Stentless Valves Treated by the L-Hydro Process in the Aortic Position in Sheep
Calcification of glutaraldehyde-treated bioprosthetic heart valves is a major cause of long-term failure. We studied porcine aortic valves treated by the L-Hydro process and implanted into 14 juvenile sheep (group 1). Another 10 sheep were implanted with glutaraldehyde-treated porcine bioprostheses...
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| Veröffentlicht in: | Asian cardiovascular & thoracic annals 2007-10, Vol.15 (5), p.413-417 |
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| creator | Santos, Paulo C Gerola, Luis R Casagrande, Ivan Buffolo, Enio Cheung, David T |
| description | Calcification of glutaraldehyde-treated bioprosthetic heart valves is a major cause of long-term failure. We studied porcine aortic valves treated by the L-Hydro process and implanted into 14 juvenile sheep (group 1). Another 10 sheep were implanted with glutaraldehyde-treated porcine bioprostheses (group 2). The animals were sacrificed after 150 days and the explanted valves were analyzed for calcification. Hemodynamic measurements by echocardiography and angiography were carried out prior to sacrifice. Macroscopic analysis showed calcification and loss of mobility of the leaflets in all group 2 implants and in one group 1 implant. Light microscopy showed foci of calcification in all group 2 implants and in 3 valves from group 1. A significant reduction in the level of calcification was found in porcine bioprostheses treated by the L-Hydro process and implanted into the juvenile sheep model. |
| doi_str_mv | 10.1177/021849230701500511 |
| format | Article |
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We studied porcine aortic valves treated by the L-Hydro process and implanted into 14 juvenile sheep (group 1). Another 10 sheep were implanted with glutaraldehyde-treated porcine bioprostheses (group 2). The animals were sacrificed after 150 days and the explanted valves were analyzed for calcification. Hemodynamic measurements by echocardiography and angiography were carried out prior to sacrifice. Macroscopic analysis showed calcification and loss of mobility of the leaflets in all group 2 implants and in one group 1 implant. Light microscopy showed foci of calcification in all group 2 implants and in 3 valves from group 1. A significant reduction in the level of calcification was found in porcine bioprostheses treated by the L-Hydro process and implanted into the juvenile sheep model.</description><identifier>ISSN: 0218-4923</identifier><identifier>EISSN: 1816-5370</identifier><identifier>DOI: 10.1177/021849230701500511</identifier><identifier>PMID: 17911070</identifier><language>eng</language><publisher>London, England: Asian Soc Cardio Surg</publisher><subject>Animals ; Aortic Valve - pathology ; Aortic Valve - physiopathology ; Aortic Valve - surgery ; Bioprosthesis ; Calcinosis - chemically induced ; Calcinosis - pathology ; Calcinosis - physiopathology ; Equipment Failure Analysis ; Female ; Fixatives - adverse effects ; Glutaral - adverse effects ; Heart Valve Diseases - chemically induced ; Heart Valve Diseases - pathology ; Heart Valve Diseases - physiopathology ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation - instrumentation ; Hemodynamics ; Male ; Models, Animal ; Prosthesis Design ; Prosthesis Failure ; Sheep ; Tissue Fixation - methods ; Treatment Outcome</subject><ispartof>Asian cardiovascular & thoracic annals, 2007-10, Vol.15 (5), p.413-417</ispartof><rights>2007 SAGE Publications</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c245t-69d9062668277804b3bcc01d81b41ba42fd855a52f7d39fff39463afca7e893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/021849230701500511$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/021849230701500511$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17911070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santos, Paulo C</creatorcontrib><creatorcontrib>Gerola, Luis R</creatorcontrib><creatorcontrib>Casagrande, Ivan</creatorcontrib><creatorcontrib>Buffolo, Enio</creatorcontrib><creatorcontrib>Cheung, David T</creatorcontrib><title>Stentless Valves Treated by the L-Hydro Process in the Aortic Position in Sheep</title><title>Asian cardiovascular & thoracic annals</title><addtitle>Asian Cardiovasc Thorac Ann</addtitle><description>Calcification of glutaraldehyde-treated bioprosthetic heart valves is a major cause of long-term failure. We studied porcine aortic valves treated by the L-Hydro process and implanted into 14 juvenile sheep (group 1). Another 10 sheep were implanted with glutaraldehyde-treated porcine bioprostheses (group 2). The animals were sacrificed after 150 days and the explanted valves were analyzed for calcification. Hemodynamic measurements by echocardiography and angiography were carried out prior to sacrifice. Macroscopic analysis showed calcification and loss of mobility of the leaflets in all group 2 implants and in one group 1 implant. Light microscopy showed foci of calcification in all group 2 implants and in 3 valves from group 1. A significant reduction in the level of calcification was found in porcine bioprostheses treated by the L-Hydro process and implanted into the juvenile sheep model.