Clinicopathological features of isolated pulmonary cryptococcosis in HIV-negative patients
Objective To analyse the clinicopathological features of isolated pulmonary cryptococcosis in human immunodeficiency virus (HIV)-negative patients. Methods This retrospective study analysed the following data from HIV-negative patients diagnosed with pulmonary cryptococcosis: demographics, underlyin...
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| Veröffentlicht in: | Journal of international medical research 2020-06, Vol.48 (6), p.300060520927877-300060520927877 |
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| creator | Wu, Huan-Huan Chen, Yan-Xiao Fang, Shuang-Yan |
| description | Objective
To analyse the clinicopathological features of isolated pulmonary cryptococcosis in human immunodeficiency virus (HIV)-negative patients.
Methods
This retrospective study analysed the following data from HIV-negative patients diagnosed with pulmonary cryptococcosis: demographics, underlying diseases, clinical manifestations on admission, laboratory tests, imaging data, results of histopathology, treatment options and outcomes. Sputum samples from all patients were collected and assessed for the presence of yeast or fungi. Cryptococcal antigen testing was performed for some patients. Histopathological analysis was also undertaken for some samples of lung tissue.
Results
The study analysed 37 patients (22 males). Thirteen (35.14%) patients were asymptomatic, 24 (64.86%) were symptomatic and 17 (45.95%) patients had no underlying disease. Out of 25 tested patients, 23 (92.00%) tested positive on the serum cryptococcal capsular polysaccharide antigen test. During 6 to 24 months of follow-up, all 37 patients that were either treated with or without antifungal therapy alone or combined with surgical resection showed complete recovery. One patient made a full recovery without any treatment.
Conclusion
Early identification of pulmonary cryptococcosis in HIV-negative patients and timely detection of cryptococcal antigens in serum or respiratory specimens may help to improve diagnosis, prognosis and treatment of the disease. |
| doi_str_mv | 10.1177/0300060520927877 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_crossref_primary_10_1177_0300060520927877</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0300060520927877</sage_id><doaj_id>oai_doaj_org_article_9da3db4499eb4e34a838bb9a969b7da4</doaj_id><sourcerecordid>2412991330</sourcerecordid><originalsourceid>FETCH-LOGICAL-c528t-eb63c0a8fb84b16bf2a3e538c8369c8f178db61b71bcb74910e7a05911626e913</originalsourceid><addsrcrecordid>eNp1ks1v1DAQxS0EokvhzglF4sIl4K_E9gUJrYCuVIkLcOBijZ1J6lU2XuykUv97HLYUWomTpZk3P79nDyEvGX3LmFLvqKCUtrTh1HCllXpENkwqUfNSf0w2a7te-2fkWc57SiVvG_6UnAnecMUp35Af2zFMwccjzFdxjEPwMFY9wrwkzFXsq5DjCDN21XEZD3GCdFP5dHOco4_exxxyFabqYve9nnCAOVxjVVABpzk_J096GDO-uD3PybdPH79uL-rLL5932w-XtW-4nmt0rfAUdO-0dKx1PQeBjdBei9Z43TOlO9cyp5jzTknDKCqgjWGs5S0aJs7J7sTtIuztMYVDMWkjBPu7ENNgIc3Bj2hNB6JzUhqDTqKQoIV2zoBpjVMdyMJ6f2IdF3fAzpccCcZ70PudKVzZIV5bxY1s6Ap4cwtI8eeCebaHkD2OI0wYl2y5ZNwU04IW6esH0n1c0lSeqqikEEowvaajJ5VPMeeE_Z0ZRu26BPbhEpSRV_-GuBv48-tFUJ8EGQb8e-t_gb8AUUS6fg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2443373181</pqid></control><display><type>article</type><title>Clinicopathological features of isolated pulmonary cryptococcosis in HIV-negative patients</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>SAGE Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Wu, Huan-Huan ; Chen, Yan-Xiao ; Fang, Shuang-Yan</creator><creatorcontrib>Wu, Huan-Huan ; Chen, Yan-Xiao ; Fang, Shuang-Yan</creatorcontrib><description>Objective
To analyse the clinicopathological features of isolated pulmonary cryptococcosis in human immunodeficiency virus (HIV)-negative patients.
Methods
This retrospective study analysed the following data from HIV-negative patients diagnosed with pulmonary cryptococcosis: demographics, underlying diseases, clinical manifestations on admission, laboratory tests, imaging data, results of histopathology, treatment options and outcomes. Sputum samples from all patients were collected and assessed for the presence of yeast or fungi. Cryptococcal antigen testing was performed for some patients. Histopathological analysis was also undertaken for some samples of lung tissue.
Results
The study analysed 37 patients (22 males). Thirteen (35.14%) patients were asymptomatic, 24 (64.86%) were symptomatic and 17 (45.95%) patients had no underlying disease. Out of 25 tested patients, 23 (92.00%) tested positive on the serum cryptococcal capsular polysaccharide antigen test. During 6 to 24 months of follow-up, all 37 patients that were either treated with or without antifungal therapy alone or combined with surgical resection showed complete recovery. One patient made a full recovery without any treatment.
