Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenylketonuric patients
Six normal subjects each ingested a single 12 ounce can of a diet cola (Diet Coke) providing 184 mg aspartame (APM), of which 104 mg is phenylalanine (Phe), and, on another occasion, a single 12 ounce can of regular cola (Coke Classic). Neither cola significantly affected plasma concentrations of Ph...
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| Veröffentlicht in: | Clinical pediatrics 1992-07, Vol.31 (7), p.394-399 |
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| creator | Mackey, S.A. (Pennsylvania State University, Hershey) Berlin, C.M. Jr |
| description | Six normal subjects each ingested a single 12 ounce can of a diet cola (Diet Coke) providing 184 mg aspartame (APM), of which 104 mg is phenylalanine (Phe), and, on another occasion, a single 12 ounce can of regular cola (Coke Classic). Neither cola significantly affected plasma concentrations of Phe or tyrosine over the three-hour postingestion study period. Each of five homozygous phenylketonuric (PKU) subjects (ages 11, 16, 17, 21, and 23 years) ingested a single 12 ounce can of the same diet cola. In these five subjects (three with classic PKU and two with hyperphenylalinemia), the increase in plasma Phe concentrations varied from 0.26 mg/dL to 1.77 mg/dL two or three hours after ingestion (baseline levels, 5.04 to 17.2 mg/dL). Tyrosine concentrations did not differ significantly from baseline levels. The data indicate that ingestion of dietary Phe, as supplied in a single can of diet cola, is readily handled in both normal and PKU subjects. The small increases in plasma Phe concentrations in the homozygous PKU patients are not considered clinically significant |
| doi_str_mv | 10.1177/000992289203100703 |
| format | Article |
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(Pennsylvania State University, Hershey) ; Berlin, C.M. Jr</creator><creatorcontrib>Mackey, S.A. (Pennsylvania State University, Hershey) ; Berlin, C.M. Jr</creatorcontrib><description>Six normal subjects each ingested a single 12 ounce can of a diet cola (Diet Coke) providing 184 mg aspartame (APM), of which 104 mg is phenylalanine (Phe), and, on another occasion, a single 12 ounce can of regular cola (Coke Classic). Neither cola significantly affected plasma concentrations of Phe or tyrosine over the three-hour postingestion study period. Each of five homozygous phenylketonuric (PKU) subjects (ages 11, 16, 17, 21, and 23 years) ingested a single 12 ounce can of the same diet cola. In these five subjects (three with classic PKU and two with hyperphenylalinemia), the increase in plasma Phe concentrations varied from 0.26 mg/dL to 1.77 mg/dL two or three hours after ingestion (baseline levels, 5.04 to 17.2 mg/dL). Tyrosine concentrations did not differ significantly from baseline levels. The data indicate that ingestion of dietary Phe, as supplied in a single can of diet cola, is readily handled in both normal and PKU subjects. The small increases in plasma Phe concentrations in the homozygous PKU patients are not considered clinically significant</description><identifier>ISSN: 0009-9228</identifier><identifier>EISSN: 1938-2707</identifier><identifier>DOI: 10.1177/000992289203100703</identifier><identifier>PMID: 1617863</identifier><identifier>CODEN: CPEDAM</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adolescent ; Adult ; Aminoacid disorders ; ASPARTAME ; Aspartame - administration & dosage ; Aspartame - pharmacology ; ASPARTAMO ; BEBIDAS ; Biological and medical sciences ; Body Weight ; BOISSON ; Child ; ENFANT ; Errors of metabolism ; Female ; FENILALANINA ; Homozygote ; Humans ; Life Sciences & Biomedicine ; Male ; Medical sciences ; Metabolic diseases ; NINOS ; Pediatrics ; PHENYLALANINE ; Phenylalanine - blood ; Phenylalanine - drug effects ; Phenylketonurias - blood ; Phenylketonurias - diet therapy ; Phenylketonurias - genetics ; PLASMA SANGUIN ; PLASMA SANGUINEO ; Science & Technology ; Sweetening Agents - administration & dosage ; Sweetening Agents - pharmacology ; TIROSINA ; TRASTORNOS METABOLICOS ; TROUBLE DU METABOLISME ; TYROSINE ; Tyrosine - blood ; Tyrosine - drug effects</subject><ispartof>Clinical pediatrics, 1992-07, Vol.31 (7), p.394-399</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>14</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992JE32500003</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c386t-c73c6d6592cb5f0a4635ff07efcbd9f402bbec1af71e29e9340cd7d27bf0b853</citedby><cites>FETCH-LOGICAL-c386t-c73c6d6592cb5f0a4635ff07efcbd9f402bbec1af71e29e9340cd7d27bf0b853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000992289203100703$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000992289203100703$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27197,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5450236$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1617863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mackey, S.A. (Pennsylvania State University, Hershey)</creatorcontrib><creatorcontrib>Berlin, C.M. Jr</creatorcontrib><title>Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenylketonuric patients</title><title>Clinical pediatrics</title><addtitle>CLIN PEDIATR</addtitle><addtitle>Clin Pediatr (Phila)</addtitle><description>Six normal subjects each ingested a single 12 ounce can of a diet cola (Diet Coke) providing 184 mg aspartame (APM), of which 104 mg is phenylalanine (Phe), and, on another occasion, a single 12 ounce can of regular cola (Coke Classic). Neither cola significantly affected plasma concentrations of Phe or tyrosine over the three-hour postingestion study period. Each of five homozygous phenylketonuric (PKU) subjects (ages 11, 16, 17, 21, and 23 years) ingested a single 12 ounce can of the same diet cola. In these five subjects (three with classic PKU and two with hyperphenylalinemia), the increase in plasma Phe concentrations varied from 0.26 mg/dL to 1.77 mg/dL two or three hours after ingestion (baseline levels, 5.04 to 17.2 mg/dL). Tyrosine concentrations did not differ significantly from baseline levels. The data indicate that ingestion of dietary Phe, as supplied in a single can of diet cola, is readily handled in both normal and PKU subjects. The small increases in plasma Phe concentrations in the homozygous PKU patients are not considered clinically significant</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aminoacid disorders</subject><subject>ASPARTAME</subject><subject>Aspartame - administration & dosage</subject><subject>Aspartame - pharmacology</subject><subject>ASPARTAMO</subject><subject>BEBIDAS</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>BOISSON</subject><subject>Child</subject><subject>ENFANT</subject><subject>Errors of metabolism</subject><subject>Female</subject><subject>FENILALANINA</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>NINOS</subject><subject>Pediatrics</subject><subject>PHENYLALANINE</subject><subject>Phenylalanine - blood</subject><subject>Phenylalanine - drug effects</subject><subject>Phenylketonurias - blood</subject><subject>Phenylketonurias - diet therapy</subject><subject>Phenylketonurias - genetics</subject><subject>PLASMA SANGUIN</subject><subject>PLASMA SANGUINEO</subject><subject>Science & Technology</subject><subject>Sweetening Agents - administration & dosage</subject><subject>Sweetening Agents - pharmacology</subject><subject>TIROSINA</subject><subject>TRASTORNOS METABOLICOS</subject><subject>TROUBLE DU METABOLISME</subject><subject>TYROSINE</subject><subject>Tyrosine - blood</subject><subject>Tyrosine - drug effects</subject><issn>0009-9228</issn><issn>1938-2707</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkk9v1DAQxSMEKkvhC1RC8gFxQaFjexMnx2q1_FMlDpRzNHHG25TEDrYjtJz54DjNqhyQECfLnt8bv3l2ll1weMu5UpcAUNdCVLUAyQEUyEfZhteyyoUC9TjbLEC-EE-zZyHcAXAJhTzLznjJVVXKTfZrbwzpyJxhXU8R_ZFhmNBHHIk5y6YBw4hMO6vJRo-xdzYs9HRL9jjggLa3xNB2LB69C8umt8w6P-Jwf3zrRvfzeHBzOGm-UXR29r1mU2qXuobn2RODQ6AXp_U8u3m3v9l9yK8_v_-4u7rOtazKmGslddmVRS10WxjAbSkLY0CR0W1Xmy2ItiXN0ShOoqZabkF3qhOqNdBWhTzPXq9tJ---zxRiM_ZB05BmoGSvURJksYUFFCuo00TBk2km348pm4ZDsyTf_J18Er08dZ_bkbo_kjXqVH91qmPQOBiPVvfhASu2BQhZJqxasR_UOhN0CkjTA3XF07Wf9lIUyQHIXR_vX2TnZhuT9M3_SxN9udIBD9TcudnblP2_J7xYFQZdgwef3H_9UqcfxZPz32bZxYQ</recordid><startdate>19920701</startdate><enddate>19920701</enddate><creator>Mackey, S.A. (Pennsylvania State University, Hershey)</creator><creator>Berlin, C.M. Jr</creator><general>SAGE Publications</general><general>Westminster Publ Inc</general><general>Westminster</general><scope>FBQ</scope><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920701</creationdate><title>Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenylketonuric