Adjuvant chemotherapy and whole abdominal irradiation for gastric carcinoma
To analyze the efficacy and toxicity of adjuvant chemotherapy followed by whole abdominal irradiation in the treatment of resectable gastric cancer with positive lymph nodes. Between 1996 and 1999, 10 patients with node-positive gastric cancer underwent complete gross resection and were treated by p...
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| Veröffentlicht in: | Tumori 2008-07, Vol.94 (4), p.469-473 |
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| creator | Kundel, Yulia Levitt, Mark L Oberman, Bernice Sadezki, Siegal Tichler, Thomas Symon, Zvi Catane, Raphael Pfeffer, Raphael Brenner, Baruch |
| description | To analyze the efficacy and toxicity of adjuvant chemotherapy followed by whole abdominal irradiation in the treatment of resectable gastric cancer with positive lymph nodes.
Between 1996 and 1999, 10 patients with node-positive gastric cancer underwent complete gross resection and were treated by postoperative chemoradiotherapy. The chemotherapy regimen consisted of 5-fluorouracil, 1000 mg/m2/day as a 96-hr continuous infusion on day 1, and cisplatin, 100 mg/m2 on day 2, every 21 days. Six courses were planned. Radiotherapy was administered 3 weeks after completion of the chemotherapy protocol as a single-fraction dose of 600 cGy in a two-field (anterior and posterior) configuration.
Treatment was generally well tolerated, with no treatment-related deaths. However, 9 of the 10 patients died of recurrent disease, with a median survival of 20 months (range, 7-84).
Adjuvant chemotherapy with whole abdominal irradiation for gastric cancer is safe and tolerable but has no apparent effect on patient outcome. Studies in larger series are needed to evaluate the role of the approach in this disease. |
| doi_str_mv | 10.1177/030089160809400405 |
| format | Article |
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Between 1996 and 1999, 10 patients with node-positive gastric cancer underwent complete gross resection and were treated by postoperative chemoradiotherapy. The chemotherapy regimen consisted of 5-fluorouracil, 1000 mg/m2/day as a 96-hr continuous infusion on day 1, and cisplatin, 100 mg/m2 on day 2, every 21 days. Six courses were planned. Radiotherapy was administered 3 weeks after completion of the chemotherapy protocol as a single-fraction dose of 600 cGy in a two-field (anterior and posterior) configuration.
Treatment was generally well tolerated, with no treatment-related deaths. However, 9 of the 10 patients died of recurrent disease, with a median survival of 20 months (range, 7-84).
Adjuvant chemotherapy with whole abdominal irradiation for gastric cancer is safe and tolerable but has no apparent effect on patient outcome. Studies in larger series are needed to evaluate the role of the approach in this disease.</description><identifier>ISSN: 0300-8916</identifier><identifier>EISSN: 2038-2529</identifier><identifier>DOI: 10.1177/030089160809400405</identifier><identifier>PMID: 18822680</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Carcinoma - drug therapy ; Carcinoma - pathology ; Carcinoma - radiotherapy ; Carcinoma - surgery ; Chemotherapy, Adjuvant ; Cisplatin - administration & dosage ; Dose Fractionation ; Female ; Fluorouracil - administration & dosage ; Humans ; Infusions, Intravenous ; Lymphatic Metastasis ; Male ; Middle Aged ; Radiotherapy, Adjuvant ; Retrospective Studies ; Stomach Neoplasms - drug therapy ; Stomach Neoplasms - pathology ; Stomach Neoplasms - radiotherapy ; Stomach Neoplasms - surgery ; Survival Analysis ; Treatment Outcome</subject><ispartof>Tumori, 2008-07, Vol.94 (4), p.469-473</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-13777692cd4b82ffc12de03b1da1f6959afe8e6a1330add29b66aa9883ee4d63</citedby><cites>FETCH-LOGICAL-c367t-13777692cd4b82ffc12de03b1da1f6959afe8e6a1330add29b66aa9883ee4d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18822680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kundel, Yulia</creatorcontrib><creatorcontrib>Levitt, Mark L</creatorcontrib><creatorcontrib>Oberman, Bernice</creatorcontrib><creatorcontrib>Sadezki, Siegal</creatorcontrib><creatorcontrib>Tichler, Thomas</creatorcontrib><creatorcontrib>Symon, Zvi</creatorcontrib><creatorcontrib>Catane, Raphael</creatorcontrib><creatorcontrib>Pfeffer, Raphael</creatorcontrib><creatorcontrib>Brenner, Baruch</creatorcontrib><title>Adjuvant chemotherapy and whole abdominal irradiation for gastric carcinoma</title><title>Tumori</title><addtitle>Tumori</addtitle><description>To analyze the efficacy and toxicity of adjuvant chemotherapy followed by whole abdominal irradiation in the treatment of resectable gastric cancer with positive lymph nodes.
