Evaluation of tadalafil supplementation on the neutrophil/lymphocyte and the platelet/lymphocyte ratios in patients with erectile dysfunction: A prospective study
Objectives: We aimed to evaluate the effect of daily 5 mg tadalafil on the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) in patients with erectile dysfunction (ED). Patients and methods: 30 subjects with ED were given tadalafil as well as 30 subjects with ED who were not...
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| Veröffentlicht in: | Urologia 2024-08, Vol.91 (3), p.598-603 |
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| container_title | Urologia |
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| creator | GamalEl Din, Sameh Fayek Nabil Ismail, Nashaat Moawad, Hanan Hosni Adel, Iten Mohamed Motawi, Ahmad Foaad, Hisham |
| description | Objectives:
We aimed to evaluate the effect of daily 5 mg tadalafil on the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) in patients with erectile dysfunction (ED).
Patients and methods:
30 subjects with ED were given tadalafil as well as 30 subjects with ED who were not receiving tadalafil were recruited. 30 healthy individuals served as controls.
Results:
Receiver operating characteristic curve (ROC) showed that the best cut off point of pre-treatment and post treatment NLR in the ED treatment group was found |
| doi_str_mv | 10.1177/03915603241240649 |
| format | Article |
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We aimed to evaluate the effect of daily 5 mg tadalafil on the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) in patients with erectile dysfunction (ED).
Patients and methods:
30 subjects with ED were given tadalafil as well as 30 subjects with ED who were not receiving tadalafil were recruited. 30 healthy individuals served as controls.
Results:
Receiver operating characteristic curve (ROC) showed that the best cut off point of pre-treatment and post treatment NLR in the ED treatment group was found <1.51, <1.51, sensitivity of 68.3%, 58.3%, specificity of 53.3%, 53.3%, lower bound of 0.558, 0.517, upper bound of 0.789, 0.757, total accuracy of 67.4%, 63.7% and p 0.003, 0.0025, respectively. Additionally, the best cut off point of pre-treatment and post treatment PLR in the ED treatment group was found <5.89, <5.99, sensitivity of 65%, 63.3%, specificity of 63.3%, 53.3%, lower bound of 0.515, 0.435, upper bound of 0.755, 0.687, total accuracy of 63.5%, 56.1% and p 0.027, 0.341, respectively.
Conclusion:
Daily 5 mg Tadalafil supplementation significantly improves erectile function through decreasing these markers as well as depression and anxiety.</description><identifier>ISSN: 0391-5603</identifier><identifier>EISSN: 1724-6075</identifier><identifier>DOI: 10.1177/03915603241240649</identifier><identifier>PMID: 38532550</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><ispartof>Urologia, 2024-08, Vol.91 (3), p.598-603</ispartof><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c292t-14dd3b140400334e770d6eb7c990b541eff92922f53c7e87827087f0eb8b9f3c3</cites><orcidid>0000-0003-1918-5132 ; 0000-0003-0962-0604</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/03915603241240649$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/03915603241240649$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21799,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38532550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GamalEl Din, Sameh Fayek</creatorcontrib><creatorcontrib>Nabil Ismail, Nashaat</creatorcontrib><creatorcontrib>Moawad, Hanan Hosni</creatorcontrib><creatorcontrib>Adel, Iten Mohamed</creatorcontrib><creatorcontrib>Motawi, Ahmad</creatorcontrib><creatorcontrib>Foaad, Hisham</creatorcontrib><title>Evaluation of tadalafil supplementation on the neutrophil/lymphocyte and the platelet/lymphocyte ratios in patients with erectile dysfunction: A prospective study</title><title>Urologia</title><addtitle>Urologia</addtitle><description>Objectives:
We aimed to evaluate the effect of daily 5 mg tadalafil on the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) in patients with erectile dysfunction (ED).
Patients and methods:
30 subjects with ED were given tadalafil as well as 30 subjects with ED who were not receiving tadalafil were recruited. 30 healthy individuals served as controls.
Results:
Receiver operating characteristic curve (ROC) showed that the best cut off point of pre-treatment and post treatment NLR in the ED treatment group was found <1.51, <1.51, sensitivity of 68.3%, 58.3%, specificity of 53.3%, 53.3%, lower bound of 0.558, 0.517, upper bound of 0.789, 0.757, total accuracy of 67.4%, 63.7% and p 0.003, 0.0025, respectively. Additionally, the best cut off point of pre-treatment and post treatment PLR in the ED treatment group was found <5.89, <5.99, sensitivity of 65%, 63.3%, specificity of 63.3%, 53.3%, lower bound of 0.515, 0.435, upper bound of 0.755, 0.687, total accuracy of 63.5%, 56.1% and p 0.027, 0.341, respectively.
