Cushing's Syndrome and Hypothalamic-Pituitary Adrenal Axis Suppression Induced by Medroxyprogesterone Acetate
The referral of a patient with features of Cushing's syndrome but with suppressed plasma cortisol and adrenocorticotrophic hormone concentrations prompted us to study the effect of medroxyprogesterone acetate (MPA) therapy on the adrenal axis. 11 women (aged 54–82 years) who were receiving 200–...
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| Veröffentlicht in: | Annals of clinical biochemistry 1996-05, Vol.33 (3), p.187-189 |
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| container_end_page | 189 |
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| container_issue | 3 |
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| container_title | Annals of clinical biochemistry |
| container_volume | 33 |
| creator | Malik, K J Wakelin, K Dean, S Cove, D H Wood, P J |
| description | The referral of a patient with features of Cushing's syndrome but with suppressed plasma cortisol and adrenocorticotrophic hormone concentrations prompted us to study the effect of medroxyprogesterone acetate (MPA) therapy on the adrenal axis. 11 women (aged 54–82 years) who were receiving 200–400 mg/day MPA were studied. Of these, four had subnormal plasma cortisol responses to a short synacthen test, and two more had borderline responses (30 min post-synacthen plasma cortisol results of 411 and 511 nmol/L). We conclude that suppression of the adrenal axis occurs relatively frequently in patients on MPA and that such patients should be checked for evidence of suppression before MPA therapy is withdrawn. |
| doi_str_mv | 10.1177/000456329603300302 |
| format | Article |
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Of these, four had subnormal plasma cortisol responses to a short synacthen test, and two more had borderline responses (30 min post-synacthen plasma cortisol results of 411 and 511 nmol/L). We conclude that suppression of the adrenal axis occurs relatively frequently in patients on MPA and that such patients should be checked for evidence of suppression before MPA therapy is withdrawn.</description><identifier>ISSN: 0004-5632</identifier><identifier>EISSN: 1758-1001</identifier><identifier>DOI: 10.1177/000456329603300302</identifier><identifier>PMID: 8791979</identifier><identifier>CODEN: ACBOBU</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Aged, 80 and over ; Antineoplastic Agents, Hormonal - adverse effects ; Biological and medical sciences ; Cushing Syndrome - chemically induced ; Depression, Chemical ; Drug toxicity and drugs side effects treatment ; Female ; Humans ; Hypothalamo-Hypophyseal System - drug effects ; Medical sciences ; Medroxyprogesterone Acetate - adverse effects ; Middle Aged ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. 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Of these, four had subnormal plasma cortisol responses to a short synacthen test, and two more had borderline responses (30 min post-synacthen plasma cortisol results of 411 and 511 nmol/L). We conclude that suppression of the adrenal axis occurs relatively frequently in patients on MPA and that such patients should be checked for evidence of suppression before MPA therapy is withdrawn.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Agents, Hormonal - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Cushing Syndrome - chemically induced</subject><subject>Depression, Chemical</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Medical sciences</subject><subject>Medroxyprogesterone Acetate - adverse effects</subject><subject>Middle Aged</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. Drug treatments</subject><subject>Pituitary-Adrenal System - drug effects</subject><issn>0004-5632</issn><issn>1758-1001</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9Lw0AQxRdRaq1-AUHYg-Apdja7m2SPpagtVBTUc9hsJm1K84fdBJpv75aWXgRPw_B-7w3zCLln8MxYHE8BQMiIhyoCzgE4hBdkzGKZBAyAXZLxAQgOxDW5cW7r1zAGGJFREiumYjUm1bx3m7JePzn6NdS5bSqkus7pYmibbqN3uipN8Fl2fdlpO9BZbrHWOzrbl97Qt61F58qmpss67w3mNBvoO_qY_dDaZo2uQ9vUSGcGO93hLbkq9M7h3WlOyM_ry_d8Eaw-3pbz2SowgrEu0FGmIVKhygQKLSLJZRJHSsgi5EoLgYCRNDGqnKko51wakJ5IMEGUItN8QsJjrrGNcxaLtLVl5R9IGaSH6tK_1XnTw9HU9lmF-dly6srrjyddO6N3hdW1Kd0Z4wzCUDKPTY-Y02tMt01vfWHuv8O_ioGEFA</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>Malik, K J</creator><creator>Wakelin, K</creator><creator>Dean, S</creator><creator>Cove, D H</creator><creator>Wood, P J</creator><general>SAGE Publications</general><general>Royal Society of Medicine Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19960501</creationdate><title>Cushing's Syndrome and Hypothalamic-Pituitary Adrenal Axis Suppression Induced by Medroxyprogesterone Acetate</title><author>Malik, K J ; Wakelin, K ; Dean, S ; Cove, D H ; Wood, P J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-a6ba06929b4e4a46535876945f239a44e0e65c7e9d196d335c055878e8ee54ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Agents, Hormonal - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Cushing Syndrome - chemically induced</topic><topic>Depression, Chemical</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Medical sciences</topic><topic>Medroxyprogesterone Acetate - adverse effects</topic><topic>Middle Aged</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Pharmacology. Drug treatments</topic><topic>Pituitary-Adrenal System - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malik, K J</creatorcontrib><creatorcontrib>Wakelin, K</creatorcontrib><creatorcontrib>Dean, S</creatorcontrib><creatorcontrib>Cove, D H</creatorcontrib><creatorcontrib>Wood, P J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Annals of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malik, K J</au><au>Wakelin, K</au><au>Dean, S</au><au>Cove, D H</au><au>Wood, P J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cushing's Syndrome and Hypothalamic-Pituitary Adrenal Axis Suppression Induced by Medroxyprogesterone Acetate</atitle><jtitle>Annals of clinical biochemistry</jtitle><addtitle>Ann Clin Biochem</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>33</volume><issue>3</issue><spage>187</spage><epage>189</epage><pages>187-189</pages><issn>0004-5632</issn><eissn>1758-1001</eissn><coden>ACBOBU</coden><abstract>The referral of a patient with features of Cushing's syndrome but with suppressed plasma cortisol and adrenocorticotrophic hormone concentrations prompted us to study the effect of medroxyprogesterone acetate (MPA) therapy on the adrenal axis. 11 women (aged 54–82 years) who were receiving 200–400 mg/day MPA were studied. Of these, four had subnormal plasma cortisol responses to a short synacthen test, and two more had borderline responses (30 min post-synacthen plasma cortisol results of 411 and 511 nmol/L). We conclude that suppression of the adrenal axis occurs relatively frequently in patients on MPA and that such patients should be checked for evidence of suppression before MPA therapy is withdrawn.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>8791979</pmid><doi>10.1177/000456329603300302</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of clinical biochemistry, 1996-05, Vol.33 (3), p.187-189 |
| issn | 0004-5632 1758-1001 |
| language | eng |
| recordid | cdi_crossref_primary_10_1177_000456329603300302 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Antineoplastic Agents, Hormonal - adverse effects Biological and medical sciences Cushing Syndrome - chemically induced Depression, Chemical Drug toxicity and drugs side effects treatment Female Humans Hypothalamo-Hypophyseal System - drug effects Medical sciences Medroxyprogesterone Acetate - adverse effects Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Pituitary-Adrenal System - drug effects |
| title | Cushing's Syndrome and Hypothalamic-Pituitary Adrenal Axis Suppression Induced by Medroxyprogesterone Acetate |
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