Effect of Antimicrobial Agents on Root Surface Caries, Alveolar Bone Loss, and Microflora in Rice Rats
Two antimicrobial agents, 9-aminoacridine (0.2%) and minocycline (0.2%), were evaluated for their efficacy in inhibiting root surface caries, bone loss, and microflora in rice rats. A solution of 5000 ppm fluoride was used as a positive control for the inhibition of root surface caries, and double-d...
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| Veröffentlicht in: | Journal of dental research 1986-05, Vol.65 (5), p.695-697 |
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| creator | Toth, A. Beck, F.M. Beck, E.X. Flaxman, N. Rosen, S. |
| description | Two antimicrobial agents, 9-aminoacridine (0.2%) and minocycline (0.2%), were evaluated for their efficacy in inhibiting root surface caries, bone loss, and microflora in rice rats. A solution of 5000 ppm fluoride was used as a positive control for the inhibition of root surface caries, and double-distilled water was used as a negative control group. Each rat was treated by having its molar teeth swabbed 2 x per day with the prescribed agent in its group for nine weeks. Root caries reduction in the minocycline and fluoride groups was not significantly different, but the reduction was significantly greater than in the 9-aminoacridine group, with the caries score in all three groups being significantly less than that in the water control. Bone loss reduction for the minocycline group was significantly greater than that for any other group. |
| doi_str_mv | 10.1177/00220345860650051301 |
| format | Article |
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A solution of 5000 ppm fluoride was used as a positive control for the inhibition of root surface caries, and double-distilled water was used as a negative control group. Each rat was treated by having its molar teeth swabbed 2 x per day with the prescribed agent in its group for nine weeks. Root caries reduction in the minocycline and fluoride groups was not significantly different, but the reduction was significantly greater than in the 9-aminoacridine group, with the caries score in all three groups being significantly less than that in the water control. Bone loss reduction for the minocycline group was significantly greater than that for any other group.</description><identifier>ISSN: 0022-0345</identifier><identifier>EISSN: 1544-0591</identifier><identifier>DOI: 10.1177/00220345860650051301</identifier><identifier>PMID: 3517096</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject><![CDATA[Alveolar Process - drug effects ; Aminacrine - administration & dosage ; Aminacrine - pharmacology ; Aminoacridines - pharmacology ; Animals ; Arvicolinae ; Bacteria - drug effects ; Bacteria - isolation & purification ; Bone Resorption - etiology ; Bone Resorption - physiopathology ; Bone Resorption - prevention & control ; Dental Caries - etiology ; Dental Caries - physiopathology ; Dental Caries - prevention & control ; Female ; Male ; Minocycline - administration & dosage ; Minocycline - pharmacology ; Periodontal Diseases - etiology ; Periodontal Diseases - physiopathology ; Periodontal Diseases - prevention & control ; Rats ; Sodium Fluoride - administration & dosage ; Sodium Fluoride - pharmacology ; Streptococcus sanguis - drug effects ; Streptococcus sanguis - isolation & purification ; Tetracyclines - pharmacology ; Tooth Root - drug effects]]></subject><ispartof>Journal of dental research, 1986-05, Vol.65 (5), p.695-697</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-fa98dcbe2f8d81bf37d79a93b6e968b126b2639475727c538c0baefed6697f903</citedby><cites>FETCH-LOGICAL-c344t-fa98dcbe2f8d81bf37d79a93b6e968b126b2639475727c538c0baefed6697f903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/00220345860650051301$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/00220345860650051301$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3517096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Toth, A.</creatorcontrib><creatorcontrib>Beck, F.M.</creatorcontrib><creatorcontrib>Beck, E.X.</creatorcontrib><creatorcontrib>Flaxman, N.</creatorcontrib><creatorcontrib>Rosen, S.</creatorcontrib><title>Effect of Antimicrobial Agents on Root Surface Caries, Alveolar Bone Loss, and Microflora in Rice Rats</title><title>Journal of dental research</title><addtitle>J Dent Res</addtitle><description>Two antimicrobial agents, 9-aminoacridine (0.2%) and minocycline (0.2%), were evaluated for their efficacy in inhibiting root surface caries, bone loss, and microflora in rice rats. A solution of 5000 ppm fluoride was used as a positive control for the inhibition of root surface caries, and double-distilled water was used as a negative control group. Each rat was treated by having its molar teeth swabbed 2 x per day with the prescribed agent in its group for nine weeks. Root caries reduction in the minocycline and fluoride groups was not significantly different, but the reduction was significantly greater than in the 9-aminoacridine group, with the caries score in all three groups being significantly less than that in the water control. Bone loss reduction for the minocycline group was significantly greater than that for any other group.