Repetitive Nonlethal Oxidant Injury to Retinal Pigment Epithelium Decreased Extracellular Matrix Turnover In Vitro and Induced Sub-RPE Deposits In Vivo

To determine the impact of repetitive nonlethal oxidant injury with hydroquinone (HQ) on regulation of cell membrane blebbing and molecules, which are essential in extracellular matrix turnover (ECM) maintenance, especially matrix metalloproteinase (MMP)-2, tissue inhibitor of MMP (TIMP)-2, and type...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2006-09, Vol.47 (9), p.4098-4112
Hauptverfasser:	Marin-Castano, Maria E, Striker, Gary E, Alcazar, Oscar, Catanuto, Paola, Espinosa-Heidmann, Diego G, Cousins, Scott W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Bromodeoxyuridine - metabolism Cell Count Cell Culture Techniques Cell Proliferation - drug effects Choroid - drug effects Choroid - ultrastructure Collagen Type IV - genetics Collagen Type IV - metabolism Diet Enzyme-Linked Immunosorbent Assay Extracellular Matrix - drug effects Extracellular Matrix - metabolism Extracellular Matrix - ultrastructure Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins - metabolism Humans Hydroquinones - toxicity Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Mice Mice, Inbred C57BL Mutagens - toxicity Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - ultrastructure Retina - drug effects Retina - ultrastructure Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Tissue Inhibitor of Metalloproteinase-2 - metabolism Vertebrates: nervous system and sense organs
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