Inhibition of TGFBIp expression by lithium: implications for TGFBI-linked corneal dystrophy therapy

PURPOSE. The purpose of this study was to investigate the effects and molecular mechanisms of lithium on inhibition of TGFBIp expression as a potential therapy for TGFBI-linked corneal dystrophy. METHODS. Primary culture corneal fibroblasts were isolated from the corneas of healthy subjects and pati...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2011-05, Vol.52 (6), p.3293
Hauptverfasser:	Choi, Seung-Il, Kim, Bong-Yoon, Dadakhujaev, Shorafidinkhuja, Jester, James V, Ryu, Hyunmi, Kim, Tae-Im, Kim, Eung Kweon
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy - drug effects Blotting, Western Cells, Cultured Cornea - cytology Corneal Dystrophies, Hereditary - drug therapy Corneal Dystrophies, Hereditary - pathology Dose-Response Relationship, Drug Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression Regulation - drug effects Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans Lithium Chloride - pharmacology Phosphorylation Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Smad3 Protein - metabolism Time Factors Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism
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