Non-neoplastic findings at colonoscopy after positive faecal occult blood testing: Data from the English Bowel Cancer Screening Programme
Background The aim of the English Bowel Cancer Screening Programme (BCSP) is to diagnose early colorectal cancer and advanced adenomas. However, other findings are also reported at screening colonoscopy. Small studies demonstrate findings other than cancer or adenomas (non-neoplastic findings (NNF))...
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| Veröffentlicht in: | Journal of medical screening 2014-06, Vol.21 (2), p.89-94 |
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| creator | Bevan, Roisin Lee, Thomas JW Nickerson, Claire Rubin, Greg Rees, Colin J |
| description | Background
The aim of the English Bowel Cancer Screening Programme (BCSP) is to diagnose early colorectal cancer and advanced adenomas. However, other findings are also reported at screening colonoscopy. Small studies demonstrate findings other than cancer or adenomas (non-neoplastic findings (NNF)) in 11–25%.
Objectives and setting
Describe the frequency and nature of NNF within the BSCP.
Methods
Data were obtained from the BCSP national database for all individuals undergoing colonoscopic investigation after positive faecal occult blood testing between August 2006 and November 2011. Data included demographics, smoking status, neoplastic findings and NNF.
Results
121728 colonoscopies were analysed. ≥1 NNF were found in 26251 cases (21.6%). Diverticular disease (18875 cases) and haemorrhoids (7011) were the most frequently reported. Inflammatory bowel disease (IBD) was reported in 2152 cases. Individuals with a neoplastic diagnosis were less likely to have an NNF than those without (19.8% v 24.4%, p |
| doi_str_mv | 10.1177/0969141314528889 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_0969141314528889</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0969141314528889</sage_id><sourcerecordid>10.1177_0969141314528889</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-8bb258676a2a8527e291a83ee4df79f865ecaa1f6730806e28aad7e9a7378f913</originalsourceid><addsrcrecordid>eNp1kM1u2zAQhImiQew4vfdU8AWUkKIkkr21rvMDGGmApGdhTS1lGRIpkHSKPELeujKc5hAgpz3MzIfZIeQrZxecS3nJdKV5wQUvylwppT-ROS9kmZVSi89kfpCzgz4jZzHuGGOCc3VKZnlRFQXL9Zy83HmXOfRjDzF1htrONZ1rI4VEje-989H48ZmCTRjo6GOXuiekFtBAT70x-z7RTe99QxNOBNd-p78gAbXBDzRtka5c23dxS3_6v9jTJTgzgR5MQHSTm94H3wYYBjwnJxb6iF9e74L8uVo9Lm-y9e_r2-WPdWaEkClTm01eqkpWkIMqc4m55qAEYtFYqa2qyqkZcFtJwRSrMFcAjUQNUkhlNRcLwo5cE3yMAW09hm6A8FxzVh9Wrd-vOkW-HSPjfjNg8xb4P-NkyI6GCC3WO78PbnrhY-A_q6SBng</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Non-neoplastic findings at colonoscopy after positive faecal occult blood testing: Data from the English Bowel Cancer Screening Programme</title><source>Access via SAGE</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Bevan, Roisin ; Lee, Thomas JW ; Nickerson, Claire ; Rubin, Greg ; Rees, Colin J</creator><creatorcontrib>Bevan, Roisin ; Lee, Thomas JW ; Nickerson, Claire ; Rubin, Greg ; Rees, Colin J ; NHS BCSP Evaluation Group</creatorcontrib><description>Background
The aim of the English Bowel Cancer Screening Programme (BCSP) is to diagnose early colorectal cancer and advanced adenomas. However, other findings are also reported at screening colonoscopy. Small studies demonstrate findings other than cancer or adenomas (non-neoplastic findings (NNF)) in 11–25%.
Objectives and setting
Describe the frequency and nature of NNF within the BSCP.
Methods
Data were obtained from the BCSP national database for all individuals undergoing colonoscopic investigation after positive faecal occult blood testing between August 2006 and November 2011. Data included demographics, smoking status, neoplastic findings and NNF.
Results
121728 colonoscopies were analysed. ≥1 NNF were found in 26251 cases (21.6%). Diverticular disease (18875 cases) and haemorrhoids (7011) were the most frequently reported. Inflammatory bowel disease (IBD) was reported in 2152 cases. Individuals with a neoplastic diagnosis were less likely to have an NNF than those without (19.8% v 24.4%, p < 0.001). After adjustment for confounding using multivariable analysis, older age was still associated with a small but statistically significant risk of NNF.
