Oxygen radicals in cerebral ischemia : The 2001 Willis Lecture

The sequential univalent reduction of oxygen generates superoxide, hydrogen peroxide, and hydroxyl radical. The generation of hydroxyl radical is dependent on catalysis by ferrous iron. In addition, superoxide and nitric oxide produce peroxynitrite, which spontaneously generates hydroxyl radical ind...

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Veröffentlicht in:	Stroke (1970) 2001-11, Vol.32 (11), p.2712-2716
1. Verfasser:	KONTOS, Hermes A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Ischemia - etiology Brain Ischemia - metabolism Brain Ischemia - physiopathology Cats Cerebrovascular Circulation Glutamic Acid - pharmacology Humans Medical sciences Neurology Nitric Oxide Synthase - metabolism Reactive Oxygen Species - chemistry Reactive Oxygen Species - metabolism Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Reperfusion Injury - metabolism Reperfusion Injury - physiopathology Vascular diseases and vascular malformations of the nervous system Vasodilation - drug effects
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