A compartment model to calculate time-dependent concentration profiles of topically applied chemical compounds in the anterior compartments of the rabbit eye

Hitherto, none of the existing in vitro methods has been convincingly demonstrated to be suitable as a replacement for the Draize rabbit eye irritation test. We examine the hypothesis that one reason for this is that insufficient consideration has been given to the differences in the effective conce...

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Veröffentlicht in:	ATLA. Alternatives to laboratory animals 2001-05, Vol.29 (3), p.347-365
Hauptverfasser:	POSPISIL, Heike, HOLZHÜTTER, Hermann-Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - pharmacokinetics 4-Butyrolactone - toxicity Administration, Topical Adrenergic beta-Antagonists - pharmacokinetics Animals Anterior Eye Segment - drug effects Anterior Eye Segment - metabolism Biological and medical sciences Conjunctiva - drug effects Conjunctiva - metabolism Dose-Response Relationship, Drug Eye Injuries - chemically induced General aspects. Methods Irritants - pharmacokinetics Irritants - toxicity Kinetics Medical sciences Models, Biological Ophthalmic Solutions - pharmacokinetics Pharmacokinetics Rabbits Toxicity Tests - methods Toxicology
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