Sildenafil During Pregnancy: A Preclinical Meta-Analysis on Fetal Growth and Maternal Blood Pressure

Sildenafil is a new approach to treat fetal growth restriction (FGR) and preeclampsia. We performed a systematic meta-analysis to evaluate effects of sildenafil. Our search identified 22 animal studies (mouse, rat, rabbit, sheep, and guinea pigs) and 2 human randomized controlled trials. Data were p...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2017-11, Vol.70 (5), p.998-1006
Hauptverfasser:	Paauw, Nina D, Terstappen, Fieke, Ganzevoort, Wessel, Joles, Jaap A, Gremmels, Hendrik, Lely, A Titia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Experimentation Animals Dose-Response Relationship, Drug Female Fetal Growth Retardation - drug therapy Humans Pre-Eclampsia - drug therapy Pregnancy Randomized Controlled Trials as Topic Sildenafil Citrate - pharmacology Vasodilator Agents - pharmacology
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