Suppression by an h Current of Spontaneous Na+ Action Potentials in Human Cone and Rod Photoreceptors

The sense of vision in humans is robust, and visual flickering is rarely experienced. To investigate this mechanism, electrophysiological and molecular biological techniques were used on human cone and rod photoreceptors. Voltage-gated currents were recorded using the patch-clamp technique on isolat...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2005-01, Vol.46 (1), p.390-397
Hauptverfasser:	Kawai, Fusao, Horiguchi, Masayuki, Ichinose, Hiroshi, Ohkuma, Mahito, Isobe, Ryoko, Miyachi, Ei-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Adult Aged Biological and medical sciences Cesium - pharmacology Cyclic Nucleotide-Gated Cation Channels Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Gene Expression Humans Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Ion Channels - genetics Ion Channels - metabolism Middle Aged Patch-Clamp Techniques Potassium Channels Pyrimidines - pharmacology Retinal Cone Photoreceptor Cells - drug effects Retinal Cone Photoreceptor Cells - physiology Retinal Rod Photoreceptor Cells - drug effects Retinal Rod Photoreceptor Cells - physiology Reverse Transcriptase Polymerase Chain Reaction Sodium - metabolism Sodium Channels - genetics Sodium Channels - metabolism Tetrodotoxin - pharmacology Vertebrates: nervous system and sense organs
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