The role of preoperative immune cell metrics in renal cell carcinoma with a tumor thrombus
Introduction: The objective of this study was to stratify preoperative immune cell counts by cancer specific outcomes in patients with renal cell carcinoma (RCC) and a tumor thrombus after radical nephrectomy with tumor thrombectomy. Methods: Patients with a diagnosis of RCC with tumor thrombus that...
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| Veröffentlicht in: | Urologia 2024-08, Vol.91 (3), p.477-485 |
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| creator | Sandberg, Maxwell Namugosa, Mary Ritts, Rory Costa, Claudia Marie Temple, Davis Hayes, Mitchell Whitman, Wyatt Ye, Emily Refugia, Justin Ben-David, Reuben Alerasool, Parissa Eilender, Benjamin Zanotti, Rafael Ribeiro Mourão, Thiago Camelo Kim, Jung Kwon Marchiñena, Patricio Garcia Byun, Seok-Soo Abreu, Diego Mehrazin, Reza Spiess, Philippe de Cassio Zequi, Stenio Rodriguez, Alejandro |
| description | Introduction:
The objective of this study was to stratify preoperative immune cell counts by cancer specific outcomes in patients with renal cell carcinoma (RCC) and a tumor thrombus after radical nephrectomy with tumor thrombectomy.
Methods:
Patients with a diagnosis of RCC with tumor thrombus that underwent radical nephrectomy with thrombectomy across an international consortium of seven institutions were included. Patients who were metastatic at diagnosis and those who received preoperative medical treatment were also included. Retrospective chart review was performed to collect demographic information, past medical history, preoperative lab work, surgical pathology, and follow up data. Neutrophil counts, lymphocyte counts, monocyte counts, neutrophil to lymphocyte ratios (NLR), lymphocyte to monocyte ratios (LMR), and neutrophil to monocyte ratios (NMR) were compared against cancer-specific outcomes using independent samples t-test, Pearson’s bivariate correlation, and analysis of variance.
Results:
One hundred forty-four patients were included in the study, including nine patients who were metastatic at the time of surgery. Absolute lymphocyte count preoperatively was greater in patients who died from RCC compared to those who did not (2 vs 1.4; p |
| doi_str_mv | 10.1177/03915603241248020 |
| format | Article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_03915603241248020</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_03915603241248020</sage_id><sourcerecordid>10.1177_03915603241248020</sourcerecordid><originalsourceid>FETCH-LOGICAL-c292t-602a58532cfd840a48bcf551a6de565fc9f726617de348b64df5c7a61f1f232b3</originalsourceid><addsrcrecordid>eNp9UF1LwzAUDaK4MfcDfJH8gc58NGn3KEOdMPBlvvhS0vTGZTRNSVrFf29G1RfB-3Lhng_OPQhdU7KitChuCV9TIQlnOWV5SRg5Q3NasDyTpBDnaH7CsxNhhpYxHkkaSVjO-CWa8VJKSko2R6_7A-DgW8De4D6A7yGowb4Dts6NHWANbYsdDMHqiG2HA3Sqna5aBW077xT-sMMBKzyMzgc8HIJ39Riv0IVRbYTl916gl4f7_Wab7Z4fnzZ3u0yzNRtSXKZEKTjTpilzovKy1kYIqmQDQgqj16ZgKW7RAE-YzBsjdKEkNdQwzmq-QHTy1cHHGMBUfbBOhc-KkupUVfWnqqS5mTT9WDtofhU_xSTCaiJE9QbV0Y8hvR3_cfwCx05w6w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The role of preoperative immune cell metrics in renal cell carcinoma with a tumor thrombus</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Sandberg, Maxwell ; Namugosa, Mary ; Ritts, Rory ; Costa, Claudia Marie ; Temple, Davis ; Hayes, Mitchell ; Whitman, Wyatt ; Ye, Emily ; Refugia, Justin ; Ben-David, Reuben ; Alerasool, Parissa ; Eilender, Benjamin ; Zanotti, Rafael Ribeiro ; Mourão, Thiago Camelo ; Kim, Jung Kwon ; Marchiñena, Patricio Garcia ; Byun, Seok-Soo ; Abreu, Diego ; Mehrazin, Reza ; Spiess, Philippe ; de Cassio Zequi, Stenio ; Rodriguez, Alejandro</creator><creatorcontrib>Sandberg, Maxwell ; Namugosa, Mary ; Ritts, Rory ; Costa, Claudia Marie ; Temple, Davis ; Hayes, Mitchell ; Whitman, Wyatt ; Ye, Emily ; Refugia, Justin ; Ben-David, Reuben ; Alerasool, Parissa ; Eilender, Benjamin ; Zanotti, Rafael Ribeiro ; Mourão, Thiago Camelo ; Kim, Jung Kwon ; Marchiñena, Patricio Garcia ; Byun, Seok-Soo ; Abreu, Diego ; Mehrazin, Reza ; Spiess, Philippe ; de Cassio Zequi, Stenio ; Rodriguez, Alejandro</creatorcontrib><description>Introduction:
The objective of this study was to stratify preoperative immune cell counts by cancer specific outcomes in patients with renal cell carcinoma (RCC) and a tumor thrombus after radical nephrectomy with tumor thrombectomy.
