Toxicity Assessment of Intravitreal Triamcinolone and Bevacizumab in a Retinal Explant Mouse Model Using Two-Photon Microscopy

Intravitreal drug administration leads to high intraocular concentrations with potentially toxic effects on ocular tissues. This study was an assessment of the toxicity of triamcinolone and bevacizumab in living retinal explants using two-photon (2P) microscopy. Wild-type mice received intravitreal...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2009-12, Vol.50 (12), p.5880-5887
Hauptverfasser:	Schlichtenbrede, Frank C, Mittmann, Wolfgang, Rensch, Florian, vom Hagen, Franziska, Jonas, Jost B, Euler, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - toxicity Animals Antibodies, Monoclonal - toxicity Antibodies, Monoclonal, Humanized Apoptosis Bevacizumab Biological and medical sciences Cell Count Coloring Agents Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - metabolism Glucocorticoids - toxicity In Situ Nick-End Labeling Injections Medical sciences Mice Mice, Inbred C57BL Microscopy, Fluorescence, Multiphoton - methods Models, Animal N-Methylaspartate - toxicity Ophthalmology Pilot Projects Retina - drug effects Retina - metabolism Retina - pathology Rhodamines Triamcinolone Acetonide - toxicity Vertebrates: nervous system and sense organs Vitreous Body
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