Inhibition of S-Adenosylhomocysteine Hydrolase Induces Endothelial Dysfunction via Epigenetic Regulation of p66shc-Mediated Oxidative Stress Pathway

BACKGROUND:Elevated levels of S-adenosylhomocysteine (SAH), the precursor of homocysteine, are positively associated with the risk of cardiovascular disease and with the development and progression of atherosclerosis. However, the role of SAH in endothelial dysfunction is unclear. METHODS:Apolipopro...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2019-05, Vol.139 (19), p.2260-2277
Hauptverfasser:	Xiao, Yunjun, Xia, Junjie, Cheng, Jinquan, Huang, Haiyan, Zhou, Yani, Yang, Xifei, Su, Xuefen, Ke, Yuebin, Ling, Wenhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - administration & dosage Adenosine - analogs & derivatives Adenosine - pharmacology Adenosylhomocysteinase - antagonists & inhibitors Adenosylhomocysteinase - genetics Adenosylhomocysteinase - metabolism Aged Animals Atherosclerosis - metabolism Coronary Artery Disease - metabolism Disease Models, Animal DNA Methylation Endothelium, Vascular - physiology Epigenesis, Genetic Female Humans Male Mice Mice, Inbred C57BL Mice, Knockout, ApoE Middle Aged Oxidative Stress RNA, Small Interfering - genetics S-Adenosylhomocysteine - blood Signal Transduction Src Homology 2 Domain-Containing, Transforming Protein 1 - genetics Src Homology 2 Domain-Containing, Transforming Protein 1 - metabolism
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