Methods:
Patients with a diagnosis of RCC with tumor thrombus that underwent radical nephrectomy with thrombectomy across an international consortium of seven institutions were included. Patients who were metastatic at diagnosis and those who received preoperative medical treatment were also included. Retrospective chart review was performed to collect demographic information, past medical history, preoperative lab work, surgical pathology, and follow up data. Neutrophil counts, lymphocyte counts, monocyte counts, neutrophil to lymphocyte ratios (NLR), lymphocyte to monocyte ratios (LMR), and neutrophil to monocyte ratios (NMR) were compared against cancer-specific outcomes using independent samples t-test, Pearson’s bivariate correlation, and analysis of variance.
Results:
One hundred forty-four patients were included in the study, including nine patients who were metastatic at the time of surgery. Absolute lymphocyte count preoperatively was greater in patients who died from RCC compared to those who did not (2 vs 1.4; p < 0.001). Patients with tumor pathology showing perirenal fat invasion had a greater neutrophil count compared to those who did not (7.5 vs 5.5; p = 0.010). Patients with metastatic RCC had a lower LMR compared to those without metastases after surgery (2.5 vs 3.2; p = 0.041). Tumor size, both preoperatively and on gross specimen, had an interaction with multiple immune cell metrics (p < 0.05).
Conclusions:
Preoperative immune metrics have clinical utility in predicting cancer-specific outcomes for patients with RCC and a tumor thrombus. Additional study is needed to determine the added value of preoperative serum immune cell data to established prognostic risk calculators for this patient population.</description><identifier>ISSN: 0391-5603</identifier><identifier>EISSN: 1724-6075</identifier><identifier>DOI: 10.1177/03915603241248020</identifier><identifier>PMID: 38661082</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Carcinoma, Renal Cell - immunology ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - surgery ; Female ; Humans ; Kidney Neoplasms - immunology ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Leukocyte Count ; Lymphocyte Count ; Male ; Middle Aged ; Monocytes - immunology ; Neoplastic Cells, Circulating ; Nephrectomy ; Neutrophils ; Preoperative Period ; Retrospective Studies ; Thrombectomy ; Thrombosis - etiology ; Thrombosis - immunology</subject><ispartof>Urologia, 2024-08, Vol.91 (3), p.477-485</ispartof><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c292t-602a58532cfd840a48bcf551a6de565fc9f726617de348b64df5c7a61f1f232b3</cites><orcidid>0000-0002-8946-1035 ; 0000-0001-6591-8275 ; 0000-0003-2880-1857</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/03915603241248020$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/03915603241248020$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21823,27928,27929,43625,43626</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38661082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sandberg, Maxwell</creatorcontrib><creatorcontrib>Namugosa, Mary</creatorcontrib><creatorcontrib>Ritts, Rory</creatorcontrib><creatorcontrib>Costa, Claudia Marie</creatorcontrib><creatorcontrib>Temple, Davis</creatorcontrib><creatorcontrib>Hayes, Mitchell</creatorcontrib><creatorcontrib>Whitman, Wyatt</creatorcontrib><creatorcontrib>Ye, Emily</creatorcontrib><creatorcontrib>Refugia, Justin</creatorcontrib><creatorcontrib>Ben-David, Reuben</creatorcontrib><creatorcontrib>Alerasool, Parissa</creatorcontrib><creatorcontrib>Eilender, Benjamin</creatorcontrib><creatorcontrib>Zanotti, Rafael Ribeiro</creatorcontrib><creatorcontrib>Mourão, Thiago Camelo</creatorcontrib><creatorcontrib>Kim, Jung