</description><subject>Alveolar Process - drug effects</subject><subject>Aminacrine - administration & dosage</subject><subject>Aminacrine - pharmacology</subject><subject>Aminoacridines - pharmacology</subject><subject>Animals</subject><subject>Arvicolinae</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - isolation & purification</subject><subject>Bone Resorption - etiology</subject><subject>Bone Resorption - physiopathology</subject><subject>Bone Resorption - prevention & control</subject><subject>Dental Caries - etiology</subject><subject>Dental Caries - physiopathology</subject><subject>Dental Caries - prevention & control</subject><subject>Female</subject><subject>Male</subject><subject>Minocycline - administration & dosage</subject><subject>Minocycline - pharmacology</subject><subject>Periodontal Diseases - etiology</subject><subject>Periodontal Diseases - physiopathology</subject><subject>Periodontal Diseases - prevention & control</subject><subject>Rats</subject><subject>Sodium Fluoride - administration & dosage</subject><subject>Sodium Fluoride - pharmacology</subject><subject>Streptococcus sanguis - drug effects</subject><subject>Streptococcus sanguis - isolation & purification</subject><subject>Tetracyclines - pharmacology</subject><subject>Tooth Root - drug effects</subject><issn>0022-0345</issn><issn>1544-0591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1Kw0AQhRdRaq2-gcI-gNHZ_-xlLPUHKkLV67Cb7JaUNFt2U8G3N6HFK_FqYM75DjMHoWsCd4QodQ9AKTAucglSAAjCgJygKRGcZyA0OUXT0ZKNnnN0kdIGgGiaswmaMEEUaDlFfuG9q3ocPC66vtk2VQy2MS0u1q7rEw4dXoXQ4_d99KZyeG5i49ItLtovF1oT8UPoHF6GNOxMV-PXMcC3IRrcDGgzICvTp0t05k2b3NVxztDn4-Jj_pwt355e5sUyqxjnfeaNzuvKOurzOifWM1UrbTSz0mmZW0KlpZJproSiqhIsr8Aa510tpVZeA5shfsgdrkgpOl_uYrM18bskUI6tlX-1NmA3B2y3t1tX_0LHmgadHPRk1q7chH3shi_-z_wBbDp0kg</recordid><startdate>19860501</startdate><enddate>19860501</enddate><creator>Toth, A.</creator><creator>Beck, F.M.</creator><creator>Beck, E.X.</creator><creator>Flaxman, N.</creator><creator>Rosen, S.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19860501</creationdate><title>Effect of Antimicrobial Agents on Root Surface Caries, Alveolar Bone Loss, and Microflora in Rice Rats</title><author>Toth, A. ; Beck, F.M. ; Beck, E.X. ; Flaxman, N. ; Rosen, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-fa98dcbe2f8d81bf37d79a93b6e968b126b2639475727c538c0baefed6697f903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Alveolar Process - drug effects</topic><topic>Aminacrine - administration & dosage</topic><topic>Aminacrine - pharmacology</topic><topic>Aminoacridines - pharmacology</topic><topic>Animals</topic><topic>Arvicolinae</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - isolation & purification</topic><topic>Bone Resorption - etiology</topic><topic>Bone Resorption - physiopathology</topic><topic>Bone Resorption - prevention & control</topic><topic>Dental Caries - etiology</topic><topic>Dental Caries - physiopathology</topic><topic>Dental Caries - prevention & control</topic><topic>Female</topic><topic>Male</topic><topic>Minocycline - administration & dosage</topic><topic>Minocycline - pharmacology</topic><topic>Periodontal Diseases - etiology</topic><topic>Periodontal Diseases - physiopathology</topic><topic>Periodontal Diseases - prevention & control</topic><topic>Rats</topic><topic>Sodium Fluoride - administration & dosage</topic><topic>Sodium Fluoride - pharmacology</topic><topic>Streptococcus sanguis - drug effects</topic><topic>Streptococcus sanguis - isolation & purification</topic><topic>Tetracyclines - pharmacology</topic><topic>Tooth Root - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Toth, A.</creatorcontrib><creatorcontrib>Beck, F.M.</creatorcontrib><creatorcontrib>Beck, E.X.</creatorcontrib><creatorcontrib>Flaxman, N.</creatorcontrib><creatorcontrib>Rosen, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of dental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Toth, A.</au><au>Beck, F.M.</au><au>Beck, E.X.</au><au>Flaxman, N.</au><au>Rosen, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Antimicrobial Agents on Root Surface Caries, Alveolar Bone Loss, and Microflora in Rice Rats</atitle><jtitle>Journal of dental research</jtitle><addtitle>J Dent Res</addtitle><date>1986-05-01</date><risdate>1986</risdate><volume>65</volume><issue>5</issue><spage>695</spage><epage>697</epage><pages>695-697</pages><issn>0022-0345</issn><eissn>1544-0591</eissn><abstract>Two antimicrobial agents, 9-aminoacridine (0.2%) and minocycline (0.2%), were evaluated for their efficacy in inhibiting root surface caries, bone loss, and microflora in rice rats. A solution of 5000 ppm fluoride was used as a positive control for the inhibition of root surface caries, and double-distilled water was used as a negative control group. Each rat was treated by having its molar teeth swabbed 2 x per day with the prescribed agent in its group for nine weeks. Root caries reduction in the minocycline and fluoride groups was not significantly different, but the reduction was significantly greater than in the 9-aminoacridine group, with the caries score in all three groups being significantly less than that in the water control. Bone loss reduction for the minocycline group was significantly greater than that for any other group.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>3517096</pmid><doi>10.1177/00220345860650051301</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of dental research, 1986-05, Vol.65 (5), p.695-697 |
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| source | MEDLINE; SAGE Complete |
| subjects | Alveolar Process - drug effects Aminacrine - administration & dosage Aminacrine - pharmacology Aminoacridines - pharmacology Animals Arvicolinae Bacteria - drug effects Bacteria - isolation & purification Bone Resorption - etiology Bone Resorption - physiopathology Bone Resorption - prevention & control Dental Caries - etiology Dental Caries - physiopathology Dental Caries - prevention & control Female Male Minocycline - administration & dosage Minocycline - pharmacology Periodontal Diseases - etiology Periodontal Diseases - physiopathology Periodontal Diseases - prevention & control Rats Sodium Fluoride - administration & dosage Sodium Fluoride - pharmacology Streptococcus sanguis - drug effects Streptococcus sanguis - isolation & purification Tetracyclines - pharmacology Tooth Root - drug effects |
| title | Effect of Antimicrobial Agents on Root Surface Caries, Alveolar Bone Loss, and Microflora in Rice Rats |
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