The Effect of Adenotonsillectomy in the Production of IGF-1 (Insulin-like Growth Factor-1) in Children

Objective: Airway obstruction caused by adenotonsillar hypertrophy is the main cause of snoring and sleep apnea in children and often associated with several other signs and symptoms, including growth development. The objective of this study was to evaluate the effect of adenotonsillectomy in the pr...

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Veröffentlicht in:Otolaryngology-head and neck surgery 2011-08, Vol.145 (2_suppl), p.P247-P248
Hauptverfasser: Pascoto, Gabriela R., Abreu, Cassiana, Santos, Fabio P., Pignatari, Shirley S. N., Stamm, Aldo E. C., Weber, Raimar
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container_end_page P248
container_issue 2_suppl
container_start_page P247
container_title Otolaryngology-head and neck surgery
container_volume 145
creator Pascoto, Gabriela R.
Abreu, Cassiana
Santos, Fabio P.
Pignatari, Shirley S. N.
Stamm, Aldo E. C.
Weber, Raimar
description Objective: Airway obstruction caused by adenotonsillar hypertrophy is the main cause of snoring and sleep apnea in children and often associated with several other signs and symptoms, including growth development. The objective of this study was to evaluate the effect of adenotonsillectomy in the production of IGF-1 (insulin-like growth factor-1) in children. Method: A total of 26 children of both sexes with adenotonsillar hypertrophy with formal indication for adenotonsillectomy (study group) and 21 control children (with indication for surgery for other reasons, eg, postectomy) were submitted to evaluation of peripheral blood IGF-1. The samples were taken immediately preoperatively and 30 days after surgery. Results: The preoperative levels of IGF-1 showed values within the normal range for age in both groups. Two children in the study group had values below normal for their age. The comparison of pre- and postoperative levels in children undergoing tonsillectomy showed a statistically significant increase (P < .01) by Student t test for paired samples. The 2 children with preoperative values below normal for age recovered normal levels of IGF-1 after surgery. Conclusion: The data from our study suggest that adenotonsillar hypertrophy, resulting in snoring and sleep apnea can affect negatively the production of circulating IGF-1, probably related to the disturbances of height and growth development, and demonstrate that adenotonsillectomy contributes to enhancing and restoring the values of IGF-1.
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Results: The preoperative levels of IGF-1 showed values within the normal range for age in both groups. Two children in the study group had values below normal for their age. The comparison of pre- and postoperative levels in children undergoing tonsillectomy showed a statistically significant increase (P &lt; .01) by Student t test for paired samples. The 2 children with preoperative values below normal for age recovered normal levels of IGF-1 after surgery. Conclusion: The data from our study suggest that adenotonsillar hypertrophy, resulting in snoring and sleep apnea can affect negatively the production of circulating IGF-1, probably related to the disturbances of height and growth development, and demonstrate that adenotonsillectomy contributes to enhancing and restoring the values of IGF-1.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1177/0194599811415823a368</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><ispartof>Otolaryngology-head and neck surgery, 2011-08, Vol.145 (2_suppl), p.P247-P248</ispartof><rights>Official journal of the American Academy of Otolaryngology–Head and Neck Surgery Foundation 2011</rights><rights>2011 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2376-ba7af0e1bd67a23ff712870dc1355b416bc36483d83fbde71fbd12465a5654113</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0194599811415823a368$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0194599811415823a368$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,777,781,1412,21800,27905,27906,43602,43603,45555,45556</link.rule.ids></links><search><creatorcontrib>Pascoto, Gabriela R.</creatorcontrib><creatorcontrib>Abreu, Cassiana</creatorcontrib><creatorcontrib>Santos, Fabio P.</creatorcontrib><creatorcontrib>Pignatari, Shirley S. 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C.</au><au>Weber, Raimar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Adenotonsillectomy in the Production of IGF-1 (Insulin-like Growth Factor-1) in Children</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><date>2011-08</date><risdate>2011</risdate><volume>145</volume><issue>2_suppl</issue><spage>P247</spage><epage>P248</epage><pages>P247-P248</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Objective: Airway obstruction caused by adenotonsillar hypertrophy is the main cause of snoring and sleep apnea in children and often associated with several other signs and symptoms, including growth development. The objective of this study was to evaluate the effect of adenotonsillectomy in the production of IGF-1 (insulin-like growth factor-1) in children. Method: A total of 26 children of both sexes with adenotonsillar hypertrophy with formal indication for adenotonsillectomy (study group) and 21 control children (with indication for surgery for other reasons, eg, postectomy) were submitted to evaluation of peripheral blood IGF-1. The samples were taken immediately preoperatively and 30 days after surgery. Results: The preoperative levels of IGF-1 showed values within the normal range for age in both groups. Two children in the study group had values below normal for their age. The comparison of pre- and postoperative levels in children undergoing tonsillectomy showed a statistically significant increase (P &lt; .01) by Student t test for paired samples. The 2 children with preoperative values below normal for age recovered normal levels of IGF-1 after surgery. Conclusion: The data from our study suggest that adenotonsillar hypertrophy, resulting in snoring and sleep apnea can affect negatively the production of circulating IGF-1, probably related to the disturbances of height and growth development, and demonstrate that adenotonsillectomy contributes to enhancing and restoring the values of IGF-1.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><doi>10.1177/0194599811415823a368</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record>
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title The Effect of Adenotonsillectomy in the Production of IGF-1 (Insulin-like Growth Factor-1) in Children
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