Association between DNA ploidy and micronucleus frequency in chronic smokers and impact of smoking cessation
Tobacco use may initiate the process of oral carcinogenesis with clinically undetectable changes. Smoking cessation may prevent its progression. The objective of this study was to evaluate the association between DNA ploidy and micronucleus (MN) frequency in chronic smokers. Three groups were evalua...
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| Veröffentlicht in: | Human & Experimental Toxicology 2021-08, Vol.40 (8), p.1374-1382 |
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| container_title | Human & Experimental Toxicology |
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| creator | Cruz, BS Schwarzmeier, LAT Carvalho, BFDC Alves, MGO Carta, CFL Balducci, I Scholz, JR Almeida, JD |
| description | Tobacco use may initiate the process of oral carcinogenesis with clinically undetectable changes. Smoking cessation may prevent its progression. The objective of this study was to evaluate the association between DNA ploidy and micronucleus (MN) frequency in chronic smokers. Three groups were evaluated: Smoker Group, Former Smoker Group and Control Group. Exfoliative cytology was performed on the lateral border of the tongue and mouth floor. MN and DNA ploidy analyses were performed, as well as the correlation between the variables. The data showed a difference between the groups for the total MN (p = 0.0227), and the Smoker group had the highest mean (4.22 ± 4.12). The three groups did not differ statistically from each other on ploidy evaluation (p-value > 0.05). There was also an association between aneuploidy and increased MN frequency in the Former Smoker group (p = 0.0036). In conclusion, these results point out that there is a relationship between the frequency of MN and aneuploidy in former smokers. Moreover, smoking cessation, even for a short period of time, may promote the decrease of MN frequency caused by tobacco use. |
| doi_str_mv | 10.1177/0960327121991904 |
| format | Article |
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Smoking cessation may prevent its progression. The objective of this study was to evaluate the association between DNA ploidy and micronucleus (MN) frequency in chronic smokers. Three groups were evaluated: Smoker Group, Former Smoker Group and Control Group. Exfoliative cytology was performed on the lateral border of the tongue and mouth floor. MN and DNA ploidy analyses were performed, as well as the correlation between the variables. The data showed a difference between the groups for the total MN (p = 0.0227), and the Smoker group had the highest mean (4.22 ± 4.12). The three groups did not differ statistically from each other on ploidy evaluation (p-value > 0.05). There was also an association between aneuploidy and increased MN frequency in the Former Smoker group (p = 0.0036). In conclusion, these results point out that there is a relationship between the frequency of MN and aneuploidy in former smokers. Moreover, smoking cessation, even for a short period of time, may promote the decrease of MN frequency caused by tobacco use.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/0960327121991904</identifier><identifier>PMID: 33541126</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aneuploidy ; Carcinogenesis ; Carcinogens ; Cigarette smoking ; Cytology ; Deoxyribonucleic acid ; DNA ; Drug addiction ; Female ; Humans ; Male ; Micronuclei, Chromosome-Defective ; Micronucleus Tests ; Ploidy ; Smokers ; Smoking ; Smoking - genetics ; Smoking Cessation ; Tobacco</subject><ispartof>Human & Experimental Toxicology, 2021-08, Vol.40 (8), p.1374-1382</ispartof><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-226f83fce50df135702649e6e14b6a0b83000e4546b924f7e0ced3472e2f9fa33</citedby><cites>FETCH-LOGICAL-c365t-226f83fce50df135702649e6e14b6a0b83000e4546b924f7e0ced3472e2f9fa33</cites><orcidid>0000-0002-3026-7705</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0960327121991904$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0960327121991904$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>313,314,776,780,788,21946,27832,27901,27903,27904,44924,45312</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0960327121991904?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33541126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cruz, BS</creatorcontrib><creatorcontrib>Schwarzmeier, LAT</creatorcontrib><creatorcontrib>Carvalho, BFDC</creatorcontrib><creatorcontrib>Alves, MGO</creatorcontrib><creatorcontrib>Carta, CFL</creatorcontrib><creatorcontrib>Balducci, I</creatorcontrib><creatorcontrib>Scholz, JR</creatorcontrib><creatorcontrib>Almeida, JD</creatorcontrib><title>Association between DNA ploidy and micronucleus frequency in chronic smokers and impact of smoking cessation</title><title>Human & Experimental Toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>Tobacco use may initiate the process of oral carcinogenesis with clinically undetectable changes. Smoking cessation may prevent its progression. The objective of this study was to evaluate the association between DNA ploidy and micronucleus (MN) frequency in chronic smokers. Three groups were evaluated: Smoker Group, Former Smoker Group and Control Group. Exfoliative cytology was performed on the lateral border of the tongue and mouth floor. MN and DNA ploidy analyses were performed, as well as the correlation between the variables. The data showed a difference between the groups for the total MN (p = 0.0227), and the Smoker group had the highest mean (4.22 ± 4.12). The three groups did not differ statistically from each other on ploidy evaluation (p-value > 0.05). There was also an association between aneuploidy and increased MN frequency in the Former Smoker group (p = 0.0036). In conclusion, these results point out that there is a relationship between the frequency of MN and aneuploidy in former smokers. Moreover, smoking cessation, even for a short period of time, may promote the decrease of MN frequency caused by tobacco use.