Connective Tissue Growth Factor Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in Pressure Overload-Induced Heart Failure

Connective tissue growth factor (CTGF) is involved in the pathogenesis of various fibrotic disorders. However, its role in the heart is not clear. To investigate the role of CTGF in regulating the development of cardiac fibrosis and heart failure, we subjected mice to thoracic aortic constriction (T...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-06, Vol.63 (6), p.1235-1240
Hauptverfasser:	SZABO, Zoltán, MAGGA, Johanna, SIGNORE, Pierre, KERKELÄ, Risto, ALAKOSKI, Tarja, ULVILA, Johanna, PIUHOLA, Jarkko, VAINIO, Laura, KIVIRIKKO, Kari I, VUOLTEENAHO, Olli, RUSKOAHO, Heikki, LIPSON, Kenneth E
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Collagen Type I - genetics Connective Tissue Growth Factor - antagonists & inhibitors Connective Tissue Growth Factor - genetics Connective Tissue Growth Factor - immunology Constriction, Pathologic - physiopathology Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression - drug effects Heart Heart - drug effects Heart - physiopathology Heart Failure - complications Heart Failure - physiopathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Male Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Medical sciences Mice Mice, Inbred C57BL Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Plasminogen Activator Inhibitor 1 - genetics Pressure Reverse Transcriptase Polymerase Chain Reaction Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - prevention & control Ventricular Remodeling - drug effects Weight-Bearing - physiology
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