Conclusion:
Daily 5 mg Tadalafil supplementation significantly improves erectile function through decreasing these markers as well as depression and anxiety.</description><issn>0391-5603</issn><issn>1724-6075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kN9KwzAYxYMobsw9gDeSF-iWf21a78aYf0DwRq9L2n6xHWkbmnTS1_FJbd0UQTA3X-B3zkm-g9A1JStKpVwTntAwIpwJygSJRHKG5lQyEUREhudoPvFgEszQ0rk9GU9EmGD8Es14HHIWhmSOPnYHZXrlq7bBrcZeFcooXRnsemsN1ND4E2ywLwE30PuutWVl1maobdnmgwesmuKLWqM8GPC_WTf5Ha4abMfbmOfwe-VLDB3kvjKAi8HpvsmnV27xBtuudXZCB8DO98VwhS60Mg6Wp7lAr3e7l-1D8PR8_7jdPAU5S5gPqCgKnlFBBCGcC5CSFBFkMk8SkoWCgtbJKGQ65LmEWMZMklhqAlmcJZrnfIHoMTcff-A60Kntqlp1Q0pJOlWe_ql89NwcPbbPaih-HN8Fj4LVUeDUG6T7tu-acYd_Ej8BjQ-NgA</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>GamalEl Din, Sameh Fayek</creator><creator>Nabil Ismail, Nashaat</creator><creator>Moawad, Hanan Hosni</creator><creator>Adel, Iten Mohamed</creator><creator>Motawi, Ahmad</creator><creator>Foaad, Hisham</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-1918-5132</orcidid><orcidid>https://orcid.org/0000-0003-0962-0604</orcidid></search><sort><creationdate>20240801</creationdate><title>Evaluation of tadalafil supplementation on the neutrophil/lymphocyte and the platelet/lymphocyte ratios in patients with erectile dysfunction: A prospective study</title><author>GamalEl Din, Sameh Fayek ; Nabil Ismail, Nashaat ; Moawad, Hanan Hosni ; Adel, Iten Mohamed ; Motawi, Ahmad ; Foaad, Hisham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-14dd3b140400334e770d6eb7c990b541eff92922f53c7e87827087f0eb8b9f3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GamalEl Din, Sameh Fayek</creatorcontrib><creatorcontrib>Nabil Ismail, Nashaat</creatorcontrib><creatorcontrib>Moawad, Hanan Hosni</creatorcontrib><creatorcontrib>Adel, Iten Mohamed</creatorcontrib><creatorcontrib>Motawi, Ahmad</creatorcontrib><creatorcontrib>Foaad, Hisham</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Urologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GamalEl Din, Sameh Fayek</au><au>Nabil Ismail, Nashaat</au><au>Moawad, Hanan Hosni</au><au>Adel, Iten Mohamed</au><au>Motawi, Ahmad</au><au>Foaad, Hisham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of tadalafil supplementation on the neutrophil/lymphocyte and the platelet/lymphocyte ratios in patients with erectile dysfunction: A prospective study</atitle><jtitle>Urologia</jtitle><addtitle>Urologia</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>91</volume><issue>3</issue><spage>598</spage><epage>603</epage><pages>598-603</pages><issn>0391-5603</issn><eissn>1724-6075</eissn><abstract>Objectives:
We aimed to evaluate the effect of daily 5 mg tadalafil on the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR) in patients with erectile dysfunction (ED).
Patients and methods:
30 subjects with ED were given tadalafil as well as 30 subjects with ED who were not receiving tadalafil were recruited. 30 healthy individuals served as controls.
Results:
Receiver operating characteristic curve (ROC) showed that the best cut off point of pre-treatment and post treatment NLR in the ED treatment group was found <1.51, <1.51, sensitivity of 68.3%, 58.3%, specificity of 53.3%, 53.3%, lower bound of 0.558, 0.517, upper bound of 0.789, 0.757, total accuracy of 67.4%, 63.7% and p 0.003, 0.0025, respectively. Additionally, the best cut off point of pre-treatment and post treatment PLR in the ED treatment group was found <5.89, <5.99, sensitivity of 65%, 63.3%, specificity of 63.3%, 53.3%, lower bound of 0.515, 0.435, upper bound of 0.755, 0.687, total accuracy of 63.5%, 56.1% and p 0.027, 0.341, respectively.
Conclusion:
Daily 5 mg Tadalafil supplementation significantly improves erectile function through decreasing these markers as well as depression and anxiety.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>38532550</pmid><doi>10.1177/03915603241240649</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1918-5132</orcidid><orcidid>https://orcid.org/0000-0003-0962-0604</orcidid></addata></record> |
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| ispartof | Urologia, 2024-08, Vol.91 (3), p.598-603 |
| issn | 0391-5603 1724-6075 |
| language | eng |
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| source | SAGE Publications |
| title | Evaluation of tadalafil supplementation on the neutrophil/lymphocyte and the platelet/lymphocyte ratios in patients with erectile dysfunction: A prospective study |
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