Experimental Inhibition of Protamine Cardiotoxicity by Prostacyclin
Twelve animals (26 ± 5 kg) were subjected to the study. In this experimental study, the authors used prostacyclin to inhibit the toxic metabolite release during protamine admin istration. Animals were divided into two equal groups. Six animals received prostacyclin (the prostacyclin group), and the...
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| Veröffentlicht in: | Angiology 1999-11, Vol.50 (11), p.929-935 |
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| creator | Fehmi Katircioğlu, S. Ulus, Tulga Yamak, Birol Saritaş, Zülfikar Yildiz, Ülkü |
| description | Twelve animals (26 ± 5 kg) were subjected to the study. In this experimental study, the authors used prostacyclin to inhibit the toxic metabolite release during protamine admin istration. Animals were divided into two equal groups. Six animals received prostacyclin (the prostacyclin group), and the other six animals did not receive any additional treatment (the control group).
All cardiac output and biochemical measurements were evaluated at baseline; before cardiopulmonary bypass; and at 5, 30, and 60 minutes after protamine administration. The measured cardiac index showed that the hearts treated with prostacyclin had satis factory preservation of left ventricular function.
Metabolic and biochemical data showed that the tumor necrosis factor level was raised significantly in the control group (20.75 ± 2.2 in the control group and 13.75 ± 2.5 pg/mL in the prostacyclin group). Also, E and P selectin levels were elevated in the control group, but this change was less marked in the prostacyclin group. In addition, the intracellular adhesion molecule-1 (ICAM-1) level was significantly higher in the control group than in the prostacyclin group (9.26 ±2.13 in the control group and 5.13 ± 1.66 ng/mL in the prostacyclin group).
The authors observed that prostacyclin inhibited the toxic mediator release during heparin reversal with protamine. This inhibition is one way of protecting the myocardium reserves from protamine cardiotoxicity. |
| doi_str_mv | 10.1177/000331979905001108 |
| format | Article |
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All cardiac output and biochemical measurements were evaluated at baseline; before cardiopulmonary bypass; and at 5, 30, and 60 minutes after protamine administration. The measured cardiac index showed that the hearts treated with prostacyclin had satis factory preservation of left ventricular function.
Metabolic and biochemical data showed that the tumor necrosis factor level was raised significantly in the control group (20.75 ± 2.2 in the control group and 13.75 ± 2.5 pg/mL in the prostacyclin group). Also, E and P selectin levels were elevated in the control group, but this change was less marked in the prostacyclin group. In addition, the intracellular adhesion molecule-1 (ICAM-1) level was significantly higher in the control group than in the prostacyclin group (9.26 ±2.13 in the control group and 5.13 ± 1.66 ng/mL in the prostacyclin group).
The authors observed that prostacyclin inhibited the toxic mediator release during heparin reversal with protamine. This inhibition is one way of protecting the myocardium reserves from protamine cardiotoxicity.</description><identifier>ISSN: 0003-3197</identifier><identifier>EISSN: 1940-1574</identifier><identifier>DOI: 10.1177/000331979905001108</identifier><identifier>PMID: 10580358</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Animals ; Dogs ; E-Selectin - metabolism ; Enzyme-Linked Immunosorbent Assay ; Epoprostenol - pharmacology ; Heart - drug effects ; Heparin Antagonists - toxicity ; Intercellular Adhesion Molecule-1 - metabolism ; P-Selectin - metabolism ; Platelet Aggregation Inhibitors - pharmacology ; Protamines - antagonists & inhibitors ; Protamines - toxicity ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Angiology, 1999-11, Vol.50 (11), p.929-935</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-d2864dbfd12a6f21138116be5e869aca3f722030cac194a6d50a317399c4f1513</citedby><cites>FETCH-LOGICAL-c339t-d2864dbfd12a6f21138116be5e869aca3f722030cac194a6d50a317399c4f1513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000331979905001108$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000331979905001108$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10580358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fehmi Katircioğlu, S.</creatorcontrib><creatorcontrib>Ulus, Tulga</creatorcontrib><creatorcontrib>Yamak, Birol</creatorcontrib><creatorcontrib>Saritaş, Zülfikar</creatorcontrib><creatorcontrib>Yildiz, Ülkü</creatorcontrib><title>Experimental Inhibition of Protamine Cardiotoxicity by Prostacyclin</title><title>Angiology</title><addtitle>Angiology</addtitle><description>Twelve animals (26 ± 5 kg) were subjected to the study. In this experimental study, the authors used prostacyclin to inhibit the toxic metabolite release during protamine admin istration. Animals were divided into two equal groups. Six animals received prostacyclin (the prostacyclin group), and the other six animals did not receive any additional treatment (the control group).
All cardiac output and biochemical measurements were evaluated at baseline; before cardiopulmonary bypass; and at 5, 30, and 60 minutes after protamine administration. The measured cardiac index showed that the hearts treated with prostacyclin had satis factory preservation of left ventricular function.
Metabolic and biochemical data showed that the tumor necrosis factor level was raised significantly in the control group (20.75 ± 2.2 in the control group and 13.75 ± 2.5 pg/mL in the prostacyclin group). Also, E and P selectin levels were elevated in the control group, but this change was less marked in the prostacyclin group. In addition, the intracellular adhesion molecule-1 (ICAM-1) level was significantly higher in the control group than in the prostacyclin group (9.26 ±2.13 in the control group and 5.13 ± 1.66 ng/mL in the prostacyclin group).
