Cytochemical detection of inherited copper toxicosis of Bedlington Terriers [Dogs]
Sections of paraffin-embedded specimens of liver obtained from Bedlington terriers were stained with rhodanine for copper and examined and graded by two pathologists. Their results correlated well with each other, as well as with the results of quantitative determinations of hepatic copper content....
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| Veröffentlicht in: | Veterinary pathology 1984-01, Vol.21 (1), p.57-60 |
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| container_title | Veterinary pathology |
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| creator | Johnson, G.F Gilbertson, S.R Goldfischer, S Grushoff, P.S Sternlieb, I |
| description | Sections of paraffin-embedded specimens of liver obtained from Bedlington terriers were stained with rhodanine for copper and examined and graded by two pathologists. Their results correlated well with each other, as well as with the results of quantitative determinations of hepatic copper content. Copper toxicosis was established by cytochemistry in 20 of 21 specimens, indicating a sensitivity of 95%. The method is highly specific—none of the 19 specimens obtained from unaffected dogs displayed copper-containing granules suggestive of copper toxicosis. Copper cytochemistry appears to be a satisfactory substitute for chemical analysis of hepatic copper content. |
| doi_str_mv | 10.1177/030098588402100110 |
| format | Article |
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Their results correlated well with each other, as well as with the results of quantitative determinations of hepatic copper content. Copper toxicosis was established by cytochemistry in 20 of 21 specimens, indicating a sensitivity of 95%. The method is highly specific—none of the 19 specimens obtained from unaffected dogs displayed copper-containing granules suggestive of copper toxicosis. Copper cytochemistry appears to be a satisfactory substitute for chemical analysis of hepatic copper content.</description><identifier>ISSN: 0300-9858</identifier><identifier>EISSN: 1544-2217</identifier><identifier>DOI: 10.1177/030098588402100110</identifier><identifier>PMID: 6710813</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Age Factors ; Animals ; Copper - metabolism ; Cytoplasmic Granules - analysis ; Dog Diseases - diagnosis ; Dog Diseases - genetics ; Dog Diseases - metabolism ; Dogs ; Female ; Histocytochemistry ; Liver - metabolism ; Liver - pathology ; Liver - ultrastructure ; Male ; Metal Metabolism, Inborn Errors - diagnosis ; Metal Metabolism, Inborn Errors - genetics ; Metal Metabolism, Inborn Errors - metabolism ; Metal Metabolism, Inborn Errors - veterinary ; Rhodanine</subject><ispartof>Veterinary pathology, 1984-01, Vol.21 (1), p.57-60</ispartof><rights>1984 American College of Veterinary Pathologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d5c840bf67a9e23d97b2b71eaad4c0c7b32530b8eb2f4b01d6363bf782e9cf2b3</citedby><cites>FETCH-LOGICAL-c357t-d5c840bf67a9e23d97b2b71eaad4c0c7b32530b8eb2f4b01d6363bf782e9cf2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/030098588402100110$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/030098588402100110$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6710813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, G.F</creatorcontrib><creatorcontrib>Gilbertson, S.R</creatorcontrib><creatorcontrib>Goldfischer, S</creatorcontrib><creatorcontrib>Grushoff, P.S</creatorcontrib><creatorcontrib>Sternlieb, I</creatorcontrib><title>Cytochemical detection of inherited copper toxicosis of Bedlington Terriers [Dogs]</title><title>Veterinary pathology</title><addtitle>Vet Pathol</addtitle><description>Sections of paraffin-embedded specimens of liver obtained from Bedlington terriers were stained with rhodanine for copper and examined and graded by two pathologists. Their results correlated well with each other, as well as with the results of quantitative determinations of hepatic copper content. Copper toxicosis was established by cytochemistry in 20 of 21 specimens, indicating a sensitivity of 95%. The method is highly specific—none of the 19 specimens obtained from unaffected dogs displayed copper-containing granules suggestive of copper toxicosis. Copper cytochemistry appears to be a satisfactory substitute for chemical analysis of hepatic copper content.