Kwon</creatorcontrib><creatorcontrib>Marchiñena, Patricio Garcia</creatorcontrib><creatorcontrib>Byun, Seok-Soo</creatorcontrib><creatorcontrib>Abreu, Diego</creatorcontrib><creatorcontrib>Mehrazin, Reza</creatorcontrib><creatorcontrib>Spiess, Philippe</creatorcontrib><creatorcontrib>de Cassio Zequi, Stenio</creatorcontrib><creatorcontrib>Rodriguez, Alejandro</creatorcontrib><title>The role of preoperative immune cell metrics in renal cell carcinoma with a tumor thrombus</title><title>Urologia</title><addtitle>Urologia</addtitle><description>Introduction:
The objective of this study was to stratify preoperative immune cell counts by cancer specific outcomes in patients with renal cell carcinoma (RCC) and a tumor thrombus after radical nephrectomy with tumor thrombectomy.
Methods:
Patients with a diagnosis of RCC with tumor thrombus that underwent radical nephrectomy with thrombectomy across an international consortium of seven institutions were included. Patients who were metastatic at diagnosis and those who received preoperative medical treatment were also included. Retrospective chart review was performed to collect demographic information, past medical history, preoperative lab work, surgical pathology, and follow up data. Neutrophil counts, lymphocyte counts, monocyte counts, neutrophil to lymphocyte ratios (NLR), lymphocyte to monocyte ratios (LMR), and neutrophil to monocyte ratios (NMR) were compared against cancer-specific outcomes using independent samples t-test, Pearson’s bivariate correlation, and analysis of variance.
Results:
One hundred forty-four patients were included in the study, including nine patients who were metastatic at the time of surgery. Absolute lymphocyte count preoperatively was greater in patients who died from RCC compared to those who did not (2 vs 1.4; p < 0.001). Patients with tumor pathology showing perirenal fat invasion had a greater neutrophil count compared to those who did not (7.5 vs 5.5; p = 0.010). Patients with metastatic RCC had a lower LMR compared to those without metastases after surgery (2.5 vs 3.2; p = 0.041). Tumor size, both preoperatively and on gross specimen, had an interaction with multiple immune cell metrics (p < 0.05).
Conclusions:
Preoperative immune metrics have clinical utility in predicting cancer-specific outcomes for patients with RCC and a tumor thrombus. Additional study is needed to determine the added value of preoperative serum immune cell data to established prognostic risk calculators for this patient population.</description><subject>Aged</subject><subject>Carcinoma, Renal Cell - immunology</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Neoplasms - immunology</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Leukocyte Count</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monocytes - immunology</subject><subject>Neoplastic Cells, Circulating</subject><subject>Nephrectomy</subject><subject>Neutrophils</subject><subject>Preoperative Period</subject><subject>Retrospective Studies</subject><subject>Thrombectomy</subject><subject>Thrombosis - etiology</subject><subject>Thrombosis - immunology</subject><issn>0391-5603</issn><issn>1724-6075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UF1LwzAUDaK4MfcDfJH8gc58NGn3KEOdMPBlvvhS0vTGZTRNSVrFf29G1RfB-3Lhng_OPQhdU7KitChuCV9TIQlnOWV5SRg5Q3NasDyTpBDnaH7CsxNhhpYxHkkaSVjO-CWa8VJKSko2R6_7A-DgW8De4D6A7yGowb4Dts6NHWANbYsdDMHqiG2HA3Sqna5aBW077xT-sMMBKzyMzgc8HIJ39Riv0IVRbYTl916gl4f7_Wab7Z4fnzZ3u0yzNRtSXKZEKTjTpilzovKy1kYIqmQDQgqj16ZgKW7RAE-YzBsjdKEkNdQwzmq-QHTy1cHHGMBUfbBOhc-KkupUVfWnqqS5mTT9WDtofhU_xSTCaiJE9QbV0Y8hvR3_cfwCx05w6w</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Sandberg, Maxwell</creator><creator>Namugosa, Mary</creator><creator>Ritts, Rory</creator><creator>Costa, Claudia