Conclusion
Early identification of pulmonary cryptococcosis in HIV-negative patients and timely detection of cryptococcal antigens in serum or respiratory specimens may help to improve diagnosis, prognosis and treatment of the disease.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/0300060520927877</identifier><identifier>PMID: 32527202</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antifungal Agents - therapeutic use ; Antigens ; Antigens, Fungal - immunology ; Antigens, Fungal - isolation & purification ; Asymptomatic Infections ; Cryptococcosis - diagnosis ; Cryptococcosis - drug therapy ; Cryptococcosis - immunology ; Cryptococcosis - microbiology ; Cryptococcus - immunology ; Cryptococcus - isolation & purification ; Female ; Follow-Up Studies ; HIV ; Human immunodeficiency virus ; Humans ; Lung - diagnostic imaging ; Lung - immunology ; Lung - microbiology ; Lung Diseases, Fungal - diagnosis ; Lung Diseases, Fungal - drug therapy ; Lung Diseases, Fungal - immunology ; Lung Diseases, Fungal - microbiology ; Male ; Middle Aged ; Polysaccharides - immunology ; Polysaccharides - isolation & purification ; Retrospective Clinical Research Report ; Retrospective Studies ; Sputum - microbiology ; Tomography, X-Ray Computed</subject><ispartof>Journal of international medical research, 2020-06, Vol.48 (6), p.300060520927877-300060520927877</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020 2020 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-eb63c0a8fb84b16bf2a3e538c8369c8f178db61b71bcb74910e7a05911626e913</citedby><cites>FETCH-LOGICAL-c528t-eb63c0a8fb84b16bf2a3e538c8369c8f178db61b71bcb74910e7a05911626e913</cites><orcidid>0000-0001-8324-9570</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294504/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294504/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,21945,27830,27901,27902,44921,45309,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32527202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Huan-Huan</creatorcontrib><creatorcontrib>Chen, Yan-Xiao</creatorcontrib><creatorcontrib>Fang, Shuang-Yan</creatorcontrib><title>Clinicopathological features of isolated pulmonary cryptococcosis in HIV-negative patients</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>Objective
To analyse the clinicopathological features of isolated pulmonary cryptococcosis in human immunodeficiency virus (HIV)-negative patients.
Methods
This retrospective study analysed the following data from HIV-negative patients diagnosed with pulmonary cryptococcosis: demographics, underlying diseases, clinical manifestations on admission, laboratory tests, imaging data, results of histopathology, treatment options and outcomes. Sputum samples from all patients were collected and assessed for the presence of yeast or fungi. Cryptococcal antigen testing was performed for some patients. Histopathological analysis was also undertaken for some samples of lung tissue.
Results
The study analysed 37 patients (22 males). Thirteen (35.14%) patients were asymptomatic, 24 (64.86%) were symptomatic and 17 (45.95%) patients had no underlying disease. Out of 25 tested patients, 23 (92.00%) tested positive on the serum cryptococcal capsular polysaccharide antigen test. During 6 to 24 months of follow-up, all 37 patients that were either treated with or without antifungal therapy alone or combined with surgical resection showed complete recovery. One patient made a full recovery without any treatment.
Conclusion
Early identification of pulmonary cryptococcosis in HIV-negative patients and timely detection of cryptococcal antigens in serum or respiratory specimens may help to improve diagnosis, prognosis and treatment of the disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Antigens</subject><subject>Antigens, Fungal - immunology</subject><subject>Antigens, Fungal - isolation & purification</subject><subject>Asymptomatic Infections</subject><subject>Cryptococcosis - diagnosis</subject><subject>Cryptococcosis - drug therapy</subject><subject>Cryptococcosis - immunology</subject><subject>Cryptococcosis - microbiology</subject><subject>Cryptococcus - immunology</subject><subject>Cryptococcus - isolation & purification</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - immunology</subject><subject>Lung - microbiology</subject><subject>Lung Diseases, Fungal - diagnosis</subject><subject>Lung Diseases, Fungal - drug therapy</subject><subject>Lung Diseases, Fungal - immunology</subject><subject>Lung Diseases, Fungal - microbiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polysaccharides - immunology</subject><subject>Polysaccharides - isolation & purification</subject><subject>Retrospective Clinical Research Report</subject><subject>Retrospective Studies</subject><subject>Sputum - microbiology</subject><subject>Tomography, X-Ray