Arginase II Contributes to the Ca 2+ /CaMKII/eNOS Axis by Regulating Ca 2+ Concentration Between the Cytosol and Mitochondria in a p32-Dependent Manner

Background Arginase II activity contributes to reciprocal regulation of endothelial nitric oxide synthase ( eNOS ). We tested the hypotheses that arginase II activity participates in the regulation of Ca /Ca /calmodulin-dependent kinase II / eNOS activation, and this process is dependent on mitochon...

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Veröffentlicht in:	Journal of the American Heart Association 2018-09, Vol.7 (18), p.e009579
Hauptverfasser:	Koo, Bon-Hyeock, Hwang, Hye-Mi, Yi, Bong-Gu, Lim, Hyun Kyo, Jeon, Byeong Hwa, Hoe, Kwang Lae, Kwon, Young-Guen, Won, Moo-Ho, Kim, Young Myeong, Berkowitz, Dan E, Ryoo, Sungwoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Arginase - biosynthesis Arginase - genetics Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Calcium - metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Cells, Cultured Cytosol - metabolism Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Gene Expression Regulation Humans Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria - metabolism Mitochondria - pathology Mitochondrial Proteins - metabolism Nitric Oxide Synthase Type III - metabolism Phosphorylation RNA - genetics Signal Transduction
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