Metabolite Profiling and Cardiovascular Event Risk: A Prospective Study of 3 Population-Based Cohorts

BACKGROUND—High-throughput profiling of circulating metabolites may improve cardiovascular risk prediction over established risk factors. METHODS AND RESULTS—We applied quantitative nuclear magnetic resonance metabolomics to identify the biomarkers for incident cardiovascular disease during long-ter...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2015-03, Vol.131 (9), p.774-785
Hauptverfasser:	Würtz, Peter, Havulinna, Aki S, Soininen, Pasi, Tynkkynen, Tuulia, Prieto-Merino, David, Tillin, Therese, Ghorbani, Anahita, Artati, Anna, Wang, Qin, Tiainen, Mika, Kangas, Antti J, Kettunen, Johannes, Kaikkonen, Jari, Mikkilä, Vera, Jula, Antti, Kähönen, Mika, Lehtimäki, Terho, Lawlor, Debbie A, Gaunt, Tom R, Hughes, Alun D, Sattar, Naveed, Illig, Thomas, Adamski, Jerzy, Wang, Thomas J, Perola, Markus, Ripatti, Samuli, Vasan, Ramachandran S, Raitakari, Olli T, Gerszten, Robert E, Casas, Juan-Pablo, Chaturvedi, Nish, Ala-Korpela, Mika, Salomaa, Veikko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Distribution Aged Biomarkers - blood Blood Pressure Cardiovascular Agents - therapeutic use Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Child Comorbidity Diabetes Mellitus - blood Diabetes Mellitus - epidemiology Docosahexaenoic Acids - blood Endophenotypes - blood Fatty Acids, Monounsaturated - blood Fatty Acids, Omega-6 - blood Female Finland - epidemiology Health Surveys High-Throughput Screening Assays - methods Humans Male Mass Spectrometry Metabolomics - methods Middle Aged Nuclear Magnetic Resonance, Biomolecular Phenylalanine - blood Prospective Studies Risk Assessment Risk Factors Sex Distribution Smoking - blood Smoking - epidemiology United Kingdom - epidemiology United States - epidemiology Young Adult
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