Conjunctival Proinflammatory and Proapoptotic Effects of Latanoprost and Preserved and Unpreserved Timolol: An Ex Vivo and In Vitro Study

To compare the toxicity of latanoprost and preserved and unpreserved timolol on conjunctival cells. Expression of inflammatory markers and MUC5AC-related mucin production were evaluated by impression cytology in a case-control ex vivo study. The proapoptotic effect of the same drugs was also evaluat...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2004-05, Vol.45 (5), p.1360-1368
Hauptverfasser:	Pisella, Pierre-Jean, Debbasch, Caroline, Hamard, Pascale, Creuzot-Garcher, Catherine, Rat, Patrice, Brignole, Francoise, Baudouin, Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antihypertensive Agents - pharmacology Apoptosis - drug effects Benzalkonium Compounds - pharmacology Biological and medical sciences Case-Control Studies Cell Line Cell Survival Conjunctiva - drug effects Conjunctiva - metabolism Conjunctiva - pathology Eye Female Flow Cytometry Glaucoma, Open-Angle - drug therapy Glaucoma, Open-Angle - metabolism Glaucoma, Open-Angle - pathology HLA-DR Antigens - metabolism Humans Intercellular Adhesion Molecule-1 - metabolism Latanoprost Male Medical sciences Middle Aged Mucin 5AC Mucins - metabolism Pharmacology. Drug treatments Preservatives, Pharmaceutical - pharmacology Prostaglandins F, Synthetic - pharmacology Timolol - pharmacology
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