Efficacy of Clopidogrel-Aspirin Therapy for Stroke Does Not Exist in C YP2C19 Loss-of-Function Allele Noncarriers With Overweight/Obesity

Background and Purpose- The role of dual-antiplatelet therapy with clopidogrel plus aspirin has been demonstrated to substantially decrease the risk of recurrent stroke among patients with minor stroke and transient ischemic attack. We aimed to determine whether the efficacy of clopidogrel-aspirin t...

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Veröffentlicht in:	Stroke (1970) 2020-01, Vol.51 (1), p.224-231
Hauptverfasser:	Mo, Jinglin, Chen, Zimo, Xu, Jie, Wang, Anxin, Dai, Liye, Cheng, Aichun, Meng, Xia, Li, Hao, Wang, Yongjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Aspirin - administration & dosage Body Mass Index Clopidogrel - administration & dosage Cytochrome P-450 CYP2C19 - genetics Double-Blind Method Female Humans Loss of Function Mutation Male Middle Aged Obesity - drug therapy Obesity - enzymology Obesity - genetics Risk Factors Stroke - drug therapy Stroke - enzymology Stroke - genetics
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