</description><subject>Aneuploidy</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Cigarette smoking</subject><subject>Cytology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug addiction</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Micronuclei, Chromosome-Defective</subject><subject>Micronucleus Tests</subject><subject>Ploidy</subject><subject>Smokers</subject><subject>Smoking</subject><subject>Smoking - genetics</subject><subject>Smoking Cessation</subject><subject>Tobacco</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPwzAQhC0EoqVw54QscQ74FTs-VuUpVXCBc5Q46-KSOCVOhPrvcR-AhMTJkufbmd1B6JySK0qVuiZaEs4UZVRrqok4QGMqlEqIJvwQjTdystFH6CSEJSFE6pQeoxHnqaCUyTGqpyG0xhW9az0uof8E8PjmaYpXdeuqNS58hRtnutYPpoYhYNvBxwDerLHz2LxFwRkcmvYdurClXbMqTI9bu_11foENhLANOEVHtqgDnO3fCXq9u32ZPSTz5_vH2XSeGC7TPmFM2oxbAympLOWpIkwKDRKoKGVByozHS0CkQpaaCauAGKi4UAyY1bbgfIIud76rro3Lhj5ftkPnY2TO0pQrqjOeRYrsqHhdCB3YfNW5pujWOSX5pt78b71x5GJvPJQNVD8D331GINkBoVjAb-q_hl_Jj4JR</recordid><startdate>202108</startdate><enddate>202108</enddate><creator>Cruz, BS</creator><creator>Schwarzmeier, LAT</creator><creator>Carvalho, BFDC</creator><creator>Alves, MGO</creator><creator>Carta, CFL</creator><creator>Balducci, I</creator><creator>Scholz, JR</creator><creator>Almeida, JD</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0002-3026-7705</orcidid></search><sort><creationdate>202108</creationdate><title>Association between DNA ploidy and micronucleus frequency in chronic smokers and impact of smoking cessation</title><author>Cruz, BS ; Schwarzmeier, LAT ; Carvalho, BFDC ; Alves, MGO ; Carta, CFL ; Balducci, I ; Scholz, JR ; Almeida, JD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-226f83fce50df135702649e6e14b6a0b83000e4546b924f7e0ced3472e2f9fa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aneuploidy</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Cigarette smoking</topic><topic>Cytology</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug addiction</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Micronuclei, Chromosome-Defective</topic><topic>Micronucleus Tests</topic><topic>Ploidy</topic><topic>Smokers</topic><topic>Smoking</topic><topic>Smoking - genetics</topic><topic>Smoking Cessation</topic><topic>Tobacco</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cruz, BS</creatorcontrib><creatorcontrib>Schwarzmeier, LAT</creatorcontrib><creatorcontrib>Carvalho, BFDC</creatorcontrib><creatorcontrib>Alves, MGO</creatorcontrib><creatorcontrib>Carta, CFL</creatorcontrib><creatorcontrib>Balducci, I</creatorcontrib><creatorcontrib>Scholz, JR</creatorcontrib><creatorcontrib>Almeida, JD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Environment Abstracts</collection><jtitle>Human & Experimental Toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Cruz, BS</au><au>Schwarzmeier, LAT</au><au>Carvalho, BFDC</au><au>Alves, MGO</au><au>Carta, CFL</au><au>Balducci, I</au><au>Scholz, JR</au><au>Almeida, JD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between DNA ploidy and micronucleus frequency in chronic smokers and impact of smoking cessation</atitle><jtitle>Human & Experimental Toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2021-08</date><risdate>2021</risdate><volume>40</volume><issue>8</issue><spage>1374</spage><epage>1382</epage><pages>1374-1382</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>Tobacco use may initiate the process of oral carcinogenesis with clinically undetectable changes. Smoking cessation may prevent its progression. The objective of this study was to evaluate the association between DNA ploidy and micronucleus (MN) frequency in chronic smokers. Three groups were evaluated: Smoker Group, Former Smoker Group and Control Group. Exfoliative cytology was performed on the lateral border of the tongue and mouth floor. MN and DNA ploidy analyses were performed, as well as the correlation between the variables. The data showed a difference between the groups for the total MN (p = 0.0227), and the Smoker group had the highest mean (4.22 ± 4.12). The three groups did not differ statistically from each other on ploidy evaluation (p-value > 0.05). There was also an association between aneuploidy and increased MN frequency in the Former Smoker group (p = 0.0036). In conclusion, these results point out that there is a relationship between the frequency of MN and aneuploidy in former smokers. Moreover, smoking cessation, even for a short period of time, may promote the decrease of MN frequency caused by tobacco use.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>33541126</pmid><doi>10.1177/0960327121991904</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3026-7705</orcidid></addata></record> |
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| ispartof | Human & Experimental Toxicology, 2021-08, Vol.40 (8), p.1374-1382 |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Aneuploidy Carcinogenesis Carcinogens Cigarette smoking Cytology Deoxyribonucleic acid DNA Drug addiction Female Humans Male Micronuclei, Chromosome-Defective Micronucleus Tests Ploidy Smokers Smoking Smoking - genetics Smoking Cessation Tobacco |
| title | Association between DNA ploidy and micronucleus frequency in chronic smokers and impact of smoking cessation |
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