LMO7 Is a Negative Feedback Regulator of Transforming Growth Factor β Signaling and Fibrosis

BACKGROUND:Vascular smooth muscle cells (SMCs) synthesize extracellular matrix (ECM) that contributes to tissue remodeling after revascularization interventions. The cytokine transforming growth factor β (TGF-β) is induced on tissue injury and regulates tissue remodeling and wound healing, but dysre...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2019-01, Vol.139 (5), p.679-693
Hauptverfasser:	Xie, Yi, Ostriker, Allison C, Jin, Yu, Hu, Haidi, Sizer, Ashley J, Peng, Gang, Morris, Aaron H, Ryu, Changwan, Herzog, Erica L, Kyriakides, Themis, Zhao, Hongyu, Dardik, Alan, Yu, Jun, Hwa, John, Martin, Kathleen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Cells, Cultured Disease Models, Animal Extracellular Matrix - metabolism Extracellular Matrix - pathology Feedback, Physiological Fibrosis Hyperplasia Integrin alphaVbeta3 - metabolism LIM Domain Proteins - deficiency LIM Domain Proteins - genetics LIM Domain Proteins - metabolism Male Mice, Inbred C57BL Mice, Knockout Muscle, Smooth, Vascular - injuries Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Neointima Signal Transduction Transcription Factor AP-1 - metabolism Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Vascular Remodeling Vascular System Injuries - genetics Vascular System Injuries - metabolism Vascular System Injuries - pathology
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