Topically Applied Cmt-2 Enhances Wound Healing in Streptozotocin Diabetic Rat Skin
Delayed wound healing is one of the complications of diabetes mellitus, exhibited by increased wound collagenase and decreased granulation tissues. The current study compared wound healing in normal and diabetic rats, and the effects of topically applied 1 % or 3% concentrations of chemically modifi...
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| Veröffentlicht in: | Advances in dental research 1998-11, Vol.12 (1), p.144-148 |
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| container_title | Advances in dental research |
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| creator | Ramamurthy, N.S. Kucine, A.J. McClain, S.A. McNamara, T.F. Golub, L.M. |
| description | Delayed wound healing is one of the complications of diabetes mellitus, exhibited by increased wound collagenase and decreased granulation tissues. The current study compared wound healing in normal and diabetic rats, and the effects of topically applied 1 % or 3% concentrations of chemically modified tetracycline-2 (CMT-2) on 6-mm circular full-thickness skin wounds healed by secondary intention. On day 7 after wounding, tissues were removed for biochemical analysis and histology. The wound granulation tissue hydroxyproline was less in the untreated diabetic rat with increased collagenase and gelatinase. Treating the diabetic rat wounds with 3% CMT-2 increased the wound hydroxyproline and decreased activities of gelatinase and collagenase. There was a delay in wound filling by granulation tissue in diabetic rats. In CMT-2-treated diabetic rats, the volume of granulation tissue was greater than that in untreated diabetic rats. CMT-2 appears to normalize wound healing in diabetic rats and may be a valuable adjunct in the treatment of chronic wounds. |
| doi_str_mv | 10.1177/08959374980120011001 |
| format | Article |
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The current study compared wound healing in normal and diabetic rats, and the effects of topically applied 1 % or 3% concentrations of chemically modified tetracycline-2 (CMT-2) on 6-mm circular full-thickness skin wounds healed by secondary intention. On day 7 after wounding, tissues were removed for biochemical analysis and histology. The wound granulation tissue hydroxyproline was less in the untreated diabetic rat with increased collagenase and gelatinase. Treating the diabetic rat wounds with 3% CMT-2 increased the wound hydroxyproline and decreased activities of gelatinase and collagenase. There was a delay in wound filling by granulation tissue in diabetic rats. In CMT-2-treated diabetic rats, the volume of granulation tissue was greater than that in untreated diabetic rats. 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The current study compared wound healing in normal and diabetic rats, and the effects of topically applied 1 % or 3% concentrations of chemically modified tetracycline-2 (CMT-2) on 6-mm circular full-thickness skin wounds healed by secondary intention. On day 7 after wounding, tissues were removed for biochemical analysis and histology. The wound granulation tissue hydroxyproline was less in the untreated diabetic rat with increased collagenase and gelatinase. Treating the diabetic rat wounds with 3% CMT-2 increased the wound hydroxyproline and decreased activities of gelatinase and collagenase. There was a delay in wound filling by granulation tissue in diabetic rats. In CMT-2-treated diabetic rats, the volume of granulation tissue was greater than that in untreated diabetic rats. CMT-2 appears to normalize wound healing in diabetic rats and may be a valuable adjunct in the treatment of chronic wounds.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Collagenases - metabolism</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Gelatinases - metabolism</subject><subject>Granulation Tissue - drug effects</subject><subject>Hydroxyproline - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Skin - injuries</subject><subject>Skin - metabolism</subject><subject>Streptozocin</subject><subject>Tetracyclines - administration & dosage</subject><subject>Tetracyclines - pharmacology</subject><subject>Wound Healing - drug effects</subject><issn>0895-9374</issn><issn>1544-0737</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UF1LwzAUDaLMOf0HCvkD1dwkbZLHMTcnDIRt4mO5TdOZ2bWl6R7mr7djwyfx4XK4nA84h5B7YI8ASj0xbWIjlDSaAWcMoL8LMoRYyogpoS7J8CiJjpprchPCljHOgesBGRijOAgzJMt13XiLZXmg46YpvcvpZNdFnE6rT6ysC_Sj3lc5nTssfbWhvqKrrnVNV3_XXW3799lj5jpv6RI7uvry1S25KrAM7u6MI_I-m64n82jx9vI6GS8iy2PTRVYIq3PMcicgYTbmPaIFmyUitoVWKFnCC17EMVonRCISlApkoYVGdNKIEZGnXNvWIbSuSJvW77A9pMDS40LpXwv1toeTrdlnO5f_ms6T9Dyc-IAbl27rfVv1Lf7P_AHgVW5f</recordid><startdate>199811</startdate><enddate>199811</enddate><creator>Ramamurthy, N.S.