Assessment of Cardiac Troponin I Responses in Nonhuman Primates during Restraint, Blood Collection, and Dosing in Preclinical Safety Studies

Limited information has been published on the use of cardiac troponin I (cTnI) as a biomarker of cardiac injury in monkeys. The purpose of these studies was to characterize the cTnI response seen in cynomolgus macaques during routine dosing and blood collection procedures typically used in preclinic...

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Veröffentlicht in:	Toxicologic pathology 2017-02, Vol.45 (2), p.335-343
Hauptverfasser:	Reagan, William J., Barnes, Robert, Harris, Peter, Summers, Sandy, Lopes, Sarah, Stubbs, Makeida, Blackwell, David, Steidl-Nichols, Jill
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - blood Blood Specimen Collection - methods Blood Specimen Collection - standards Blood Specimen Collection - veterinary Drug Evaluation, Preclinical - methods Drug Evaluation, Preclinical - standards Drug Evaluation, Preclinical - veterinary Heart - drug effects Macaca fascicularis Male Pharmaceutical Preparations - administration & dosage Restraint, Physical Troponin I - blood
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