Glaucoma-Diagnostic Ability of Ganglion Cell-Inner Plexiform Layer Thickness Difference Across Temporal Raphe in Highly Myopic Eyes
To evaluate the glaucoma-diagnostic ability of the ganglion cell-inner plexiform layer (GCIPL) thickness difference across the temporal raphe in highly myopic eyes. We consecutively enrolled a total of 195 highly myopic eyes (axial length [AL] >26.5 mm) of 195 subjects: 93 glaucoma patients along...
Gespeichert in:
| Veröffentlicht in: | Investigative ophthalmology & visual science 2016-11, Vol.57 (14), p.5856 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 14 |
| container_start_page | 5856 |
| container_title | Investigative ophthalmology & visual science |
| container_volume | 57 |
| creator | Kim, Young Kook Yoo, Byeong Wook Jeoung, Jin Wook Kim, Hee Chan Kim, Hae Jin Park, Ki Ho |
| description | To evaluate the glaucoma-diagnostic ability of the ganglion cell-inner plexiform layer (GCIPL) thickness difference across the temporal raphe in highly myopic eyes.
We consecutively enrolled a total of 195 highly myopic eyes (axial length [AL] >26.5 mm) of 195 subjects: 93 glaucoma patients along with and 102 nonglaucomatous subjects. Cirrus high-definition optical coherence tomography (OCT) was employed to scan all of the subjects' macular and optic discs. Using a MATLAB-based customized program (the GCIPL hemifield test), a positive test result was automatically declared if the following two conditions were met: (1) the horizontal line is detected for longer than one-half of the distance from the temporal inner elliptical annulus to the outer elliptical annulus, and (2) the average GCIPL thickness difference within 10 pixels of the reference line, both above and below, is 5 μm or more. The glaucoma-diagnostic ability was computed using the area under the receiver operating characteristic curve (AUC).
Among the glaucomatous eyes, GCIPL hemifield test positivity was shown in 92.5% (86 of 93), significantly higher than that for the nonglaucomatous eyes (4.90%, 5 of 102; P |
| doi_str_mv | 10.1167/iovs.16-20116 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1167_iovs_16_20116</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>27802515</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-45d2b33813bff2d671d372be0454c77be2b11801a615fe5686f7b0a3d6c93b3f3</originalsourceid><addsrcrecordid>eNpNkE1PAjEQhhujUfw4ejX9A4v9oNvlSACBBKMxeN603Raq3XbTgnHP_nEXUONp5p08mZk8ANxi1Mc45_c2fKQ-zjOCungCepgxkjFe0NN__QW4TOkNIYIxQefggvACEYZZD3zNnNipUItsYsXah7S1Co6kdXbbwmDgTPi1s8HDsXYuW3ivI3x2-tOaEGu4FG2XVxur3r1OCU6sMTpqrzQcqRi6yUrXTYjCwRfRbDS0Hs7teuNa-NiGpjs1bXW6BmdGuKRvfuoVeH2YrsbzbPk0W4xHy0zRYbHNBqwiktICU2kMqXKOK8qJ1GjABopzqYnEuEBY5JgZzfIiN1wiQatcDamkhl6B7Lj38FrUpmyirUVsS4zKvcxyL7PEeXmQ2fF3R77ZyVpXf_SvPfoNV1Vx8Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Glaucoma-Diagnostic Ability of Ganglion Cell-Inner Plexiform Layer Thickness Difference Across Temporal Raphe in Highly Myopic Eyes</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Kim, Young Kook ; Yoo, Byeong Wook ; Jeoung, Jin Wook ; Kim, Hee Chan ; Kim, Hae Jin ; Park, Ki Ho</creator><creatorcontrib>Kim, Young Kook ; Yoo, Byeong Wook ; Jeoung, Jin Wook ; Kim, Hee Chan ; Kim, Hae Jin ; Park, Ki Ho</creatorcontrib><description>To evaluate the glaucoma-diagnostic ability of the ganglion cell-inner plexiform layer (GCIPL) thickness difference across the temporal raphe in highly myopic eyes.
We consecutively enrolled a total of 195 highly myopic eyes (axial length [AL] >26.5 mm) of 195 subjects: 93 glaucoma patients along with and 102 nonglaucomatous subjects. Cirrus high-definition optical coherence tomography (OCT) was employed to scan all of the subjects' macular and optic discs. Using a MATLAB-based customized program (the GCIPL hemifield test), a positive test result was automatically declared if the following two conditions were met: (1) the horizontal line is detected for longer than one-half of the distance from the temporal inner elliptical annulus to the outer elliptical annulus, and (2) the average GCIPL thickness difference within 10 pixels of the reference line, both above and below, is 5 μm or more. The glaucoma-diagnostic ability was computed using the area under the receiver operating characteristic curve (AUC).