Marie</creator><creator>Temple, Davis</creator><creator>Hayes, Mitchell</creator><creator>Whitman, Wyatt</creator><creator>Ye, Emily</creator><creator>Refugia, Justin</creator><creator>Ben-David, Reuben</creator><creator>Alerasool, Parissa</creator><creator>Eilender, Benjamin</creator><creator>Zanotti, Rafael Ribeiro</creator><creator>Mourão, Thiago Camelo</creator><creator>Kim, Jung Kwon</creator><creator>Marchiñena, Patricio Garcia</creator><creator>Byun, Seok-Soo</creator><creator>Abreu, Diego</creator><creator>Mehrazin, Reza</creator><creator>Spiess, Philippe</creator><creator>de Cassio Zequi, Stenio</creator><creator>Rodriguez, Alejandro</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-8946-1035</orcidid><orcidid>https://orcid.org/0000-0001-6591-8275</orcidid><orcidid>https://orcid.org/0000-0003-2880-1857</orcidid></search><sort><creationdate>20240801</creationdate><title>The role of preoperative immune cell metrics in renal cell carcinoma with a tumor thrombus</title><author>Sandberg, Maxwell ; Namugosa, Mary ; Ritts, Rory ; Costa, Claudia Marie ; Temple, Davis ; Hayes, Mitchell ; Whitman, Wyatt ; Ye, Emily ; Refugia, Justin ; Ben-David, Reuben ; Alerasool, Parissa ; Eilender, Benjamin ; Zanotti, Rafael Ribeiro ; Mourão, Thiago Camelo ; Kim, Jung Kwon ; Marchiñena, Patricio Garcia ; Byun, Seok-Soo ; Abreu, Diego ; Mehrazin, Reza ; Spiess, Philippe ; de Cassio Zequi, Stenio ; Rodriguez, Alejandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-602a58532cfd840a48bcf551a6de565fc9f726617de348b64df5c7a61f1f232b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Carcinoma, Renal Cell - immunology</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Carcinoma, Renal Cell - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Neoplasms - immunology</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Leukocyte Count</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monocytes - immunology</topic><topic>Neoplastic Cells, Circulating</topic><topic>Nephrectomy</topic><topic>Neutrophils</topic><topic>Preoperative Period</topic><topic>Retrospective Studies</topic><topic>Thrombectomy</topic><topic>Thrombosis - etiology</topic><topic>Thrombosis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sandberg, Maxwell</creatorcontrib><creatorcontrib>Namugosa, Mary</creatorcontrib><creatorcontrib>Ritts, Rory</creatorcontrib><creatorcontrib>Costa, Claudia Marie</creatorcontrib><creatorcontrib>Temple, Davis</creatorcontrib><creatorcontrib>Hayes, Mitchell</creatorcontrib><creatorcontrib>Whitman, Wyatt</creatorcontrib><creatorcontrib>Ye, Emily</creatorcontrib><creatorcontrib>Refugia, Justin</creatorcontrib><creatorcontrib>Ben-David, Reuben</creatorcontrib><creatorcontrib>Alerasool, Parissa</creatorcontrib><creatorcontrib>Eilender, Benjamin</creatorcontrib><creatorcontrib>Zanotti, Rafael Ribeiro</creatorcontrib><creatorcontrib>Mourão, Thiago Camelo</creatorcontrib><creatorcontrib>Kim, Jung Kwon</creatorcontrib><creatorcontrib>Marchiñena, Patricio Garcia</creatorcontrib><creatorcontrib>Byun, Seok-Soo</creatorcontrib><creatorcontrib>Abreu, Diego</creatorcontrib><creatorcontrib>Mehrazin, Reza</creatorcontrib><creatorcontrib>Spiess, Philippe</creatorcontrib><creatorcontrib>de Cassio Zequi, Stenio</creatorcontrib><creatorcontrib>Rodriguez, Alejandro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Urologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sandberg, Maxwell</au><au>Namugosa, Mary</au><au>Ritts, Rory</au><au>Costa, Claudia Marie</au><au>Temple, Davis</au><au>Hayes, Mitchell</au><au>Whitman, Wyatt</au><au>Ye, Emily</au><au>Refugia, Justin</au><au>Ben-David, Reuben</au><au>Alerasool, Parissa</au><au>Eilender, Benjamin</au><au>Zanotti, Rafael