Preliminary evidence of anxiolytic effects of the CRF 1 receptor antagonist R317573 in the 7.5% CO 2 proof-of-concept experimental model of human anxiety

We have validated the use of prolonged inhalation of 7.5% carbon dioxide (CO 2 ) as a human model of anxiety and have shown that drugs from two prototypical classes of anxiolytics, benzodiazepines and a serotonin reuptake inhibitor, attenuate CO 2 -induced symptoms ( Bailey et al., 2007a ). Preclini...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2011-09, Vol.25 (9), p.1199-1206
Hauptverfasser:	Bailey, Jayne E, Papadopoulos, Andreas, Diaper, Alison, Phillips, Suzanne, Schmidt, ME, van der Ark, P, Dourish, Colin T, Dawson, Gerard R, Nutt, David J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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