Eplerenone Improves Pulmonary Vascular Remodeling and Hypertension by Inhibition of the Mineralocorticoid Receptor in Endothelial Cells

Pulmonary hypertension is characterized by progressive remodeling of the pulmonary arteries, however, this is not therapeutically targeted yet. Aldosterone and the MR (mineralocorticoid receptor) are key drivers of cardiovascular disease, and there is a growing body of evidence suggesting a role in...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2021-08, Vol.78 (2), p.456-465
Hauptverfasser:	Kowalski, Jessica, Deng, Lisa, Suennen, Chiara, Koca, Duygu, Meral, David, Bode, Christoph, Hein, Lutz, Lother, Achim
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Disease Models, Animal Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Eplerenone - pharmacology Eplerenone - therapeutic use Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - metabolism Male Mice Mice, Knockout Mineralocorticoid Receptor Antagonists - pharmacology Mineralocorticoid Receptor Antagonists - therapeutic use Receptors, Mineralocorticoid - genetics Receptors, Mineralocorticoid - metabolism Treatment Outcome Vascular Remodeling - drug effects
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