Renal Lesions Induced by Ochratoxin A Exposure in the F344 Rat

Groups of 80 male and female F344 rats were exposed by gavage to ochratoxin A, a naturally occurring mycotoxin, at levels of 21, 70, and 210 μg/kg body weight for up to 2 years. Ochratoxin A induced nonneoplastic renal tubular epithelial changes consisting of cytoplasmic alteration, karyomegaly, deg...

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Veröffentlicht in:	Toxicologic pathology 1992-01, Vol.20 (2), p.236-245
Hauptverfasser:	Boorman, Gary A., Mcdonald, Margarita R., Imoto, Seiichi, Persing, Ronald
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - chemically induced Adenoma - pathology Animals Biological and medical sciences Carcinoma - chemically induced Carcinoma - pathology Female Hyperplasia - chemically induced Hyperplasia - pathology Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - pathology Kidney Neoplasms - chemically induced Kidney Neoplasms - pathology Kidney Tubules - pathology Male Medical sciences Ochratoxins - toxicity Plant poisons toxicology Rats Rats, Inbred F344 Toxicology
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