Elevated Lipid Peroxidation in Rats Induced by Dietary Lipids and N-Nitrosodimethylamine and its Inhibition by Indomethacin Monitored Via Ethane Exhalation
The effect of dietary lipids alone or in combination with an administered carcinogen, N-nitrosodimethylamine (NDMA), on whole body lipid peroxidation was studied in rats in vivo. Groups of rats were fed diets containing 2%, 12.5%, or 25% of either saturated or polyunsaturated fat. Lipid peroxidation...
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| Veröffentlicht in: | Toxicologic pathology 1987-01, Vol.15 (1), p.93-96 |
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| container_title | Toxicologic pathology |
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| creator | Hietanen, Eino Ahotupa, Markku Béréziat, Jean-Claude Bussacchini, Valeria Camus, Anne-Marie Bartsch, Helmut |
| description | The effect of dietary lipids alone or in combination with an administered carcinogen, N-nitrosodimethylamine (NDMA), on whole body lipid peroxidation was studied in rats in vivo. Groups of rats were fed diets containing 2%, 12.5%, or 25% of either saturated or polyunsaturated fat. Lipid peroxidation in individual animals was determined by measuring the concentration of ethane in exhaled air. Increased ethane exhalation was found in rats when the amount of dietary fat was increased from 2% to 12.5%, but animals receiving 12.5% or 25% fat in the diet exhaled ethane at similar rates. Rats consuming polyunsaturated fat exhaled more ethane than those eating saturated fat. In all groups, NDMA administration drastically increased ethane exhalation. Indomethacin completely blocked the increase in ethane exhalation caused by dietary lipids. |
| doi_str_mv | 10.1177/019262338701500113 |
| format | Article |
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Indomethacin completely blocked the increase in ethane exhalation caused by dietary lipids.</description><identifier>ISSN: 0192-6233</identifier><identifier>EISSN: 1533-1601</identifier><identifier>DOI: 10.1177/019262338701500113</identifier><identifier>PMID: 3576078</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Breath Tests ; Dietary Fats - pharmacology ; Dimethylnitrosamine - pharmacology ; Ethane - metabolism ; Indomethacin - pharmacology ; Lipid Peroxides - metabolism ; Male ; Rats ; Rats, Inbred Strains</subject><ispartof>Toxicologic pathology, 1987-01, Vol.15 (1), p.93-96</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3633-b498145b9715ed9b7272a24ad6aad8bb6ac6186680416bec4383b87a17560a4d3</citedby><cites>FETCH-LOGICAL-c3633-b498145b9715ed9b7272a24ad6aad8bb6ac6186680416bec4383b87a17560a4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/019262338701500113$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/019262338701500113$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,4010,21798,27900,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3576078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hietanen, Eino</creatorcontrib><creatorcontrib>Ahotupa, Markku</creatorcontrib><creatorcontrib>Béréziat, Jean-Claude</creatorcontrib><creatorcontrib>Bussacchini, Valeria</creatorcontrib><creatorcontrib>Camus, Anne-Marie</creatorcontrib><creatorcontrib>Bartsch, Helmut</creatorcontrib><title>Elevated Lipid Peroxidation in Rats Induced by Dietary Lipids and N-Nitrosodimethylamine and its Inhibition by Indomethacin Monitored Via Ethane Exhalation</title><title>Toxicologic pathology</title><addtitle>Toxicol Pathol</addtitle><description>The effect of dietary lipids alone or in combination with an administered carcinogen, N-nitrosodimethylamine (NDMA), on whole body lipid peroxidation was studied in rats in vivo. Groups of rats were fed diets containing 2%, 12.5%, or 25% of either saturated or polyunsaturated fat. Lipid peroxidation in individual animals was determined by measuring the concentration of ethane in exhaled air. Increased ethane exhalation was found in rats when the amount of dietary fat was increased from 2% to 12.5%, but animals receiving 12.5% or 25% fat in the diet exhaled ethane at similar rates. Rats consuming polyunsaturated fat exhaled more ethane than those eating saturated fat. In all groups, NDMA administration drastically increased ethane exhalation. Indomethacin completely blocked the increase in ethane exhalation caused by dietary lipids.