Selective photoreceptor degeneration by intravitreal injection of N-methyl-N-nitrosourea

To characterize the effects of intravitreal injections of N-methyl-N-nitrosourea (MNU) in comparison to its systemic application as a measure of inducing unilateral photoreceptor degeneration. Eight-week-old male C57BL/6J mice received either intraperitoneal injections (three animals) or intravitrea...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2014-03, Vol.55 (3), p.1711
Hauptverfasser:	Rösch, Sarah, Johnen, Sandra, Mataruga, Anja, Müller, Frank, Pfarrer, Christiane, Walter, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Disease Progression Electroretinography Follow-Up Studies Immunohistochemistry Intravitreal Injections Male Methylnitrosourea - administration & dosage Methylnitrosourea - toxicity Mice Mice, Inbred C57BL Photoreceptor Cells, Vertebrate - drug effects Photoreceptor Cells, Vertebrate - pathology Retinal Degeneration - chemically induced Retinal Degeneration - pathology Retinal Degeneration - physiopathology Tomography, Optical Coherence
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