</creator><creator>Kucine, A.J.</creator><creator>McClain, S.A.</creator><creator>McNamara, T.F.</creator><creator>Golub, L.M.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199811</creationdate><title>Topically Applied Cmt-2 Enhances Wound Healing in Streptozotocin Diabetic Rat Skin</title><author>Ramamurthy, N.S. ; Kucine, A.J. ; McClain, S.A. ; McNamara, T.F. ; Golub, L.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c259t-c33c8dabde3160c52e31ac1cb635cf87a4062f2f55ace33636a4714f838aae493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Topical</topic><topic>Animals</topic><topic>Collagenases - metabolism</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Gelatinases - metabolism</topic><topic>Granulation Tissue - drug effects</topic><topic>Hydroxyproline - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Skin - injuries</topic><topic>Skin - metabolism</topic><topic>Streptozocin</topic><topic>Tetracyclines - administration & dosage</topic><topic>Tetracyclines - pharmacology</topic><topic>Wound Healing - drug effects</topic><toplevel>online_resources</toplevel><creatorcontrib>Ramamurthy, N.S.</creatorcontrib><creatorcontrib>Kucine, A.J.</creatorcontrib><creatorcontrib>McClain, S.A.</creatorcontrib><creatorcontrib>McNamara, T.F.</creatorcontrib><creatorcontrib>Golub, L.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Advances in dental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramamurthy, N.S.</au><au>Kucine, A.J.</au><au>McClain, S.A.</au><au>McNamara, T.F.</au><au>Golub, L.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topically Applied Cmt-2 Enhances Wound Healing in Streptozotocin Diabetic Rat Skin</atitle><jtitle>Advances in dental research</jtitle><addtitle>Adv Dent Res</addtitle><date>1998-11</date><risdate>1998</risdate><volume>12</volume><issue>1</issue><spage>144</spage><epage>148</epage><pages>144-148</pages><issn>0895-9374</issn><eissn>1544-0737</eissn><abstract>Delayed wound healing is one of the complications of diabetes mellitus, exhibited by increased wound collagenase and decreased granulation tissues. The current study compared wound healing in normal and diabetic rats, and the effects of topically applied 1 % or 3% concentrations of chemically modified tetracycline-2 (CMT-2) on 6-mm circular full-thickness skin wounds healed by secondary intention. On day 7 after wounding, tissues were removed for biochemical analysis and histology. The wound granulation tissue hydroxyproline was less in the untreated diabetic rat with increased collagenase and gelatinase. Treating the diabetic rat wounds with 3% CMT-2 increased the wound hydroxyproline and decreased activities of gelatinase and collagenase. There was a delay in wound filling by granulation tissue in diabetic rats. In CMT-2-treated diabetic rats, the volume of granulation tissue was greater than that in untreated diabetic rats. CMT-2 appears to normalize wound healing in diabetic rats and may be a valuable adjunct in the treatment of chronic wounds.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>9972139</pmid><doi>10.1177/08959374980120011001</doi><tpages>5</tpages></addata></record> |
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| ispartof | Advances in dental research, 1998-11, Vol.12 (1), p.144-148 |
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| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Administration, Topical Animals Collagenases - metabolism Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - physiopathology Gelatinases - metabolism Granulation Tissue - drug effects Hydroxyproline - metabolism Male Rats Rats, Sprague-Dawley Skin - injuries Skin - metabolism Streptozocin Tetracyclines - administration & dosage Tetracyclines - pharmacology Wound Healing - drug effects |
| title | Topically Applied Cmt-2 Enhances Wound Healing in Streptozotocin Diabetic Rat Skin |
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