Coordinated Changes in Classes of Ribosomal Protein Gene Expression Is Associated with Light-Induced Retinal Degeneration

To identify genes with altered expression levels in the degenerating retina in a light-induced retinal degeneration (LIRD) model. Adult Sprague-Dawley rats were exposed to intense green light for 4 hours. After this treatment, the retinas were excised, RNA was extracted, and a cDNA library was prepa...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2004-11, Vol.45 (11), p.3885-3895
Hauptverfasser:	Grewal, Ruby, Stepczynski, Jadwiga, Kelln, Rhonda, Erickson, Timothy, Darrow, Ruth, Barsalou, Linda, Patterson, Michelle, Organisciak, Daniel T, Wong, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Northern Eye Proteins - genetics Eye Proteins - metabolism Gene Expression Gene Library Light Male Medical sciences Ophthalmology Oxidative Stress Polymerase Chain Reaction Radiation Injuries, Experimental - genetics Radiation Injuries, Experimental - metabolism Rats Rats, Sprague-Dawley Retina - metabolism Retina - radiation effects Retinal Degeneration - genetics Retinal Degeneration - metabolism Retinopathies Ribosomal Proteins - genetics Ribosomal Proteins - metabolism RNA - isolation & purification RNA, Ribosomal, 18S - metabolism Transcription Factors - genetics
Online-Zugang:	Volltext
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