Preservation of Acyl Coenzyme A Attenuates Pathological and Metabolic Cardiac Remodeling Through Selective Lipid Trafficking

BACKGROUND:Metabolic remodeling in heart failure contributes to dysfunctional lipid trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty acid (LCFA) uptake and activation with coenzyme A (CoA), mediating the fate of LCFA. The authors tested whether cardiac...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2019-06, Vol.139 (24), p.2765-2777
Hauptverfasser:	Goldenberg, Joseph R, Carley, Andrew N, Ji, Ruiping, Zhang, Xiaokan, Fasano, Matt, Schulze, P Christian, Lewandowski, E Douglas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - metabolism Aged AMP-Activated Protein Kinases - metabolism Animals Biological Transport Ceramides - metabolism Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism Disease Models, Animal Energy Metabolism Fatty Acids - metabolism Female Heart Failure - genetics Heart Failure - metabolism Heart Failure - pathology Heart Failure - physiopathology Humans Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - metabolism Hypertrophy, Left Ventricular - pathology Hypertrophy, Left Ventricular - physiopathology Lipid Metabolism Male Mice, Transgenic Middle Aged Myocardium - metabolism Myocardium - pathology Oxidation-Reduction Triglycerides - metabolism Ventricular Dysfunction, Left - genetics Ventricular Dysfunction, Left - metabolism Ventricular Dysfunction, Left - pathology Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left Ventricular Remodeling
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