patients</title><author>Mackey, S.A. (Pennsylvania State University, Hershey) ; Berlin, C.M. Jr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-c73c6d6592cb5f0a4635ff07efcbd9f402bbec1af71e29e9340cd7d27bf0b853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aminoacid disorders</topic><topic>ASPARTAME</topic><topic>Aspartame - administration & dosage</topic><topic>Aspartame - pharmacology</topic><topic>ASPARTAMO</topic><topic>BEBIDAS</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>BOISSON</topic><topic>Child</topic><topic>ENFANT</topic><topic>Errors of metabolism</topic><topic>Female</topic><topic>FENILALANINA</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>NINOS</topic><topic>Pediatrics</topic><topic>PHENYLALANINE</topic><topic>Phenylalanine - blood</topic><topic>Phenylalanine - drug effects</topic><topic>Phenylketonurias - blood</topic><topic>Phenylketonurias - diet therapy</topic><topic>Phenylketonurias - genetics</topic><topic>PLASMA SANGUIN</topic><topic>PLASMA SANGUINEO</topic><topic>Science & Technology</topic><topic>Sweetening Agents - administration & dosage</topic><topic>Sweetening Agents - pharmacology</topic><topic>TIROSINA</topic><topic>TRASTORNOS METABOLICOS</topic><topic>TROUBLE DU METABOLISME</topic><topic>TYROSINE</topic><topic>Tyrosine - blood</topic><topic>Tyrosine - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mackey, S.A. (Pennsylvania State University, Hershey)</creatorcontrib><creatorcontrib>Berlin, C.M. Jr</creatorcontrib><collection>AGRIS</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mackey, S.A. (Pennsylvania State University, Hershey)</au><au>Berlin, C.M. Jr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenylketonuric patients</atitle><jtitle>Clinical pediatrics</jtitle><stitle>CLIN PEDIATR</stitle><addtitle>Clin Pediatr (Phila)</addtitle><date>1992-07-01</date><risdate>1992</risdate><volume>31</volume><issue>7</issue><spage>394</spage><epage>399</epage><pages>394-399</pages><issn>0009-9228</issn><eissn>1938-2707</eissn><coden>CPEDAM</coden><abstract>Six normal subjects each ingested a single 12 ounce can of a diet cola (Diet Coke) providing 184 mg aspartame (APM), of which 104 mg is phenylalanine (Phe), and, on another occasion, a single 12 ounce can of regular cola (Coke Classic). Neither cola significantly affected plasma concentrations of Phe or tyrosine over the three-hour postingestion study period. Each of five homozygous phenylketonuric (PKU) subjects (ages 11, 16, 17, 21, and 23 years) ingested a single 12 ounce can of the same diet cola. In these five subjects (three with classic PKU and two with hyperphenylalinemia), the increase in plasma Phe concentrations varied from 0.26 mg/dL to 1.77 mg/dL two or three hours after ingestion (baseline levels, 5.04 to 17.2 mg/dL). Tyrosine concentrations did not differ significantly from baseline levels. The data indicate that ingestion of dietary Phe, as supplied in a single can of diet cola, is readily handled in both normal and PKU subjects. The small increases in plasma Phe concentrations in the homozygous PKU patients are not considered clinically significant</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>1617863</pmid><doi>10.1177/000992289203100703</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9228 |
| ispartof | Clinical pediatrics, 1992-07, Vol.31 (7), p.394-399 |
| issn | 0009-9228 1938-2707 |
| language | eng |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Access via SAGE; MEDLINE |
| subjects | Adolescent Adult Aminoacid disorders ASPARTAME Aspartame - administration & dosage Aspartame - pharmacology ASPARTAMO BEBIDAS Biological and medical sciences Body Weight BOISSON Child ENFANT Errors of metabolism Female FENILALANINA Homozygote Humans Life Sciences & Biomedicine Male Medical sciences Metabolic diseases NINOS Pediatrics PHENYLALANINE Phenylalanine - blood Phenylalanine - drug effects Phenylketonurias - blood Phenylketonurias - diet therapy Phenylketonurias - genetics PLASMA SANGUIN PLASMA SANGUINEO Science & Technology Sweetening Agents - administration & dosage Sweetening Agents - pharmacology TIROSINA TRASTORNOS METABOLICOS TROUBLE DU METABOLISME TYROSINE Tyrosine - blood Tyrosine - drug effects |
| title | Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenylketonuric patients |
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