Computed</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp1ks1v1DAQxS0EokvhzglF4sIl4K_E9gUJrYCuVIkLcOBijZ1J6lU2XuykUv97HLYUWomTpZk3P79nDyEvGX3LmFLvqKCUtrTh1HCllXpENkwqUfNSf0w2a7te-2fkWc57SiVvG_6UnAnecMUp35Af2zFMwccjzFdxjEPwMFY9wrwkzFXsq5DjCDN21XEZD3GCdFP5dHOco4_exxxyFabqYve9nnCAOVxjVVABpzk_J096GDO-uD3PybdPH79uL-rLL5932w-XtW-4nmt0rfAUdO-0dKx1PQeBjdBei9Z43TOlO9cyp5jzTknDKCqgjWGs5S0aJs7J7sTtIuztMYVDMWkjBPu7ENNgIc3Bj2hNB6JzUhqDTqKQoIV2zoBpjVMdyMJ6f2IdF3fAzpccCcZ70PudKVzZIV5bxY1s6Ap4cwtI8eeCebaHkD2OI0wYl2y5ZNwU04IW6esH0n1c0lSeqqikEEowvaajJ5VPMeeE_Z0ZRu26BPbhEpSRV_-GuBv48-tFUJ8EGQb8e-t_gb8AUUS6fg</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Wu, Huan-Huan</creator><creator>Chen, Yan-Xiao</creator><creator>Fang, Shuang-Yan</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><general>SAGE Publishing</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8324-9570</orcidid></search><sort><creationdate>20200601</creationdate><title>Clinicopathological features of isolated pulmonary cryptococcosis in HIV-negative patients</title><author>Wu, Huan-Huan ; Chen, Yan-Xiao ; Fang, Shuang-Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-eb63c0a8fb84b16bf2a3e538c8369c8f178db61b71bcb74910e7a05911626e913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Antigens</topic><topic>Antigens, Fungal - immunology</topic><topic>Antigens, Fungal - isolation & purification</topic><topic>Asymptomatic Infections</topic><topic>Cryptococcosis - diagnosis</topic><topic>Cryptococcosis - drug therapy</topic><topic>Cryptococcosis - immunology</topic><topic>Cryptococcosis - microbiology</topic><topic>Cryptococcus - immunology</topic><topic>Cryptococcus - isolation & purification</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - immunology</topic><topic>Lung - microbiology</topic><topic>Lung Diseases, Fungal - diagnosis</topic><topic>Lung Diseases, Fungal - drug therapy</topic><topic>Lung Diseases, Fungal - immunology</topic><topic>Lung Diseases, Fungal - microbiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polysaccharides - immunology</topic><topic>Polysaccharides - isolation & purification</topic><topic>Retrospective Clinical Research Report</topic><topic>Retrospective Studies</topic><topic>Sputum - microbiology</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Huan-Huan</creatorcontrib><creatorcontrib>Chen, Yan-Xiao</creatorcontrib><creatorcontrib>Fang, Shuang-Yan</creatorcontrib><collection>SAGE Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Huan-Huan</au><au>Chen, Yan-Xiao</au><au>Fang, Shuang-Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological features of isolated pulmonary cryptococcosis in HIV-negative patients</atitle><jtitle>Journal of international medical research</jtitle><addtitle>J Int Med Res</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>48</volume><issue>6</issue><spage>300060520927877</spage><epage>300060520927877</epage><pages>300060520927877-300060520927877</pages><issn>0300-0605</issn><eissn>1473-2300</eissn><abstract>Objective
To analyse the clinicopathological features of isolated pulmonary cryptococcosis in human immunodeficiency virus (HIV)-negative patients.
Methods
This retrospective study analysed the following data from HIV-negative patients diagnosed with pulmonary cryptococcosis: demographics, underlying diseases, clinical manifestations on admission, laboratory tests, imaging data, results of histopathology, treatment options and outcomes. Sputum samples from all patients were collected and assessed for the presence of yeast or fungi. Cryptococcal antigen testing was performed for some patients. Histopathological analysis was also undertaken for some samples of lung tissue.
Results
The study analysed 37 patients (22 males). Thirteen (35.14%) patients were asymptomatic, 24 (64.86%) were symptomatic and 17 (45.95%) patients had no underlying disease. Out of 25 tested patients, 23 (92.00%) tested positive on the serum cryptococcal capsular polysaccharide antigen test. During 6 to 24 months of follow-up, all 37 patients that were either treated with or without antifungal therapy alone or combined with surgical resection showed complete recovery. One patient made a full recovery without any treatment.
Conclusion
Early identification of pulmonary cryptococcosis in HIV-negative patients and timely detection of cryptococcal antigens in serum or respiratory specimens may help to improve diagnosis, prognosis and treatment of the disease.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>32527202</pmid><doi>10.1177/0300060520927877</doi><orcidid>https://orcid.org/0000-0001-8324-9570</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SAGE Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Antifungal Agents - therapeutic use Antigens Antigens, Fungal - immunology Antigens, Fungal - isolation & purification Asymptomatic Infections Cryptococcosis - diagnosis Cryptococcosis - drug therapy Cryptococcosis - immunology Cryptococcosis - microbiology Cryptococcus - immunology Cryptococcus - isolation & purification Female Follow-Up Studies HIV Human immunodeficiency virus Humans Lung - diagnostic imaging Lung - immunology Lung - microbiology Lung Diseases, Fungal - diagnosis Lung Diseases, Fungal - drug therapy Lung Diseases, Fungal - immunology Lung Diseases, Fungal - microbiology Male Middle Aged Polysaccharides - immunology Polysaccharides - isolation & purification Retrospective Clinical Research Report Retrospective Studies Sputum - microbiology Tomography, X-Ray Computed |
| title | Clinicopathological features of isolated pulmonary cryptococcosis in HIV-negative patients |
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