Effect of Benzalkonium Chloride on Transscleral Drug Delivery

To investigate the effect and safety of benzalkonium chloride on transscleral drug delivery in the rabbit after continuous intrascleral administration. Betamethasone 21-phosphate (BP) aqueous solutions, with or without benzalkonium chloride (BAK), were continuously administered to albino rabbit scle...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2005-02, Vol.46 (2), p.703-708
Hauptverfasser:	Okabe, Komei, Kimura, Hideya, Okabe, Junko, Kato, Aki, Shimizu, Hideo, Ueda, Takashi, Shimada, Shouichi, Ogura, Yuichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aqueous Humor - metabolism Benzalkonium Compounds - pharmacology Betamethasone - administration & dosage Betamethasone - analogs & derivatives Betamethasone - pharmacokinetics Biological and medical sciences Choroid - metabolism Chromatography, High Pressure Liquid Delivery. Postpartum. Lactation Dextrans - metabolism Drug Delivery Systems Eye - metabolism Fluorescein-5-isothiocyanate - analogs & derivatives Fluorescein-5-isothiocyanate - metabolism Glucocorticoids - administration & dosage Glucocorticoids - pharmacokinetics Gynecology. Andrology. Obstetrics Infusion Pumps, Implantable Medical sciences Permeability Preservatives, Pharmaceutical - pharmacology Rabbits Retina - metabolism Safety Sclera - drug effects Sclera - metabolism Spectrometry, Fluorescence Vitreous Body - metabolism
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