Among the glaucomatous eyes, GCIPL hemifield test positivity was shown in 92.5% (86 of 93), significantly higher than that for the nonglaucomatous eyes (4.90%, 5 of 102; P <0.001). The value of AUC for the GCIPL hemifield test was excellent (0.938; sensitivity 92.50%, specificity 95.10%) and was the best compared with those for any of OCT parameters.
In highly myopic eyes, determination of the presence or absence of GCIPL thickness difference across the temporal raphe via OCT macula scan can be a useful means of distinguishing the glaucomatous damage.</description><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.16-20116</identifier><identifier>PMID: 27802515</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Area Under Curve ; Case-Control Studies ; Female ; Glaucoma - diagnosis ; Glaucoma - physiopathology ; Humans ; Male ; Middle Aged ; Myopia, Degenerative - pathology ; Nerve Fibers ; Optic Disk - pathology ; Optic Nerve Diseases - pathology ; Retinal Ganglion Cells - pathology ; Tomography, Optical Coherence - methods ; Visual Fields - physiology</subject><ispartof>Investigative ophthalmology & visual science, 2016-11, Vol.57 (14), p.5856</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-45d2b33813bff2d671d372be0454c77be2b11801a615fe5686f7b0a3d6c93b3f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27802515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Young Kook</creatorcontrib><creatorcontrib>Yoo, Byeong Wook</creatorcontrib><creatorcontrib>Jeoung, Jin Wook</creatorcontrib><creatorcontrib>Kim, Hee Chan</creatorcontrib><creatorcontrib>Kim, Hae Jin</creatorcontrib><creatorcontrib>Park, Ki Ho</creatorcontrib><title>Glaucoma-Diagnostic Ability of Ganglion Cell-Inner Plexiform Layer Thickness Difference Across Temporal Raphe in Highly Myopic Eyes</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To evaluate the glaucoma-diagnostic ability of the ganglion cell-inner plexiform layer (GCIPL) thickness difference across the temporal raphe in highly myopic eyes.
We consecutively enrolled a total of 195 highly myopic eyes (axial length [AL] >26.5 mm) of 195 subjects: 93 glaucoma patients along with and 102 nonglaucomatous subjects. Cirrus high-definition optical coherence tomography (OCT) was employed to scan all of the subjects' macular and optic discs. Using a MATLAB-based customized program (the GCIPL hemifield test), a positive test result was automatically declared if the following two conditions were met: (1) the horizontal line is detected for longer than one-half of the distance from the temporal inner elliptical annulus to the outer elliptical annulus, and (2) the average GCIPL thickness difference within 10 pixels of the reference line, both above and below, is 5 μm or more. The glaucoma-diagnostic ability was computed using the area under the receiver operating characteristic curve (AUC).
Among the glaucomatous eyes, GCIPL hemifield test positivity was shown in 92.5% (86 of 93), significantly higher than that for the nonglaucomatous eyes (4.90%, 5 of 102; P <0.001). The value of AUC for the GCIPL hemifield test was excellent (0.938; sensitivity 92.50%, specificity 95.10%) and was the best compared with those for any of OCT parameters.
In highly myopic eyes, determination of the presence or absence of GCIPL thickness difference across the temporal raphe via OCT macula scan can be a useful means of distinguishing the glaucomatous damage.</description><subject>Adult</subject><subject>Aged</subject><subject>Area Under Curve</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Glaucoma - diagnosis</subject><subject>Glaucoma - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myopia, Degenerative - pathology</subject><subject>Nerve Fibers</subject><subject>Optic Disk - pathology</subject><subject>Optic Nerve Diseases - pathology</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Visual Fields - physiology</subject><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1PAjEQhhujUfw4ejX9A4v9oNvlSACBBKMxeN603Raq3XbTgnHP_nEXUONp5p08mZk8ANxi1Mc45_c2fKQ-zjOCungCepgxkjFe0NN__QW4TOkNIYIxQefggvACEYZZD3zNnNipUItsYsXah7S1Co6kdXbbwmDgTPi1s8HDsXYuW3ivI3x2-tOaEGu4FG2XVxur3r1OCU6sMTpqrzQcqRi6yUrXTYjCwRfRbDS0Hs7teuNa-NiGpjs1bXW6BmdGuKRvfuoVeH2YrsbzbPk0W4xHy0zRYbHNBqwiktICU2kMqXKOK8qJ1GjABopzqYnEuEBY5JgZzfIiN1wiQatcDamkhl6B7Lj38FrUpmyirUVsS4zKvcxyL7PEeXmQ2fF3R77ZyVpXf_SvPfoNV1Vx8Q</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Kim, Young Kook</creator><creator>Yoo, Byeong Wook</creator><creator>Jeoung, Jin Wook</creator><creator>Kim, Hee Chan</creator><creator>Kim, Hae Jin</creator><creator>Park, Ki Ho</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20161101</creationdate><title>Glaucoma-Diagnostic