The authors observed that prostacyclin inhibited the toxic mediator release during heparin reversal with protamine. This inhibition is one way of protecting the myocardium reserves from protamine cardiotoxicity.</description><subject>Animals</subject><subject>Dogs</subject><subject>E-Selectin - metabolism</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epoprostenol - pharmacology</subject><subject>Heart - drug effects</subject><subject>Heparin Antagonists - toxicity</subject><subject>Intercellular Adhesion Molecule-1 - metabolism</subject><subject>P-Selectin - metabolism</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Protamines - antagonists & inhibitors</subject><subject>Protamines - toxicity</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0003-3197</issn><issn>1940-1574</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFKw0AQhhdRbKy-gAfJC8TOZLNJ9iih1kJBD3oOk82ubmmTkGyheXs3xIMgeBqG-f6Z-X_G7hEeEbNsBQCco8ykBAGACPkFC1AmEKHIkksWTEA0EQt2Mwx73wqE9JotEEQOXOQBK9bnTvf2qBtHh3DbfNnKOts2YWvCt751dLSNDgvqa9u69myVdWNYjdNscKRGdbDNLbsydBj03U9dso_n9XvxEu1eN9viaRcpzqWL6jhPk7oyNcaUmhiR54hppYXOU0mKuMniGDgoUt4EpbUA4phxKVViUCBfsnjeq_zxodem7Pzn1I8lQjklUv5NxIseZlF3qo66_iWZI_DAagYG-tTlvj31jTfx38pvpbdonQ</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Fehmi Katircioğlu, S.</creator><creator>Ulus, Tulga</creator><creator>Yamak, Birol</creator><creator>Saritaş, Zülfikar</creator><creator>Yildiz, Ülkü</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19991101</creationdate><title>Experimental Inhibition of Protamine Cardiotoxicity by Prostacyclin</title><author>Fehmi Katircioğlu, S. ; Ulus, Tulga ; Yamak, Birol ; Saritaş, Zülfikar ; Yildiz, Ülkü</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-d2864dbfd12a6f21138116be5e869aca3f722030cac194a6d50a317399c4f1513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Dogs</topic><topic>E-Selectin - metabolism</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Epoprostenol - pharmacology</topic><topic>Heart - drug effects</topic><topic>Heparin Antagonists - toxicity</topic><topic>Intercellular Adhesion Molecule-1 - metabolism</topic><topic>P-Selectin - metabolism</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Protamines - antagonists & inhibitors</topic><topic>Protamines - toxicity</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fehmi Katircioğlu, S.</creatorcontrib><creatorcontrib>Ulus, Tulga</creatorcontrib><creatorcontrib>Yamak, Birol</creatorcontrib><creatorcontrib>Saritaş, Zülfikar</creatorcontrib><creatorcontrib>Yildiz, Ülkü</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Angiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fehmi Katircioğlu, S.</au><au>Ulus, Tulga</au><au>Yamak, Birol</au><au>Saritaş, Zülfikar</au><au>Yildiz, Ülkü</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Inhibition of Protamine Cardiotoxicity by Prostacyclin</atitle><jtitle>Angiology</jtitle><addtitle>Angiology</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>50</volume><issue>11</issue><spage>929</spage><epage>935</epage><pages>929-935</pages><issn>0003-3197</issn><eissn>1940-1574</eissn><abstract>Twelve animals (26 ± 5 kg) were subjected to the study. In this experimental study, the authors used prostacyclin to inhibit the toxic metabolite release during protamine admin istration. Animals were divided into two equal groups. Six animals received prostacyclin (the prostacyclin group), and the other six animals did not receive any additional treatment (the control group).
All cardiac output and biochemical measurements were evaluated at baseline; before cardiopulmonary bypass; and at 5, 30, and 60 minutes after protamine administration. The measured cardiac index showed that the hearts treated with prostacyclin had satis factory preservation of left ventricular function.
Metabolic and biochemical data showed that the tumor necrosis factor level was raised significantly in the control group (20.75 ± 2.2 in the control group and 13.75 ± 2.5 pg/mL in the prostacyclin group). Also, E and P selectin levels were elevated in the control group, but this change was less marked in the prostacyclin group. In addition, the intracellular adhesion molecule-1 (ICAM-1) level was significantly higher in the control group than in the prostacyclin group (9.26 ±2.13 in the control group and 5.13 ± 1.66 ng/mL in the prostacyclin group).
The authors observed that prostacyclin inhibited the toxic mediator release during heparin reversal with protamine. This inhibition is one way of protecting the myocardium reserves from protamine cardiotoxicity.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>10580358</pmid><doi>10.1177/000331979905001108</doi><tpages>7</tpages></addata></record> |
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| ispartof | Angiology, 1999-11, Vol.50 (11), p.929-935 |
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| source | Access via SAGE; MEDLINE |
| subjects | Animals Dogs E-Selectin - metabolism Enzyme-Linked Immunosorbent Assay Epoprostenol - pharmacology Heart - drug effects Heparin Antagonists - toxicity Intercellular Adhesion Molecule-1 - metabolism P-Selectin - metabolism Platelet Aggregation Inhibitors - pharmacology Protamines - antagonists & inhibitors Protamines - toxicity Tumor Necrosis Factor-alpha - metabolism |
| title | Experimental Inhibition of Protamine Cardiotoxicity by Prostacyclin |
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