</description><subject>Animals</subject><subject>Breath Tests</subject><subject>Dietary Fats - pharmacology</subject><subject>Dimethylnitrosamine - pharmacology</subject><subject>Ethane - metabolism</subject><subject>Indomethacin - pharmacology</subject><subject>Lipid Peroxides - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0192-6233</issn><issn>1533-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN9KwzAYxYMoc05fQBDyAnVJ0ybppcyqg_kHUW_LlyZzGW0z2k62Z_FlTdvhjeBV4Du_c8I5CF1Sck2pEFNCk5CHjElBaEwIpewIjWnMWEA5ocdo3AFBR5yis6ZZe0TSiIzQiMWCEyHH6DstzBe0RuOF3ViNX0ztdlZDa12FbYVfoW3wvNLb3CNqj2-taaHeD3SDodL4KXiybe0ap21p2tW-gNJWppdsb15ZZfs87_dRrqMg9-GPrrKtq33yhwWc-qv3pbsVFP3_5-hkCUVjLg7vBL3fpW-zh2DxfD-f3SyCnHHfVUWJbxWrRNDY6ESJUIQQRqA5gJZKccg5lZxLElGuTB4xyZQUQEXMCUSaTVA45Oa-RVObZbapbelbZpRk3dDZ36G96WowbbaqNPrXcljW69NBb-DTZGu3rSvf4b_EHwGUh6U</recordid><startdate>198701</startdate><enddate>198701</enddate><creator>Hietanen, Eino</creator><creator>Ahotupa, Markku</creator><creator>Béréziat, Jean-Claude</creator><creator>Bussacchini, Valeria</creator><creator>Camus, Anne-Marie</creator><creator>Bartsch, Helmut</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198701</creationdate><title>Elevated Lipid Peroxidation in Rats Induced by Dietary Lipids and N-Nitrosodimethylamine and its Inhibition by Indomethacin Monitored Via Ethane Exhalation</title><author>Hietanen, Eino ; Ahotupa, Markku ; Béréziat, Jean-Claude ; Bussacchini, Valeria ; Camus, Anne-Marie ; Bartsch, Helmut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3633-b498145b9715ed9b7272a24ad6aad8bb6ac6186680416bec4383b87a17560a4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Breath Tests</topic><topic>Dietary Fats - pharmacology</topic><topic>Dimethylnitrosamine - pharmacology</topic><topic>Ethane - metabolism</topic><topic>Indomethacin - pharmacology</topic><topic>Lipid Peroxides - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hietanen, Eino</creatorcontrib><creatorcontrib>Ahotupa, Markku</creatorcontrib><creatorcontrib>Béréziat, Jean-Claude</creatorcontrib><creatorcontrib>Bussacchini, Valeria</creatorcontrib><creatorcontrib>Camus, Anne-Marie</creatorcontrib><creatorcontrib>Bartsch, Helmut</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Toxicologic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hietanen, Eino</au><au>Ahotupa, Markku</au><au>Béréziat, Jean-Claude</au><au>Bussacchini, Valeria</au><au>Camus, Anne-Marie</au><au>Bartsch, Helmut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Lipid Peroxidation in Rats Induced by Dietary Lipids and N-Nitrosodimethylamine and its Inhibition by Indomethacin Monitored Via Ethane Exhalation</atitle><jtitle>Toxicologic pathology</jtitle><addtitle>Toxicol Pathol</addtitle><date>1987-01</date><risdate>1987</risdate><volume>15</volume><issue>1</issue><spage>93</spage><epage>96</epage><pages>93-96</pages><issn>0192-6233</issn><eissn>1533-1601</eissn><abstract>The effect of dietary lipids alone or in combination with an administered carcinogen, N-nitrosodimethylamine (NDMA), on whole body lipid peroxidation was studied in rats in vivo. Groups of rats were fed diets containing 2%, 12.5%, or 25% of either saturated or polyunsaturated fat. Lipid peroxidation in individual animals was determined by measuring the concentration of ethane in exhaled air. Increased ethane exhalation was found in rats when the amount of dietary fat was increased from 2% to 12.5%, but animals receiving 12.5% or 25% fat in the diet exhaled ethane at similar rates. Rats consuming polyunsaturated fat exhaled more ethane than those eating saturated fat. In all groups, NDMA administration drastically increased ethane exhalation. Indomethacin completely blocked the increase in ethane exhalation caused by dietary lipids.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>3576078</pmid><doi>10.1177/019262338701500113</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0192-6233 |
| ispartof | Toxicologic pathology, 1987-01, Vol.15 (1), p.93-96 |
| issn | 0192-6233 1533-1601 |
| language | eng |
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| source | MEDLINE; SAGE Complete; Alma/SFX Local Collection |
| subjects | Animals Breath Tests Dietary Fats - pharmacology Dimethylnitrosamine - pharmacology Ethane - metabolism Indomethacin - pharmacology Lipid Peroxides - metabolism Male Rats Rats, Inbred Strains |
| title | Elevated Lipid Peroxidation in Rats Induced by Dietary Lipids and N-Nitrosodimethylamine and its Inhibition by Indomethacin Monitored Via Ethane Exhalation |
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