Between 1996 and 1999, 10 patients with node-positive gastric cancer underwent complete gross resection and were treated by postoperative chemoradiotherapy. The chemotherapy regimen consisted of 5-fluorouracil, 1000 mg/m2/day as a 96-hr continuous infusion on day 1, and cisplatin, 100 mg/m2 on day 2, every 21 days. Six courses were planned. Radiotherapy was administered 3 weeks after completion of the chemotherapy protocol as a single-fraction dose of 600 cGy in a two-field (anterior and posterior) configuration.
Treatment was generally well tolerated, with no treatment-related deaths. However, 9 of the 10 patients died of recurrent disease, with a median survival of 20 months (range, 7-84).
Adjuvant chemotherapy with whole abdominal irradiation for gastric cancer is safe and tolerable but has no apparent effect on patient outcome. Studies in larger series are needed to evaluate the role of the approach in this disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Carcinoma - drug therapy</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - radiotherapy</subject><subject>Carcinoma - surgery</subject><subject>Chemotherapy, Adjuvant</subject><subject>Cisplatin - administration & dosage</subject><subject>Dose Fractionation</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Stomach Neoplasms - drug therapy</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - radiotherapy</subject><subject>Stomach Neoplasms - surgery</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><issn>0300-8916</issn><issn>2038-2529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkL1OwzAURi0EoqXwAgzILxC4thPHHqsKCqISS_foxj_EVRJXTgrq20PUSgxM33LONxxC7hk8MlaWTyAAlGYSFOgcIIfigsw5CJXxgutLMp-AbCJm5GYYdhPCpbwmM6YU51LBnLwv7e7whf1ITeO6ODYu4f5Isbf0u4mto1jb2IUeWxpSQhtwDLGnPib6icOYgqEGkwl97PCWXHlsB3d33gXZvjxvV6_Z5mP9tlpuMiNkOWZMlGUpNTc2rxX33jBuHYiaWWRe6kKjd8pJZEIAWst1LSWiVko4l1spFoSfbk2Kw5Ccr_YpdJiOFYNqClP9D_MrPZyk_aHunP1TziXED9gsXuM</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Kundel, Yulia</creator><creator>Levitt, Mark L</creator><creator>Oberman, Bernice</creator><creator>Sadezki, Siegal</creator><creator>Tichler, Thomas</creator><creator>Symon, Zvi</creator><creator>Catane, Raphael</creator><creator>Pfeffer, Raphael</creator><creator>Brenner, Baruch</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20080701</creationdate><title>Adjuvant chemotherapy and whole abdominal irradiation for gastric carcinoma</title><author>Kundel, Yulia ; 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Between 1996 and 1999, 10 patients with node-positive gastric cancer underwent complete gross resection and were treated by postoperative chemoradiotherapy. The chemotherapy regimen consisted of 5-fluorouracil, 1000 mg/m2/day as a 96-hr continuous infusion on day 1, and cisplatin, 100 mg/m2 on day 2, every 21 days. Six courses were planned. Radiotherapy was administered 3 weeks after completion of the chemotherapy protocol as a single-fraction dose of 600 cGy in a two-field (anterior and posterior) configuration.
Treatment was generally well tolerated, with no treatment-related deaths. However, 9 of the 10 patients died of recurrent disease, with a median survival of 20 months (range, 7-84).
Adjuvant chemotherapy with whole abdominal irradiation for gastric cancer is safe and tolerable but has no apparent effect on patient outcome. Studies in larger series are needed to evaluate the role of the approach in this disease.</abstract><cop>United States</cop><pmid>18822680</pmid><doi>10.1177/030089160809400405</doi><tpages>5</tpages></addata></record> |
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| ispartof | Tumori, 2008-07, Vol.94 (4), p.469-473 |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma - drug therapy Carcinoma - pathology Carcinoma - radiotherapy Carcinoma - surgery Chemotherapy, Adjuvant Cisplatin - administration & dosage Dose Fractionation Female Fluorouracil - administration & dosage Humans Infusions, Intravenous Lymphatic Metastasis Male Middle Aged Radiotherapy, Adjuvant Retrospective Studies Stomach Neoplasms - drug therapy Stomach Neoplasms - pathology Stomach Neoplasms - radiotherapy Stomach Neoplasms - surgery Survival Analysis Treatment Outcome |
| title | Adjuvant chemotherapy and whole abdominal irradiation for gastric carcinoma |
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