P-glycoprotein: So Many Ways to Turn It On

Expression of the ABC transporter P‐glycoprotein (P‐gp or ABCB1) is associated with resistance to chemotherapy in cancer. However, early investigations into the regulation of ABCB1 expression revealed that the process is not a classical induction as observed for certain metabolizing enzymes. The pro...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of clinical pharmacology 2008-03, Vol.48 (3), p.365-378
Hauptverfasser:	Callaghan, Richard, Crowley, Emily, Biochem, M, Potter, Simon, Kerr, Ian D.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCB1 Animals ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism chemotherapy Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 Enzyme System - metabolism drug absorption drug elimination drug resistance Drug Resistance, Neoplasm Humans Models, Biological P-glycoprotein Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!