Tissue Activity and Cellular Localization of Human Semicarbazide-sensitive Amine Oxidase
SUMMARY Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic aromatic and aliphatic monoamines. To assess whether its physiological role in humans is restricted to oxidation, we used an immunohistochemical ap...
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| Veröffentlicht in: | The journal of histochemistry and cytochemistry 2001-02, Vol.49 (2), p.209-217 |
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| container_title | The journal of histochemistry and cytochemistry |
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| creator | Andrés, Noemí Lizcano, José Miguel Rodríguez, Manuel J. Romera, Manuel Unzeta, Mercedes Mahy, Nicole |
| description | SUMMARY Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic aromatic and aliphatic monoamines. To assess whether its physiological role in humans is restricted to oxidation, we used an immunohistochemical approach to examine the cellular localization of SSAO in human peripheral tissues (adrenal gland, duodenum, heart, kidney, lung, liver, pancreas, spleen, thyroid gland, and blood vessels) and also analyzed its subcellular localization. The results are in agreement with the specific activities also determined in the same samples and are discussed with reference to the tissue distribution of monoamine oxidase A and B. Together with the oxidative deamination of monoamines, SSAO cellular localization indicates that, in most human peripheral tissues, it might participate in the regulation of physiological processes via H2O2 generation. (J Histochem Cytochem 49:209–217, 2001) |
| doi_str_mv | 10.1177/002215540104900208 |
| format | Article |
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To assess whether its physiological role in humans is restricted to oxidation, we used an immunohistochemical approach to examine the cellular localization of SSAO in human peripheral tissues (adrenal gland, duodenum, heart, kidney, lung, liver, pancreas, spleen, thyroid gland, and blood vessels) and also analyzed its subcellular localization. The results are in agreement with the specific activities also determined in the same samples and are discussed with reference to the tissue distribution of monoamine oxidase A and B. Together with the oxidative deamination of monoamines, SSAO cellular localization indicates that, in most human peripheral tissues, it might participate in the regulation of physiological processes via H2O2 generation. 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To assess whether its physiological role in humans is restricted to oxidation, we used an immunohistochemical approach to examine the cellular localization of SSAO in human peripheral tissues (adrenal gland, duodenum, heart, kidney, lung, liver, pancreas, spleen, thyroid gland, and blood vessels) and also analyzed its subcellular localization. The results are in agreement with the specific activities also determined in the same samples and are discussed with reference to the tissue distribution of monoamine oxidase A and B. Together with the oxidative deamination of monoamines, SSAO cellular localization indicates that, in most human peripheral tissues, it might participate in the regulation of physiological processes via H2O2 generation. (J Histochem Cytochem 49:209–217, 2001)</description><subject>Amine Oxidase (Copper-Containing) - antagonists & inhibitors</subject><subject>Amine Oxidase (Copper-Containing) - metabolism</subject><subject>Cell Line</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Immunohistochemistry</subject><subject>Organ Specificity</subject><subject>Semicarbazides - pharmacology</subject><issn>0022-1554</issn><issn>1551-5044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlb_gAfJH1ibySbZ5liKWqHQgxW8LbPZrKTsR0l2xfbXm9KCB8HTMMPzvDAvIffAHgGybMoY5yClYMCEjgubXZBxPEAimRCXZHwEkiMxIjchbBkDIeTsmowAQCo102PysXEhDJbOTe--XL-n2JZ0Yet6qNHTVWewdgfsXdfSrqLLocGWvtnGGfQFHlxpk2Db4KIcMxrXWrr-diUGe0uuKqyDvTvPCXl_ftoslslq_fK6mK8SI4Tuk1QKKYxRqmLKoOLIC65BSS0MU0UV_xRQIlpT8kpLZqRKgWcCRaYZphmmE8JPucZ3IXhb5TvvGvT7HFh-rCn_W1OUHk7SbigaW_4q514iMD0BAT9tvu0G38Yn_ov8AZcFb4I</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Andrés, Noemí</creator><creator>Lizcano, José Miguel</creator><creator>Rodríguez, Manuel J.</creator><creator>Romera, Manuel</creator><creator>Unzeta, Mercedes</creator><creator>Mahy, Nicole</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20010201</creationdate><title>Tissue Activity and Cellular Localization of Human Semicarbazide-sensitive Amine Oxidase</title><author>Andrés, Noemí ; Lizcano, José Miguel ; Rodríguez, Manuel J. ; Romera, Manuel ; Unzeta, Mercedes ; Mahy, Nicole</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-35454cc66f06ca62a2b2916594c06bf11741daaecd2f950c5631274a4790a37a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amine Oxidase (Copper-Containing) - antagonists & inhibitors</topic><topic>Amine Oxidase (Copper-Containing) - metabolism</topic><topic>Cell Line</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Immunohistochemistry</topic><topic>Organ Specificity</topic><topic>Semicarbazides - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andrés, Noemí</creatorcontrib><creatorcontrib>Lizcano, José Miguel</creatorcontrib><creatorcontrib>Rodríguez, Manuel J.</creatorcontrib><creatorcontrib>Romera, Manuel</creatorcontrib><creatorcontrib>Unzeta, Mercedes</creatorcontrib><creatorcontrib>Mahy, Nicole</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The journal of histochemistry and cytochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andrés, Noemí</au><au>Lizcano, José Miguel</au><au>Rodríguez, Manuel J.</au><au>Romera, Manuel</au><au>Unzeta, Mercedes</au><au>Mahy, Nicole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tissue Activity and Cellular Localization of Human Semicarbazide-sensitive Amine Oxidase</atitle><jtitle>The journal of histochemistry and cytochemistry</jtitle><addtitle>J Histochem Cytochem</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>49</volume><issue>2</issue><spage>209</spage><epage>217</epage><pages>209-217</pages><issn>0022-1554</issn><eissn>1551-5044</eissn><abstract>SUMMARY Semicarbazide-sensitive amine oxidase (SSAO), widely distributed in highly vascularized mammalian tissues, metabolizes endogenous and xenobiotic aromatic and aliphatic monoamines. 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| subjects | Amine Oxidase (Copper-Containing) - antagonists & inhibitors Amine Oxidase (Copper-Containing) - metabolism Cell Line Enzyme Inhibitors - pharmacology Humans Immunoblotting Immunohistochemistry Organ Specificity Semicarbazides - pharmacology |
| title | Tissue Activity and Cellular Localization of Human Semicarbazide-sensitive Amine Oxidase |
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