Carcinogenicity Assessments of Biotechnology-Derived Pharmaceuticals: A Review of Approved Molecules and Best Practice Recommendations

An important safety consideration for developing new therapeutics is assessing the potential that the therapy will increase the risk of cancer. For biotherapeutics, traditional two-year rodent bioassays are often not scientifically applicable or feasible. This paper is a collaborative effort of indu...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Toxicologic Pathology 2010-06, Vol.38 (4), p.522-553
Hauptverfasser:	Vahle, John L., Finch, Gregory L., Heidel, Shawn M., Hovland, David N., Ivens, Inge, Parker, Suezanne, Ponce, Rafael A., Sachs, Clifford, Steigerwalt, Ronald, Short, Brian, Todd, Marque D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biopharmaceutics - methods Biotechnology - methods Carcinogenicity Tests - methods Drug Approval - methods Drug toxicity and drugs side effects treatment Drug-Related Side Effects and Adverse Reactions Humans Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!