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Copper - metabolism</subject><subject>Cytoplasmic Granules - analysis</subject><subject>Dog Diseases - diagnosis</subject><subject>Dog Diseases - genetics</subject><subject>Dog Diseases - metabolism</subject><subject>Dogs</subject><subject>Female</subject><subject>Histocytochemistry</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver - ultrastructure</subject><subject>Male</subject><subject>Metal Metabolism, Inborn Errors - diagnosis</subject><subject>Metal Metabolism, Inborn Errors - genetics</subject><subject>Metal Metabolism, Inborn Errors - metabolism</subject><subject>Metal Metabolism, Inborn Errors - veterinary</subject><subject>Rhodanine</subject><issn>0300-9858</issn><issn>1544-2217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AUhQdRaq3-gYKQPxA7jyQzWWp9QkHQdiUS5nEnndJ2wkwK9t-bEHEjuLqLc77DuQehKcE3hHA-wwzjUuRCZJgSjAnBJ2hM8ixLKSX8FI17Q9o7ztFFjBuMKS0FH6FRwQkWhI3R2_zYer2GndNymxhoQbfO7xNvE7dfQ3AtmET7poGQtP7LaR9d7NU7MFu3r9vOu4QQHISYfNz7On5eojMrtxGufu4ErR4flvPndPH69DK_XaSa5bxNTa673soWXJZAmSm5oooTkNJkGmuuGM0ZVgIUtZnCxBSsYMpyQaHUlio2QXTI1cHHGMBWTXA7GY4VwVW_T_V3nw66HqDmoHZgfpGfQTp9NuhR1lBt_CHsux_-T5wOhJW-knVwsVq9i6wQeUbZNyrrdsU</recordid><startdate>198401</startdate><enddate>198401</enddate><creator>Johnson, G.F</creator><creator>Gilbertson, S.R</creator><creator>Goldfischer, S</creator><creator>Grushoff, P.S</creator><creator>Sternlieb, I</creator><general>SAGE Publications</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198401</creationdate><title>Cytochemical detection of inherited copper toxicosis of Bedlington Terriers [Dogs]</title><author>Johnson, G.F ; Gilbertson, S.R ; Goldfischer, S ; Grushoff, P.S ; Sternlieb, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d5c840bf67a9e23d97b2b71eaad4c0c7b32530b8eb2f4b01d6363bf782e9cf2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Copper - metabolism</topic><topic>Cytoplasmic Granules - analysis</topic><topic>Dog Diseases - diagnosis</topic><topic>Dog Diseases - genetics</topic><topic>Dog Diseases - metabolism</topic><topic>Dogs</topic><topic>Female</topic><topic>Histocytochemistry</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver - ultrastructure</topic><topic>Male</topic><topic>Metal Metabolism, Inborn Errors - diagnosis</topic><topic>Metal Metabolism, Inborn Errors - genetics</topic><topic>Metal Metabolism, Inborn Errors - metabolism</topic><topic>Metal Metabolism, Inborn Errors - veterinary</topic><topic>Rhodanine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, G.F</creatorcontrib><creatorcontrib>Gilbertson, S.R</creatorcontrib><creatorcontrib>Goldfischer, S</creatorcontrib><creatorcontrib>Grushoff, P.S</creatorcontrib><creatorcontrib>Sternlieb, I</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Veterinary pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, G.F</au><au>Gilbertson, S.R</au><au>Goldfischer, S</au><au>Grushoff, P.S</au><au>Sternlieb, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytochemical detection of inherited copper toxicosis of Bedlington Terriers [Dogs]</atitle><jtitle>Veterinary pathology</jtitle><addtitle>Vet Pathol</addtitle><date>1984-01</date><risdate>1984</risdate><volume>21</volume><issue>1</issue><spage>57</spage><epage>60</epage><pages>57-60</pages><issn>0300-9858</issn><eissn>1544-2217</eissn><abstract>Sections of paraffin-embedded specimens of liver obtained from Bedlington terriers were stained with rhodanine for copper and examined and graded by two pathologists. Their results correlated well with each other, as well as with the results of quantitative determinations of hepatic copper content. Copper toxicosis was established by cytochemistry in 20 of 21 specimens, indicating a sensitivity of 95%. The method is highly specific—none of the 19 specimens obtained from unaffected dogs displayed copper-containing granules suggestive of copper toxicosis. Copper cytochemistry appears to be a satisfactory substitute for chemical analysis of hepatic copper content.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>6710813</pmid><doi>10.1177/030098588402100110</doi><tpages>4</tpages></addata></record> |
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| ispartof | Veterinary pathology, 1984-01, Vol.21 (1), p.57-60 |
| issn | 0300-9858 1544-2217 |
| language | eng |
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| source | Access via SAGE; MEDLINE |
| subjects | Age Factors Animals Copper - metabolism Cytoplasmic Granules - analysis Dog Diseases - diagnosis Dog Diseases - genetics Dog Diseases - metabolism Dogs Female Histocytochemistry Liver - metabolism Liver - pathology Liver - ultrastructure Male Metal Metabolism, Inborn Errors - diagnosis Metal Metabolism, Inborn Errors - genetics Metal Metabolism, Inborn Errors - metabolism Metal Metabolism, Inborn Errors - veterinary Rhodanine |
| title | Cytochemical detection of inherited copper toxicosis of Bedlington Terriers [Dogs] |
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