Ability of Ganglion Cell-Inner Plexiform Layer Thickness Difference Across Temporal Raphe in Highly Myopic Eyes</title><author>Kim, Young Kook ; Yoo, Byeong Wook ; Jeoung, Jin Wook ; Kim, Hee Chan ; Kim, Hae Jin ; Park, Ki Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-45d2b33813bff2d671d372be0454c77be2b11801a615fe5686f7b0a3d6c93b3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Area Under Curve</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Glaucoma - diagnosis</topic><topic>Glaucoma - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myopia, Degenerative - pathology</topic><topic>Nerve Fibers</topic><topic>Optic Disk - pathology</topic><topic>Optic Nerve Diseases - pathology</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Visual Fields - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Young Kook</creatorcontrib><creatorcontrib>Yoo, Byeong Wook</creatorcontrib><creatorcontrib>Jeoung, Jin Wook</creatorcontrib><creatorcontrib>Kim, Hee Chan</creatorcontrib><creatorcontrib>Kim, Hae Jin</creatorcontrib><creatorcontrib>Park, Ki Ho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Young Kook</au><au>Yoo, Byeong Wook</au><au>Jeoung, Jin Wook</au><au>Kim, Hee Chan</au><au>Kim, Hae Jin</au><au>Park, Ki Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glaucoma-Diagnostic Ability of Ganglion Cell-Inner Plexiform Layer Thickness Difference Across Temporal Raphe in Highly Myopic Eyes</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>57</volume><issue>14</issue><spage>5856</spage><pages>5856-</pages><issn>1552-5783</issn><eissn>1552-5783</eissn><abstract>To evaluate the glaucoma-diagnostic ability of the ganglion cell-inner plexiform layer (GCIPL) thickness difference across the temporal raphe in highly myopic eyes.
We consecutively enrolled a total of 195 highly myopic eyes (axial length [AL] >26.5 mm) of 195 subjects: 93 glaucoma patients along with and 102 nonglaucomatous subjects. Cirrus high-definition optical coherence tomography (OCT) was employed to scan all of the subjects' macular and optic discs. Using a MATLAB-based customized program (the GCIPL hemifield test), a positive test result was automatically declared if the following two conditions were met: (1) the horizontal line is detected for longer than one-half of the distance from the temporal inner elliptical annulus to the outer elliptical annulus, and (2) the average GCIPL thickness difference within 10 pixels of the reference line, both above and below, is 5 μm or more. The glaucoma-diagnostic ability was computed using the area under the receiver operating characteristic curve (AUC).
Among the glaucomatous eyes, GCIPL hemifield test positivity was shown in 92.5% (86 of 93), significantly higher than that for the nonglaucomatous eyes (4.90%, 5 of 102; P <0.001). The value of AUC for the GCIPL hemifield test was excellent (0.938; sensitivity 92.50%, specificity 95.10%) and was the best compared with those for any of OCT parameters.
In highly myopic eyes, determination of the presence or absence of GCIPL thickness difference across the temporal raphe via OCT macula scan can be a useful means of distinguishing the glaucomatous damage.</abstract><cop>United States</cop><pmid>27802515</pmid><doi>10.1167/iovs.16-20116</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-5783 |
| ispartof | Investigative ophthalmology & visual science, 2016-11, Vol.57 (14), p.5856 |
| issn | 1552-5783 1552-5783 |
| language | eng |
| recordid | cdi_crossref_primary_10_1167_iovs_16_20116 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Aged Area Under Curve Case-Control Studies Female Glaucoma - diagnosis Glaucoma - physiopathology Humans Male Middle Aged Myopia, Degenerative - pathology Nerve Fibers Optic Disk - pathology Optic Nerve Diseases - pathology Retinal Ganglion Cells - pathology Tomography, Optical Coherence - methods Visual Fields - physiology |
| title | Glaucoma-Diagnostic Ability of Ganglion Cell-Inner Plexiform Layer Thickness Difference Across Temporal Raphe in Highly Myopic Eyes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T00%3A18%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glaucoma-Diagnostic%20Ability%20of%20Ganglion%20Cell-Inner%20Plexiform%20Layer%20Thickness%20Difference%20Across%20Temporal%20Raphe%20in%20Highly%20Myopic%20Eyes&rft.jtitle=Investigative%20ophthalmology%20&%20visual%20science&rft.au=Kim,%20Young%20Kook&rft.date=2016-11-01&rft.volume=57&rft.issue=14&rft.spage=5856&rft.pages=5856-&rft.issn=1552-5783&rft.eissn=1552-5783&rft_id=info:doi/10.1167/iovs.16-20116&rft_dat=%3Cpubmed_cross%3E27802515%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/27802515&rfr_iscdi=true |