Pharmacokinetics and Safety of Single Intravenous Infusions of the Adenosine Agonist, AMP 579, in Patients with End-Stage Renal Insufficiency

The pharmacokinetics of an adenosine agonist (AMP 579) were characterized in patients with end‐stage renal disease compared to sex‐ and age‐matched healthy volunteers. All study participants were administered single AMP 579 doses of 50 μg/kg as a 6‐hour, constant‐rate intravenous infusion. Serial bl...

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Veröffentlicht in:	Journal of clinical pharmacology 2000-07, Vol.40 (7), p.745-751
Hauptverfasser:	Zannikos, Peter N., Jensen, Bradford K., Boutouyrie, Bruno X., Tripp, Lisa, Yongyi, Luo, McGowan, Tracy, Waldman, Scott A., Greenberg, Howard E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Cardiovascular system Female Humans Imidazoles - adverse effects Imidazoles - blood Imidazoles - pharmacokinetics Infusions, Intravenous Kidney Failure, Chronic - metabolism Male Medical sciences Middle Aged Miscellaneous Pharmacology. Drug treatments Protein Binding Purinergic P1 Receptor Agonists Pyridines - adverse effects Pyridines - blood Pyridines - pharmacokinetics
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