Susceptibility to Retinal Light Damage in Transgenic Rats with Rhodopsin Mutations

To determine relative light-induced retinal damage susceptibility in transgenic rats expressing mutations in the N- or C-terminal region of rhodopsin. Heterozygous transgenic rats, including P23H sublines 2 and 3 and S334ter sublines 4 and 9, were reared in dim cyclic light or in darkness before vis...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2003-02, Vol.44 (2), p.486-492
Hauptverfasser:	Organisciak, Daniel T, Darrow, Ruth M, Barsalou, Linda, Kutty, R. Krishnan, Wiggert, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Biological and medical sciences Blotting, Northern Blotting, Western Dark Adaptation Disease Susceptibility DNA - analysis DNA Fragmentation Eye Proteins Female Heme Oxygenase (Decyclizing) - metabolism Light Male Medical sciences Mutation Ophthalmology Oxidative Stress Radiation Injuries, Experimental - etiology Radiation Injuries, Experimental - genetics Radiation Injuries, Experimental - metabolism Rats - genetics Retina - metabolism Retina - pathology Retina - radiation effects Retinal Degeneration - etiology Retinal Degeneration - genetics Retinal Degeneration - metabolism Retinol-Binding Proteins - metabolism Retinopathies Rhodopsin - genetics Rhodopsin - metabolism
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