Ribeiro</au><au>Mourão, Thiago Camelo</au><au>Kim, Jung Kwon</au><au>Marchiñena, Patricio Garcia</au><au>Byun, Seok-Soo</au><au>Abreu, Diego</au><au>Mehrazin, Reza</au><au>Spiess, Philippe</au><au>de Cassio Zequi, Stenio</au><au>Rodriguez, Alejandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of preoperative immune cell metrics in renal cell carcinoma with a tumor thrombus</atitle><jtitle>Urologia</jtitle><addtitle>Urologia</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>91</volume><issue>3</issue><spage>477</spage><epage>485</epage><pages>477-485</pages><issn>0391-5603</issn><eissn>1724-6075</eissn><abstract>Introduction:
The objective of this study was to stratify preoperative immune cell counts by cancer specific outcomes in patients with renal cell carcinoma (RCC) and a tumor thrombus after radical nephrectomy with tumor thrombectomy.
Methods:
Patients with a diagnosis of RCC with tumor thrombus that underwent radical nephrectomy with thrombectomy across an international consortium of seven institutions were included. Patients who were metastatic at diagnosis and those who received preoperative medical treatment were also included. Retrospective chart review was performed to collect demographic information, past medical history, preoperative lab work, surgical pathology, and follow up data. Neutrophil counts, lymphocyte counts, monocyte counts, neutrophil to lymphocyte ratios (NLR), lymphocyte to monocyte ratios (LMR), and neutrophil to monocyte ratios (NMR) were compared against cancer-specific outcomes using independent samples t-test, Pearson’s bivariate correlation, and analysis of variance.
Results:
One hundred forty-four patients were included in the study, including nine patients who were metastatic at the time of surgery. Absolute lymphocyte count preoperatively was greater in patients who died from RCC compared to those who did not (2 vs 1.4; p < 0.001). Patients with tumor pathology showing perirenal fat invasion had a greater neutrophil count compared to those who did not (7.5 vs 5.5; p = 0.010). Patients with metastatic RCC had a lower LMR compared to those without metastases after surgery (2.5 vs 3.2; p = 0.041). Tumor size, both preoperatively and on gross specimen, had an interaction with multiple immune cell metrics (p < 0.05).
Conclusions:
Preoperative immune metrics have clinical utility in predicting cancer-specific outcomes for patients with RCC and a tumor thrombus. Additional study is needed to determine the added value of preoperative serum immune cell data to established prognostic risk calculators for this patient population.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>38661082</pmid><doi>10.1177/03915603241248020</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8946-1035</orcidid><orcidid>https://orcid.org/0000-0001-6591-8275</orcidid><orcidid>https://orcid.org/0000-0003-2880-1857</orcidid></addata></record> |
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| ispartof | Urologia, 2024-08, Vol.91 (3), p.477-485 |
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| language | eng |
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| subjects | Aged Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - surgery Female Humans Kidney Neoplasms - immunology Kidney Neoplasms - pathology Kidney Neoplasms - surgery Leukocyte Count Lymphocyte Count Male Middle Aged Monocytes - immunology Neoplastic Cells, Circulating Nephrectomy Neutrophils Preoperative Period Retrospective Studies Thrombectomy Thrombosis - etiology Thrombosis - immunology |
| title | The role of preoperative immune cell metrics in renal cell carcinoma with a tumor thrombus |
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