Comparison of histopathological features, survival, and oncological outcome between patients under and above 55-year-old with prostate cancer who underwent radical prostatectomy
Background: To compare the disease course, histopathological features and survival rates of prostate cancer (PCa) between patients aged ⩽ 55 and > 55 year old. Materials and methods: In this retrospective study, we enrolled 644 patients with organ-confide prostate cancer who had undergone radical...
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| Veröffentlicht in: | Urologia 2023-02, Vol.90 (1), p.83-88 |
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| creator | Soltani, Mohammad Hossein Khabazian, Reza Dadpour, Mehdi Borumandnia, Nasrin Simforoosh, Nasser |
| description | Background:
To compare the disease course, histopathological features and survival rates of prostate cancer (PCa) between patients aged ⩽ 55 and > 55 year old.
Materials and methods:
In this retrospective study, we enrolled 644 patients with organ-confide prostate cancer who had undergone radical prostatectomy from 2005 to 2018. Seventy-six (11.8%) patients were under 55 years of age (group 1) and 568 (88.2%) patients were >55 years old (group 2).
Results:
Pre-operative hypertension was detected in 4 (5.3%) patients of group 1 and 80 (14.1%) patients of groups 2 (p = 0.029). The mean (±SD) prostate volume was higher in group 2 compared with group 1 (34.1(±8.4) ml vs 54.1(±9.9) ml, p |
| doi_str_mv | 10.1177/03915603221078266 |
| format | Article |
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To compare the disease course, histopathological features and survival rates of prostate cancer (PCa) between patients aged ⩽ 55 and > 55 year old.
Materials and methods:
In this retrospective study, we enrolled 644 patients with organ-confide prostate cancer who had undergone radical prostatectomy from 2005 to 2018. Seventy-six (11.8%) patients were under 55 years of age (group 1) and 568 (88.2%) patients were >55 years old (group 2).
Results:
Pre-operative hypertension was detected in 4 (5.3%) patients of group 1 and 80 (14.1%) patients of groups 2 (p = 0.029). The mean (±SD) prostate volume was higher in group 2 compared with group 1 (34.1(±8.4) ml vs 54.1(±9.9) ml, p < 0.001). Positive surgery margin was observed in 15 (19.7%) and 58 (10.2%) patients in group 1 and 2, respectively (p = 0.020). Co-existence of diabetes mellitus, mean pre-operative PSA, Gleason’s score, and permanent pathology and pathologic stage were similar between the two groups. Log-rank test failed to show any statistical difference in terms of biochemical-relapse free survival, local recurrence-free survival, and metastasis-free survival between the two groups (p = 0.316, 0.441, 0.654, respectively). After performing multivariate analysis, positive surgical margin was the only factor that was independently predictive of biochemical relapse (p < 0.001) and local recurrence/metastasis (p < 0.001).
Conclusion:
No difference was observed in terms of histopathologic features, biochemical relapse, and local recurrence/metastasis-free survival rates between patients younger and older than 55 years of age.</description><identifier>ISSN: 0391-5603</identifier><identifier>EISSN: 1724-6075</identifier><identifier>DOI: 10.1177/03915603221078266</identifier><identifier>PMID: 35191332</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Disease-Free Survival ; Humans ; Male ; Margins of Excision ; Middle Aged ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Prostate - pathology ; Prostate-Specific Antigen ; Prostatectomy - adverse effects ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Retrospective Studies</subject><ispartof>Urologia, 2023-02, Vol.90 (1), p.83-88</ispartof><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c292t-238935f3740ddcc3c5c651c410b58c3920d6989c978ef8d15369359a1b9b99803</cites><orcidid>0000-0003-3550-3778</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/03915603221078266$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/03915603221078266$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35191332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soltani, Mohammad Hossein</creatorcontrib><creatorcontrib>Khabazian, Reza</creatorcontrib><creatorcontrib>Dadpour, Mehdi</creatorcontrib><creatorcontrib>Borumandnia, Nasrin</creatorcontrib><creatorcontrib>Simforoosh, Nasser</creatorcontrib><title>Comparison of histopathological features, survival, and oncological outcome between patients under and above 55-year-old with prostate cancer who underwent radical prostatectomy</title><title>Urologia</title><addtitle>Urologia</addtitle><description>Background:
To compare the disease course, histopathological features and survival rates of prostate cancer (PCa) between patients aged ⩽ 55 and > 55 year old.
Materials and methods:
In this retrospective study, we enrolled 644 patients with organ-confide prostate cancer who had undergone radical prostatectomy from 2005 to 2018. Seventy-six (11.8%) patients were under 55 years of age (group 1) and 568 (88.2%) patients were >55 years old (group 2).
Results:
Pre-operative hypertension was detected in 4 (5.3%) patients of group 1 and 80 (14.1%) patients of groups 2 (p = 0.029). The mean (±SD) prostate volume was higher in group 2 compared with group 1 (34.1(±8.4) ml vs 54.1(±9.9) ml, p < 0.001). Positive surgery margin was observed in 15 (19.7%) and 58 (10.2%) patients in group 1 and 2, respectively (p = 0.020). Co-existence of diabetes mellitus, mean pre-operative PSA, Gleason’s score, and permanent pathology and pathologic stage were similar between the two groups. Log-rank test failed to show any statistical difference in terms of biochemical-relapse free survival, local recurrence-free survival, and metastasis-free survival between the two groups (p = 0.316, 0.441, 0.654, respectively). After performing multivariate analysis, positive surgical margin was the only factor that was independently predictive of biochemical relapse (p < 0.001) and local recurrence/metastasis (p < 0.001).
