Focal Adhesion Kinase Overexpression Induces Enhanced Pathological Retinal Angiogenesis

Focal adhesion kinase (FAK) is involved in processes integral to angiogenesis, such as cell growth, survival, and migration. FAK is activated by angiogenic growth factors, such as insulin-like growth factor (IGF)-I, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF)...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2004-12, Vol.45 (12), p.4463-4469
Hauptverfasser:	Kornberg, Lori J, Shaw, Lynn C, Spoerri, Polyxenie E, Caballero, Sergio, Grant, Maria B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Chemotaxis - drug effects Endothelial Cells - drug effects Focal Adhesion Kinase 1 Focal Adhesion Protein-Tyrosine Kinases Humans Immunohistochemistry Medical sciences Mice Mice, Inbred C57BL Ophthalmology Protein-Tyrosine Kinases - metabolism Protein-Tyrosine Kinases - pharmacology Retinal Neovascularization - chemically induced Retinal Neovascularization - etiology Retinopathies Transfection
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