</description><subject>Animals</subject><subject>Aortic Valve - pathology</subject><subject>Aortic Valve - physiopathology</subject><subject>Aortic Valve - surgery</subject><subject>Bioprosthesis</subject><subject>Calcinosis - chemically induced</subject><subject>Calcinosis - pathology</subject><subject>Calcinosis - physiopathology</subject><subject>Equipment Failure Analysis</subject><subject>Female</subject><subject>Fixatives - adverse effects</subject><subject>Glutaral - adverse effects</subject><subject>Heart Valve Diseases - chemically induced</subject><subject>Heart Valve Diseases - pathology</subject><subject>Heart Valve Diseases - physiopathology</subject><subject>Heart Valve Prosthesis</subject><subject>Heart Valve Prosthesis Implantation - instrumentation</subject><subject>Hemodynamics</subject><subject>Male</subject><subject>Models, Animal</subject><subject>Prosthesis Design</subject><subject>Prosthesis Failure</subject><subject>Sheep</subject><subject>Tissue Fixation - methods</subject><subject>Treatment Outcome</subject><issn>0218-4923</issn><issn>1816-5370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kNFKwzAUhoMobk5fwAvpC9TlJE2TXI6hThhssOFtSNtkzejakXTK3t7WDrwQvDpw-L7_cH6EHgE_A3A-xQREIgnFHAPDmAFcoTEISGNGOb5G4x6Ie2KE7kLYY4wpUHGLRsAlQKeN0WrTmrqtTAjRh64-TYi23ujWFFF2jtrSRMt4cS58E619k_eUq3_Ws8a3Lo_WTXCta-p-vSmNOd6jG6urYB4uc4I2ry_b-SJert7e57NlnJOEtXEqC4lTkqaCcC5wktEszzEUArIEMp0QWwjGNCOWF1Raa6lMUqptrrkRkk4QGVJz34TgjVVH7w7anxVg1Xej_nbTSU-DdDxlB1P8KpcyOmA6AEHvjNo3J193L_wfGQ9G6Xbll_NGhYOuqu4AKB2crnXdRwBTTCVA6Te6t3sn</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Santos, Paulo C</creator><creator>Gerola, Luis R</creator><creator>Casagrande, Ivan</creator><creator>Buffolo, Enio</creator><creator>Cheung, David T</creator><general>Asian Soc Cardio Surg</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200710</creationdate><title>Stentless Valves Treated by the L-Hydro Process in the Aortic Position in Sheep</title><author>Santos, Paulo C ; Gerola, Luis R ; Casagrande, Ivan ; Buffolo, Enio ; Cheung, David T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c245t-69d9062668277804b3bcc01d81b41ba42fd855a52f7d39fff39463afca7e893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Aortic Valve - pathology</topic><topic>Aortic Valve - physiopathology</topic><topic>Aortic Valve - surgery</topic><topic>Bioprosthesis</topic><topic>Calcinosis - chemically induced</topic><topic>Calcinosis - pathology</topic><topic>Calcinosis - physiopathology</topic><topic>Equipment Failure Analysis</topic><topic>Female</topic><topic>Fixatives - adverse effects</topic><topic>Glutaral - adverse effects</topic><topic>Heart Valve Diseases - chemically induced</topic><topic>Heart Valve Diseases - pathology</topic><topic>Heart Valve Diseases - physiopathology</topic><topic>Heart Valve Prosthesis</topic><topic>Heart Valve Prosthesis Implantation - instrumentation</topic><topic>Hemodynamics</topic><topic>Male</topic><topic>Models, Animal</topic><topic>Prosthesis Design</topic><topic>Prosthesis Failure</topic><topic>Sheep</topic><topic>Tissue Fixation - methods</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Santos, Paulo C</creatorcontrib><creatorcontrib>Gerola, Luis R</creatorcontrib><creatorcontrib>Casagrande, Ivan</creatorcontrib><creatorcontrib>Buffolo, Enio</creatorcontrib><creatorcontrib>Cheung, David T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Asian cardiovascular & thoracic annals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santos, Paulo C</au><au>Gerola, Luis R</au><au>Casagrande, Ivan</au><au>Buffolo, Enio</au><au>Cheung, David T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stentless Valves Treated by the L-Hydro Process in the Aortic Position in Sheep</atitle><jtitle>Asian cardiovascular & thoracic annals</jtitle><addtitle>Asian Cardiovasc Thorac Ann</addtitle><date>2007-10</date><risdate>2007</risdate><volume>15</volume><issue>5</issue><spage>413</spage><epage>417</epage><pages>413-417</pages><issn>0218-4923</issn><eissn>1816-5370</eissn><abstract>Calcification of glutaraldehyde-treated bioprosthetic heart valves is a major cause of long-term failure. We studied porcine aortic valves treated by the L-Hydro process and implanted into 14 juvenile sheep (group 1). Another 10 sheep were implanted with glutaraldehyde-treated porcine bioprostheses (group 2). The animals were sacrificed after 150 days and the explanted valves were analyzed for calcification. Hemodynamic measurements by echocardiography and angiography were carried out prior to sacrifice. Macroscopic analysis showed calcification and loss of mobility of the leaflets in all group 2 implants and in one group 1 implant. Light microscopy showed foci of calcification in all group 2 implants and in 3 valves from group 1. A significant reduction in the level of calcification was found in porcine bioprostheses treated by the L-Hydro process and implanted into the juvenile sheep model.</abstract><cop>London, England</cop><pub>Asian Soc Cardio Surg</pub><pmid>17911070</pmid><doi>10.1177/021849230701500511</doi><tpages>5</tpages></addata></record> |
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| ispartof | Asian cardiovascular & thoracic annals, 2007-10, Vol.15 (5), p.413-417 |
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| subjects | Animals Aortic Valve - pathology Aortic Valve - physiopathology Aortic Valve - surgery Bioprosthesis Calcinosis - chemically induced Calcinosis - pathology Calcinosis - physiopathology Equipment Failure Analysis Female Fixatives - adverse effects Glutaral - adverse effects Heart Valve Diseases - chemically induced Heart Valve Diseases - pathology Heart Valve Diseases - physiopathology Heart Valve Prosthesis Heart Valve Prosthesis Implantation - instrumentation Hemodynamics Male Models, Animal Prosthesis Design Prosthesis Failure Sheep Tissue Fixation - methods Treatment Outcome |
| title | Stentless Valves Treated by the L-Hydro Process in the Aortic Position in Sheep |
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