Conclusions
The BCSP generates a significant volume of NNF. A small proportion of individuals were found to have inflammatory bowel disease (IBD) - an important diagnosis with implications for long-term management. BCSP participants should be aware that findings other than neoplasia may be detected and the relevance of these findings to that individual is not known. Reporting of NNF varies between colonoscopists, and potential underreporting is a limitation of this study. Further study is required to establish the impact of NNF on primary and secondary care.</description><identifier>ISSN: 0969-1413</identifier><identifier>EISSN: 1475-5793</identifier><identifier>DOI: 10.1177/0969141314528889</identifier><identifier>PMID: 24644029</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Colonoscopy - statistics & numerical data ; Colorectal Neoplasms - diagnosis ; Early Detection of Cancer ; Female ; Guaiac ; Humans ; Inflammatory Bowel Diseases - diagnosis ; Male ; Mass Screening ; Middle Aged ; Occult Blood ; Predictive Value of Tests ; Reagent Kits, Diagnostic - standards</subject><ispartof>Journal of medical screening, 2014-06, Vol.21 (2), p.89-94</ispartof><rights>The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><rights>The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-8bb258676a2a8527e291a83ee4df79f865ecaa1f6730806e28aad7e9a7378f913</citedby><cites>FETCH-LOGICAL-c337t-8bb258676a2a8527e291a83ee4df79f865ecaa1f6730806e28aad7e9a7378f913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0969141314528889$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0969141314528889$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24644029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bevan, Roisin</creatorcontrib><creatorcontrib>Lee, Thomas JW</creatorcontrib><creatorcontrib>Nickerson, Claire</creatorcontrib><creatorcontrib>Rubin, Greg</creatorcontrib><creatorcontrib>Rees, Colin J</creatorcontrib><creatorcontrib>NHS BCSP Evaluation Group</creatorcontrib><title>Non-neoplastic findings at colonoscopy after positive faecal occult blood testing: Data from the English Bowel Cancer Screening Programme</title><title>Journal of medical screening</title><addtitle>J Med Screen</addtitle><description>Background
The aim of the English Bowel Cancer Screening Programme (BCSP) is to diagnose early colorectal cancer and advanced adenomas. However, other findings are also reported at screening colonoscopy. Small studies demonstrate findings other than cancer or adenomas (non-neoplastic findings (NNF)) in 11–25%.
Objectives and setting
Describe the frequency and nature of NNF within the BSCP.
Methods
Data were obtained from the BCSP national database for all individuals undergoing colonoscopic investigation after positive faecal occult blood testing between August 2006 and November 2011. Data included demographics, smoking status, neoplastic findings and NNF.
Results
121728 colonoscopies were analysed. ≥1 NNF were found in 26251 cases (21.6%). Diverticular disease (18875 cases) and haemorrhoids (7011) were the most frequently reported. Inflammatory bowel disease (IBD) was reported in 2152 cases. Individuals with a neoplastic diagnosis were less likely to have an NNF than those without (19.8% v 24.4%, p < 0.001). After adjustment for confounding using multivariable analysis, older age was still associated with a small but statistically significant risk of NNF.
Conclusions
The BCSP generates a significant volume of NNF. A small proportion of individuals were found to have inflammatory bowel disease (IBD) - an important diagnosis with implications for long-term management. BCSP participants should be aware that findings other than neoplasia may be detected and the relevance of these findings to that individual is not known. Reporting of NNF varies between colonoscopists, and potential underreporting is a limitation of this study. Further study is required to establish the impact of NNF on primary and secondary care.</description><subject>Aged</subject><subject>Colonoscopy - statistics & numerical data</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Early Detection of Cancer</subject><subject>Female</subject><subject>Guaiac</subject><subject>Humans</subject><subject>Inflammatory Bowel Diseases - diagnosis</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Middle Aged</subject><subject>Occult Blood</subject><subject>Predictive Value of Tests</subject><subject>Reagent Kits, Diagnostic - standards</subject><issn>0969-1413</issn><issn>1475-5793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1u2zAQhImiQew4vfdU8AWUkKIkkr21rvMDGGmApGdhTS1lGRIpkHSKPELeujKc5hAgpz3MzIfZIeQrZxecS3nJdKV5wQUvylwppT-ROS9kmZVSi89kfpCzgz4jZzHuGGOCc3VKZnlRFQXL9Zy83HmXOfRjDzF1htrONZ1rI4VEje-989H48ZmCTRjo6GOXuiekFtBAT70x-z7RTe99QxNOBNd-p78gAbXBDzRtka5c23dxS3_6v9jTJTgzgR5MQHSTm94H3wYYBjwnJxb6iF9e74L8uVo9Lm-y9e_r2-WPdWaEkClTm01eqkpWkIMqc4m55qAEYtFYqa2qyqkZcFtJwRSrMFcAjUQNUkhlNRcLwo5cE3yMAW09hm6A8FxzVh9Wrd-vOkW-HSPjfjNg8xb4P-NkyI6GCC3WO78PbnrhY-A_q6SBng</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Bevan, Roisin</creator><creator>Lee, Thomas JW</creator><creator>Nickerson, Claire</creator><creator>Rubin, Greg</creator><creator>Rees, Colin J</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201406</creationdate><title>Non-neoplastic findings at colonoscopy after positive faecal occult blood testing: Data from the English Bowel Cancer Screening Programme</title><author>Bevan, Roisin ; Lee, Thomas JW ; Nickerson, Claire ; Rubin, Greg ; Rees, Colin J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-8bb258676a2a8527e291a83ee4df79f865ecaa1f6730806e28aad7e9a7378f913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Colonoscopy - statistics & numerical data</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Early Detection of Cancer</topic><topic>Female</topic><topic>Guaiac</topic><topic>Humans</topic><topic>Inflammatory Bowel Diseases - diagnosis</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Middle Aged</topic><topic>Occult Blood</topic><topic>Predictive Value of Tests</topic><topic>Reagent Kits, Diagnostic - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bevan, Roisin</creatorcontrib><creatorcontrib>Lee, Thomas JW</creatorcontrib><creatorcontrib>Nickerson, Claire</creatorcontrib><creatorcontrib>Rubin, Greg</creatorcontrib><creatorcontrib>Rees, Colin J</creatorcontrib><creatorcontrib>NHS BCSP Evaluation Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of medical screening</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bevan, Roisin</au><au>Lee, Thomas JW</au><au>Nickerson, Claire</au><au>Rubin, Greg</au><au>Rees, Colin J</au><aucorp>NHS BCSP Evaluation Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-neoplastic findings at colonoscopy after positive faecal occult blood testing: Data from the English Bowel Cancer Screening Programme</atitle><jtitle>Journal of medical screening</jtitle><addtitle>J Med Screen</addtitle><date>2014-06</date><risdate>2014</risdate><volume>21</volume><issue>2</issue><spage>89</spage><epage>94</epage><pages>89-94</pages><issn>0969-1413</issn><eissn>1475-5793</eissn><abstract>Background
The aim of the English Bowel Cancer Screening Programme (BCSP) is to diagnose early colorectal cancer and advanced adenomas. However, other findings are also reported at screening colonoscopy. Small studies demonstrate findings other than cancer or adenomas (non-neoplastic findings (NNF)) in 11–25%.
Objectives and setting
Describe the frequency and nature of NNF within the BSCP.
Methods
Data were obtained from the BCSP national database for all individuals undergoing colonoscopic investigation after positive faecal occult blood testing between August 2006 and November 2011. Data included demographics, smoking status, neoplastic findings and NNF.
Results
121728 colonoscopies were analysed. ≥1 NNF were found in 26251 cases (21.6%). Diverticular disease (18875 cases) and haemorrhoids (7011) were the most frequently reported. Inflammatory bowel disease (IBD) was reported in 2152 cases. Individuals with a neoplastic diagnosis were less likely to have an NNF than those without (19.8% v 24.4%, p < 0.001). After adjustment for confounding using multivariable analysis, older age was still associated with a small but statistically significant risk of NNF.
Conclusions
The BCSP generates a significant volume of NNF. A small proportion of individuals were found to have inflammatory bowel disease (IBD) - an important diagnosis with implications for long-term management. BCSP participants should be aware that findings other than neoplasia may be detected and the relevance of these findings to that individual is not known. Reporting of NNF varies between colonoscopists, and potential underreporting is a limitation of this study. Further study is required to establish the impact of NNF on primary and secondary care.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>24644029</pmid><doi>10.1177/0969141314528889</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Colonoscopy - statistics & numerical data Colorectal Neoplasms - diagnosis Early Detection of Cancer Female Guaiac Humans Inflammatory Bowel Diseases - diagnosis Male Mass Screening Middle Aged Occult Blood Predictive Value of Tests Reagent Kits, Diagnostic - standards |
| title | Non-neoplastic findings at colonoscopy after positive faecal occult blood testing: Data from the English Bowel Cancer Screening Programme |
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