Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment–Elevation Myocardial Infarction: Results of REAL-TIMI 63B

High-density lipoprotein plays a key role in reverse cholesterol transport. In addition, high-density lipoprotein particles may be cardioprotective and reduce infarct size in the setting of myocardial injury. Lecithin-cholesterol acyltransferase is a rate-limiting enzyme in reverse cholesterol trans...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2022-09, Vol.146 (12), p.907-916
Hauptverfasser:	Bonaca, Marc P., Morrow, David A., Bergmark, Brian A., Berg, David D., Lima, Joao A.C., Hoffmann, Udo, Kato, Yoko, Lu, Michael T., Kuder, Julia, Murphy, Sabina A., Spinar, Jindrich, Oude Ophuis, Ton, Kiss, Róbert G., Lopez-Sendon, Jose, Averkov, Oleg, Wheatcroft, Stephen B., Kubica, Jacek, Carlos Nicolau, Jose, Furtado, Remo H.M., Abuhatzira, Liron, Hirshberg, Boaz, Omar, Sami A., Vavere, Andrea L., Chang, Yi-Ting, George, Richard T., Sabatine, Marc S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anterior Wall Myocardial Infarction Cholesterol Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Lecithins - therapeutic use Lipoproteins, HDL - therapeutic use Male Middle Aged Phosphatidylcholine-Sterol O-Acyltransferase - therapeutic use ST Elevation Myocardial Infarction - diagnostic imaging ST Elevation Myocardial Infarction - drug therapy Sterol O-Acyltransferase - therapeutic use Treatment Outcome
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