-induced Mice Psoriasis</title><author>Lu, Yongjie ; Cheng, Lushi ; Ren, Lu ; Chen, Dongqiu ; Guan, Shumin ; Zhu, Siyang ; Xu, Xian ; Zhang, Bing ; Tang, Minghui ; Zhang, Chijian ; Ai, Yong ; Zhang, Lanyue ; He, Tinggang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c257t-8fb6a7bc1556a67fcf83f98ff184cef17be2dd45b8239d8f0bdd7f61fd3ad4b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Yongjie</creatorcontrib><creatorcontrib>Cheng, Lushi</creatorcontrib><creatorcontrib>Ren, Lu</creatorcontrib><creatorcontrib>Chen, Dongqiu</creatorcontrib><creatorcontrib>Guan, Shumin</creatorcontrib><creatorcontrib>Zhu, Siyang</creatorcontrib><creatorcontrib>Xu, Xian</creatorcontrib><creatorcontrib>Zhang, Bing</creatorcontrib><creatorcontrib>Tang, Minghui</creatorcontrib><creatorcontrib>Zhang, Chijian</creatorcontrib><creatorcontrib>Ai, Yong</creatorcontrib><creatorcontrib>Zhang, Lanyue</creatorcontrib><creatorcontrib>He, Tinggang</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>CrossRef</collection><jtitle>Pharmacognosy Magazine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Yongjie</au><au>Cheng, Lushi</au><au>Ren, Lu</au><au>Chen, Dongqiu</au><au>Guan, Shumin</au><au>Zhu, Siyang</au><au>Xu, Xian</au><au>Zhang, Bing</au><au>Tang, Minghui</au><au>Zhang, Chijian</au><au>Ai, Yong</au><au>Zhang, Lanyue</au><au>He, Tinggang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic Effect and Mechanism of Glabridin Liposome on Imiquimod-induced Mice Psoriasis</atitle><jtitle>Pharmacognosy Magazine</jtitle><date>2024-03</date><risdate>2024</risdate><volume>20</volume><issue>1</issue><spage>72</spage><epage>80</epage><pages>72-80</pages><issn>0973-1296</issn><eissn>0976-4062</eissn><abstract>Background
Glabridin is one of the main components of the isoflavonoids in Glycyrrhiza glabra and possesses anti-inflammatory, anti-bacterial, and anti-cancer effects.
Objectives
Herein, the therapeutic effects and mechanisms of action of the glabridin liposome (GL) complex were studied in mice with imiquimod-induced psoriasis.
Materials and Methods
After treatment with GLs, their effectiveness was assessed using parameters, such as Psoriasis Area and Severity Index (PASI) score, histopathology, inflammatory cytokines, and psoriasis-associated proteins.
Results
The results demonstrated that GLs could significantly improve psoriatic symptoms, downregulate mast cell infiltration, and significantly reduce the PASI score of psoriatic mice. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) results showed that GLs significantly decreased IL-23 and STAT3 mRNA expression. The results of immunohistochemistry and the enzyme-linked immunosorbent assay indicated that GLs decreased the expression of tumor necrosis factor-alpha (TNF-α), IL-17, and IL-22.
Conclusion
GLs can alleviate psoriasis by inhibiting the expression of keratinocyte-activating proteins. These results suggest that GLs have great potential for the clinical treatment of psoriasis.</abstract><cop>New Delhi, India</cop><pub>SAGE Publications</pub><doi>10.1177/09731296231198931</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5153-5473</orcidid><oa>free_for_read</oa></addata></record> |
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| title | Therapeutic Effect and Mechanism of Glabridin Liposome on Imiquimod-induced Mice Psoriasis |
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