Retinal Neuronal Death Induced by Intraocular Administration of a Nitric Oxide Donor and Its Rescue by Neurotrophic Factors in Rats

To investigate the neurotoxic outcome in the rat retina exposed to nitric oxide (NO) released from an NO donor and to evaluate the effects of neurotrophic factors on the survival of NO-damaged retinal cells. An NO releasing compound, N-ethyl-2-(1-ethyl-2-hydroxy-2-nitrosohydrazino) ethanamine (NOC 1...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2003-04, Vol.44 (4), p.1760-1766
Hauptverfasser:	Takahata, Kazue, Katsuki, Hiroshi, Kume, Toshiaki, Nakata, Daisuke, Ito, Ken, Muraoka, Shizuko, Yoneda, Fumio, Kashii, Satoshi, Honda, Yoshihito, Akaike, Akinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain-Derived Neurotrophic Factor - pharmacology Cell Count Cell Death - drug effects Cell Survival - drug effects Ciliary Neurotrophic Factor - pharmacology Dose-Response Relationship, Drug Male Medical sciences Neuroprotective Agents - pharmacology Nitric Oxide Donors - toxicity Nitroso Compounds - toxicity Ophthalmology Rats Rats, Sprague-Dawley Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - pathology Retinopathies
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