Conclusion:
No difference was observed in terms of histopathologic features, biochemical relapse, and local recurrence/metastasis-free survival rates between patients younger and older than 55 years of age.</description><subject>Aged</subject><subject>Disease-Free Survival</subject><subject>Humans</subject><subject>Male</subject><subject>Margins of Excision</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Prostate - pathology</subject><subject>Prostate-Specific Antigen</subject><subject>Prostatectomy - adverse effects</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Retrospective Studies</subject><issn>0391-5603</issn><issn>1724-6075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtuwyAURVHVqonSLKCTigXEKR9jm2EV9SdF6qQdWxhw7Mg2FuBEWVZ3WBI3mVTqmzB451wEF4B7jJYYp-kjohyzBFFCMEozkiRXYIpTEkcJStk1mB730RGYgLlzWxQmQSQm9BZMKMMcU0qm4Htl2l7Y2pkOmhJWtfOmF74yjdnUUjSw1MIPVrsFdIPd1TvRLKDoFDSdvDBm8NK0Ghba77XuYAiodecdHDql7QkXhdlpyFh00MJGplFwX_sK9tY4L7yGUnQyoPvKjNI--NAKdco_U9Kb9nAHbkrROD3_PWfg6-X5c_UWrT9e31dP60gSTnxEaMYpK2kaI6WkpJLJhGEZY1SwTFJOkEp4xiVPM11mCjOaBJ4LXPCC8wzRGcBjrgy3O6vLvLd1K-whxyg_NpD_aSA4D6PTD0Wr1cU4_3cAliPgxEbnWzPYLrzhn8QfCHuRxQ</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Soltani, Mohammad Hossein</creator><creator>Khabazian, Reza</creator><creator>Dadpour, Mehdi</creator><creator>Borumandnia, Nasrin</creator><creator>Simforoosh, Nasser</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-3550-3778</orcidid></search><sort><creationdate>202302</creationdate><title>Comparison of histopathological features, survival, and oncological outcome between patients under and above 55-year-old with prostate cancer who underwent radical prostatectomy</title><author>Soltani, Mohammad Hossein ; Khabazian, Reza ; Dadpour, Mehdi ; Borumandnia, Nasrin ; Simforoosh, Nasser</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-238935f3740ddcc3c5c651c410b58c3920d6989c978ef8d15369359a1b9b99803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Disease-Free Survival</topic><topic>Humans</topic><topic>Male</topic><topic>Margins of Excision</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Prostate - pathology</topic><topic>Prostate-Specific Antigen</topic><topic>Prostatectomy - adverse effects</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soltani, Mohammad Hossein</creatorcontrib><creatorcontrib>Khabazian, Reza</creatorcontrib><creatorcontrib>Dadpour, Mehdi</creatorcontrib><creatorcontrib>Borumandnia, Nasrin</creatorcontrib><creatorcontrib>Simforoosh, Nasser</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Urologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soltani, Mohammad Hossein</au><au>Khabazian, Reza</au><au>Dadpour, Mehdi</au><au>Borumandnia, Nasrin</au><au>Simforoosh, Nasser</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of histopathological features, survival, and oncological outcome between patients under and above 55-year-old with prostate cancer who underwent radical prostatectomy</atitle><jtitle>Urologia</jtitle><addtitle>Urologia</addtitle><date>2023-02</date><risdate>2023</risdate><volume>90</volume><issue>1</issue><spage>83</spage><epage>88</epage><pages>83-88</pages><issn>0391-5603</issn><eissn>1724-6075</eissn><abstract>Background:
To compare the disease course, histopathological features and survival rates of prostate cancer (PCa) between patients aged ⩽ 55 and > 55 year old.
Materials and methods:
In this retrospective study, we enrolled 644 patients with organ-confide prostate cancer who had undergone radical prostatectomy from 2005 to 2018. Seventy-six (11.8%) patients were under 55 years of age (group 1) and 568 (88.2%) patients were >55 years old (group 2).
Results:
Pre-operative hypertension was detected in 4 (5.3%) patients of group 1 and 80 (14.1%) patients of groups 2 (p = 0.029). The mean (±SD) prostate volume was higher in group 2 compared with group 1 (34.1(±8.4) ml vs 54.1(±9.9) ml, p < 0.001). Positive surgery margin was observed in 15 (19.7%) and 58 (10.2%) patients in group 1 and 2, respectively (p = 0.020). Co-existence of diabetes mellitus, mean pre-operative PSA, Gleason’s score, and permanent pathology and pathologic stage were similar between the two groups. Log-rank test failed to show any statistical difference in terms of biochemical-relapse free survival, local recurrence-free survival, and metastasis-free survival between the two groups (p = 0.316, 0.441, 0.654, respectively). After performing multivariate analysis, positive surgical margin was the only factor that was independently predictive of biochemical relapse (p < 0.001) and local recurrence/metastasis (p < 0.001).
Conclusion:
No difference was observed in terms of histopathologic features, biochemical relapse, and local recurrence/metastasis-free survival rates between patients younger and older than 55 years of age.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>35191332</pmid><doi>10.1177/03915603221078266</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3550-3778</orcidid></addata></record> |
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| subjects | Aged Disease-Free Survival Humans Male Margins of Excision Middle Aged Neoplasm Recurrence, Local - pathology Neoplasm Staging Prostate - pathology Prostate-Specific Antigen Prostatectomy - adverse effects Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Retrospective Studies |
| title | Comparison of histopathological features, survival, and oncological outcome between patients under and above 55-year-old with prostate cancer who underwent radical prostatectomy |
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